Current understandings and perspectives on non-cancer health effects of benzene: A global concern

Bahadar, Haji; Mostafalou, Sara; Abdollahi, Mohammad

doi:10.1016/j.taap.2014.02.012

Cited by 220 publications

(143 citation statements)

References 112 publications

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“…Gasoline immunotoxicity may indeed be influenced by additive immunotoxins, particularly when present at a high concentration or upon prolonged exposure. This concept is supported in a study by Uzma et al [169] who observed significant decreases in Ig levels, cluster of differentiation 4 (CD4) T cells and the CD4 + /CD8 + ratio among gasoline station workers exposed to benzene, which is known for its immunotoxic effects [175][176][177], including suppression of the components and function of the immune system, such as suppression of Ig production and activities of B-and T-lymphocytes in both acute and chronic epidemiological studies [140,178,179]. Increased markers of oxidative stress (ROS and serum MDA), as well as decreased antioxidant enzymes (GSH and total superoxide dismutase (T-SOD)), have been observed in exposed individuals as compared with controls, suggesting the role of oxidative stress in the pathogenesis of the immunotoxicity.…”

Section: Dermatologic Effectsmentioning

confidence: 76%

Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

Ekpenyong

Asuquo

2017

Int J Occup Med Environ Health

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The impact of health and environmental hazards, associated with the constituents of gasoline, on occupationally exposed workers has been recorded over the past few decades. However, the scientific literature on their pathogenic potential remains incomplete, which could affect the current understanding of the associated health risks. This review provides current information based on recently improved research techniques to evaluate gasoline toxicity profiles for humans. Our current knowledge provides insight into the intricate mechanism of gasoline-induced adverse effects, including the formation of reactive metabolites via bio-activation and subsequent generation of reactive oxygen species (ROS) and oxidative stress, which are involved in multiple mechanisms that are central to the aetiology of gasoline-induced toxicity. These mechanisms include covalent binding to deoxyribonucleic acid (DNA), leading to oxidative damage, tumor-suppression gene activity, and activation of pro-oncogenes. Furthermore, it results in induction of autoimmunity and local inflammatory responses, disruption of multiple neurotransmitters and immune cell function, derangement of various enzyme activities (e.g., sodiumpotassium adenosine triphosphate (Na + /K + /ATPase) activity, cytochrome P450 (CYP450), nitric oxide synthase (NOS), antioxidant enzyme activities, etc.), conjugation of bile, and non-specific cell membrane interaction, leading to damage of the membrane lipid bilayer and proteins. Available data suggests that exposure to gasoline or gasoline constituents have the potential to cause different types of illnesses. The data highlights the need to maintain safety measures via suitable research, medical surveillance, regulatory control, life style modification, early detection, and intervention to minimize exposure and manage suspected cases. They also present novel opportunities to design and develop effective therapeutic strategies against gasoline-induced detrimental effects. Int J Occup Med Environ Health 2017;30(1):1-26

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Section: Dermatologic Effectsmentioning

confidence: 76%

Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

Ekpenyong

Asuquo

2017

Int J Occup Med Environ Health

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“…[23] The possible metabolic mechanisms for the underlying alterations in the liver enzymes as proposed by the various investigators worldwide are that following inhalation, benzene and the other hydrocarbons present in gasoline are readily absorbed from the lungs and get metabolized in the liver by CYP450 2E1 oxidative pathways which contribute to the production of free radicals and quinine metabolites such as phenol, hydroquinone, benzoquinone; 1,2,4 benzenetriol. [26] These free radicals and toxic metabolites cause lipid peroxidation and damage of hepatic cell membrane, causing the release of liver enzymes in the circulation. [26,27] As this study was limited to a small sample size, so it would be premature to generalize the results of this study to the entire population of petrol pump workers; however, it cannot be also denied that the outcomes of such occupations become apparent after a number of years.…”

Section: Discussionmentioning

confidence: 99%

“…[26] These free radicals and toxic metabolites cause lipid peroxidation and damage of hepatic cell membrane, causing the release of liver enzymes in the circulation. [26,27] As this study was limited to a small sample size, so it would be premature to generalize the results of this study to the entire population of petrol pump workers; however, it cannot be also denied that the outcomes of such occupations become apparent after a number of years. Thus, it is imperative to recognize the possible dangers early and take important measures before they result into permanent morbidities.…”

Section: Discussionmentioning

confidence: 99%

Biochemical assessment of the hepatic functions of the petrol pump workers of Jaipur city

Rahul¹,

Gupta²,

Vyas³

et al. 2017

Natl J Physiol Pharm Pharmacol

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Background: In recent years, occupational health hazards have grown as one of the major public health issues worldwide. In this context, petrol pump workers were studied who by virtue of their occupation is continuously exposed to the various chemical substances and volatile organic compounds liberated in the form of gasoline vapors in their breathing zone. Aims and Objectives: To explore the effects of gasoline vapors on some biochemical parameters (the liver enzymes) among the petrol pump filling attendants working at various petrol pumps of Jaipur city. Materials and Methods: This study was conducted with 80 subjects (40 petrol pump workers working for more than three years at various petrol pumps of Jaipur city as study group and 40 matched male adults working as peons and ward boys in the different departments of the institute were considered as the control group). Liver enzymes were assessed using fully automated analyzer (Beckman Coulter AU680) available at the Central Biochemistry Laboratory in S.M.S Hospital Jaipur. Mean±standard deviation values for each parameter were determined for both the study and control groups and compared using an unpaired t-test, and P < 0.05 was considered significant. Results: Liver enzymes: serum glutamic pyruvic transaminase and serum glutamic oxaloacetic transaminase were found significantly higher among the petrol filling attendants in comparison to the control group, except serum alkaline phosphatase which was although higher in petrol filling attendants but statistically insignificant between the two groups. Conclusions: This study observed that the petrol pump workers are at greater risk of developing biochemical alterations in the hepatic enzymes with time. However, further longitudinal studies with larger sample size and regular follow-ups are required to get better insights into the results.

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“…Desta forma, o benzeno encontra-se amplamente distribuído no ambiente e a exposição a esta substância, seja ambiental ou ocupacional, tem sido associada a sérios danos à saúde humana 2 , tais como o aumento do risco de anemia aplás-tica, síndromes mielodisplásicas e leucemia mielóide aguda. Desde 1982 é considerado como uma substância comprovadamente carcinogênica para o homem e classificado no grupo A1 pela Agência Internacional para a Pesquisa do Câncer (IARC) [3][4][5] .…”

Section: Introductionunclassified

Estratégias analíticas com cromatografia e espectrometria de massas para biomonitorização da exposição ao benzeno pela determinação do ácido S-fenilmercaptúrico urinário

Gonçalves

Borges

Carvalho

et al. 2017

Rev. bras. saúde ocup.

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Resumo Introdução: o benzeno é uma substância de reconhecida toxicidade e sua biomonitorização torna-se fundamental para a prevenção de danos à saúde humana, principalmente em situações de exposição ocupacional. Dentre os biomarcadores de exposição, o ácido S-fenilmercaptúrico é considerado o único específico, mas, devido a suas baixas concentrações na urina, é requerido o uso de técnicas analíticas sensíveis capazes de quantificar traços. Objetivo: revisar metodologias baseadas na cromatografia e na espectrometria de massas para a determinação do ácido S-fenilmercaptúrico. Método: revisão da literatura sobre a determinação do ácido S-fenilmercaptúrico urinário por técnicas de cromatografia e espectrometria de massas, nas principais bases de dados científicas, considerando o período entre 1951 e 2015. Resultados: 120 documentos serviram como base teórica para a construção desta revisão. A técnica analítica mais empregada foi o acoplamento da cromatografia a líquido com a espectrometria de massas. Contudo, os métodos diferem quanto ao preparo das amostras. Conclusão: o alto custo de aquisição e a manutenção de equipamentos são fatores limitantes para a difusão dos sistemas de cromatografia e espectrometria de massas. No entanto, sua elevada sensibilidade e seletividade faz com que essas técnicas, acopladas, possibilitem elucidar situações de exposição ocupacional e ambiental a poluentes, como o benzeno.

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Current understandings and perspectives on non-cancer health effects of benzene: A global concern

Cited by 220 publications

References 112 publications

Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

Recent advances in occupational and environmental health hazards of workers exposed to gasoline compounds

Biochemical assessment of the hepatic functions of the petrol pump workers of Jaipur city

Estratégias analíticas com cromatografia e espectrometria de massas para biomonitorização da exposição ao benzeno pela determinação do ácido S-fenilmercaptúrico urinário

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