Current Understanding of Circulating Tumor Cells – Potential Value in Malignancies of the Central Nervous System

Adamczyk, Łukasz; Williams, Hannah R; Frankow, Aleksandra; Ellis, Hayley Patricia; Haynes, Harry R; Perks, Claire M; Holly, Jeffrey M P; Kurian, Kathreena M.

doi:10.3389/fneur.2015.00174

Cited by 26 publications

(28 citation statements)

References 89 publications

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“…Liquid biopsies are currently used for prognostic/predictive purposes in several tumors. In GBM, the difficulty to identify affordable biomarkers to separate circulating tumor cells from normal blood cells [61] has hindered the development of this technique. Alternatives to circulating tumor cells, to be analyzed in a liquid biopsy, include RNA sequencing of "tumor-educated platelets" [62] and genomic profiling of microvescicles [63].…”

Section: Discussionmentioning

confidence: 99%

Biomarkers in Glioblastoma multiforme. Evidences from a literature review

Montano¹

2016

J Clin Transl Res

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Section: Discussionmentioning

confidence: 99%

Biomarkers in Glioblastoma multiforme. Evidences from a literature review

Montano¹

2016

J Clin Transl Res

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Section: Forewordmentioning

confidence: 99%

“…In addition, detection of circulating tumor cells in blood of cancer patients, including glioma patients are viewed as "Liquid biopsies" that have the high clinical importance in tumor diagnosis and follow up [1].…”

Section: Forewordmentioning

confidence: 99%

“…Recent therapeutic approaches to glioma and other tumors already take into account the importance of cancer stem cells and their niches [7]. In addition, detection of circulating tumor cells in blood of cancer patients, including glioma patients are viewed as "Liquid biopsies" that have the high clinical importance in tumor diagnosis and follow up [1].Overall, the complexity of the tumor and tumor microenvironment and their multiple interactive processes could only be better understood and targeted when new analytical methods such as mathematical modeling could be applied to understand this highly complex system. This could aid in the development of new therapeutic strategies that can account for and possibly unravel some of the complex and elusive behavior of cancer.…”

mentioning

confidence: 99%

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Systems Biology of Tumor Microenvironment

Rejniak¹

2016

Advances in Experimental Medicine and Biology

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Advances in Experimental Medicine and Biology presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offers readers multiple perspectives on a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research. Advances in Experimental Medicine and Biology has been publishing exceptional works in the field for over 30 years and is indexed in Medline, Scopus, EMBASE, BIOSIS, Biological Abstracts, CSA, Biological Sciences and Living Resources (ASFA-1), and Biological Sciences. The series also provides scientists with up to date information on emerging topics and techniques.More information about this series at http://www.springer.com/series/5584 Medicine and Biology ISBN 978-3-319-42021-9 ISBN 978-3-319-42023-3 (eBook) DOI 10.1007/978-3-319-42023-3 Library of Congress Control Number: 2016955061 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paperThis Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland ForewordDespite recent advances in the development of new targeted anticancer therapies, further efforts are necessary to account for the elusive behavior of cancer cells involving tumor heterogeneity and its associated stroma of the tumor microenvironment, which are providing continuous challenges for the design of new effective anti-tumor therapies.A new approach to understanding cancer biology and designing more effective therapies is mathematical modeling. Mathematical models are highly adaptable tools to deconvolute the complex, multidimensional datasets and make them amenable to analysis from different angles. The results from such studies may be instrumental in making this step forward.There is a multitude of tumor and microenvironment-associated signaling molecules, w...

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“…The numerous techniques of CTC identification can be split into broad groups according to methods of cell enrichment and cell detection (10). The two most commonly applied principles of enrichment are antibody-mediated or physical methods followed by subsequent immunohistochemical enumeration and/or genetic analysis (11).…”

Section: Detection Of Circulating Tumor Cells (Ctcs)mentioning

confidence: 99%