Current Trends in the Pharmacotherapy of Cataracts

Heruye, Segewkal; Nkenyi, Leonce N.Maffofou; Singh, Neetu; Yalzadeh, Dariush; Ngele, Kalu K.; Njie‐Mbye, Ya Fatou; Ohia, Sunny E.; Opere, Catherine A.

doi:10.3390/ph13010015

Cited by 46 publications

(32 citation statements)

References 227 publications

(305 reference statements)

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“…An alternative approach is the use of ex vivo animal lenses for cataract induction in vitro. According to a recent review about the pharmacotherapy of cataracts, the most widely used candidate substances to induce lens opacification in ex vivo lenses are Na 2 SeO 3 , hydrogen peroxide (H 2 O 2 ), and glucose 9 . Other models of cataract formation successfully used in cataract wet labs include injection of formaldehyde into lenses, microwave heating of the eye globes, or bathing of lenses in hypertonic sodium chloride (NaCl) solution 10 – 16 .…”

Section: Introductionmentioning

confidence: 99%

Comparison of methods to experimentally induce opacification and elasticity change in ex vivo porcine lenses

Ruiß

Kronschläger

Schlatter

et al. 2021

Sci Rep

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At the moment, cataract, which is the opacification of the eye’s lens, can only be treated by surgery. In order to develop and test new pharmacological treatment strategies for the disease, there is a need for an appropriate in vitro model using ex vivo animal lenses. In this study, porcine lenses were incubated in either culture medium, glucose, triamcinolone acetonide, sodium chloride, hydrogen peroxide, sodium selenite, neutral buffered formalin, or were exposed to microwave heating to experimentally induce lens opacification. Changes in the lens morphology, weight, size, and elasticity were monitored 7 days after treatment. The fastest induction of dense opacification was seen in lenses exposed to sodium chloride, neutral buffered formalin, and microwave heating. No change in the size and weight of the lenses were detected, whereas loss in elasticity could be detected in lenses treated with formalin solution or microwave heating. Thus, neutral buffered formalin- and microwave-treated ex vivo porcine lenses seem to be a suitable model for mature cataracts, whereas hypertonic sodium chloride may be useful for studies on osmolarity-induced lens opacification.

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Section: Introductionmentioning

confidence: 99%

Comparison of methods to experimentally induce opacification and elasticity change in ex vivo porcine lenses

Ruiß

Kronschläger

Schlatter

et al. 2021

Sci Rep

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“…Plant extracts were more effective in preventing cataractogenesis than anthocyanidins, flavon-3ol, flavanone, total flavone, or total flavonol [ 34 ]. The majority of the anticataract compounds tested, including plant extracts and naturally occurring compounds, lies in their antioxidant and/or free radical scavenging and/or anti-inflammatory propensity [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

Effects of Binahong (Anredera cordifolia (Tenore) Steenis) Extracts on the Levels of Malondialdehyde (MDA) in Cataract Goat Lenses

Feriyani

Maulanza

Lubis

et al. 2021

The Scientific World Journal

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Cataracts are one of the most causes of blindness in the world. Oxidative stress can form pathological conditions such as cataracts. This oxidative stress ability can be measured by the malondialdehyde (MDA) biomarker. Binahong leaves (Anredera cordifolia (Tenore) Steenis) are native plants from Indonesia that are used to treat various diseases including cataract treatment. Binahong leaf (Anredera cordifolia (Tenore) Steenis) has a high amount of flavonoids and is rich in antioxidants that can be used to treat cataracts. Objective. The purpose of this study was to assess the effect of binahong leaf extract on the levels of MDA in a goat lens with cataract-induced material. Method. As many as possible, 40 goat eye lenses were divided into several groups, namely, group I normal lenses as controls (glucose 5.5 mM), group II lenses were cataract induced with glucose concentration of 55 mM, group III lenses with glucose 55 mM + binahong leaf extract (100 μg/ml), group IV lens with glucose 55 mM + binahong leaf extract (200 μg/ml), and group V lens with glucose 55 mM + quercetin (positive control). Biochemical parameters measured in the lens homogenate are malondialdehyde lens morphology in all groups’ observations and comparisons made. Results. The results of the study found that the lens group with the addition of binahong extract showed more results transparency compared to lens groups induced by glucose concentrations of 55 mM). This shows that the diabetic cataract group experienced high oxidative stress due to the accumulation of sorbitol compounds derived from glucose which caused turbidity in the goat eye lens and increased levels of lens MDA. Binahong levels at concentrations of 100 or 200 can inhibit MDA production. Conclusion. Binahong (Anredera cordifolia (Tenore) Steenis) extract has the ability to inhibit the production of MDA levels. In glucose-induced goat lenses, binahong extract and quercetin show antioxidant and anticataract properties.

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“…Various molecules of plant origin have been suggested as possible methods of cataract treatment [ 55 , 56 ]. For instance, the extract from the leaves of Ginkgo biloba have shown to be efficient in preventing the inducement of cataracts via its antioxidant property.…”

Section: Ocular Pathologies Related To Oxidative Stress and Inflammentioning

confidence: 99%

Ocular Delivery of Polyphenols: Meeting the Unmet Needs

2021

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Nature has become one of the main sources of exploration for researchers that search for new potential molecules to be used in therapy. Polyphenols are emerging as a class of compounds that have attracted the attention of pharmaceutical and biomedical scientists. Thanks to their structural peculiarities, polyphenolic compounds are characterized as good scavengers of free radical species. This, among other medicinal effects, permits them to interfere with different molecular pathways that are involved in the inflammatory process. Unfortunately, many compounds of this class possess low solubility in aqueous solvents and low stability. Ocular pathologies are spread worldwide. It is estimated that every individual at least once in their lifetime experiences some kind of eye disorder. Oxidative stress or inflammatory processes are the basic etiological mechanisms of many ocular pathologies. A variety of polyphenolic compounds have been proved to be efficient in suppressing some of the indicators of these pathologies in in vitro and in vivo models. Further application of polyphenolic compounds in ocular therapy lacks an adequate formulation approach. Therefore, more emphasis should be put in advanced delivery strategies that will overcome the limits of the delivery site as well as the ones related to the polyphenols in use. This review analyzes different drug delivery strategies that are employed for the formulation of polyphenolic compounds when used to treat ocular pathologies related to oxidative stress and inflammation.

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Current Trends in the Pharmacotherapy of Cataracts

Cited by 46 publications

References 227 publications

Comparison of methods to experimentally induce opacification and elasticity change in ex vivo porcine lenses

Comparison of methods to experimentally induce opacification and elasticity change in ex vivo porcine lenses

Effects of Binahong (Anredera cordifolia (Tenore) Steenis) Extracts on the Levels of Malondialdehyde (MDA) in Cataract Goat Lenses

Ocular Delivery of Polyphenols: Meeting the Unmet Needs

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