Current Update on Preclinical and Clinical Studies of Resveratrol, a Naturally Occurring Phenolic Compound

Samuel, Vijaya Paul; Gupta, Gaurav; Dahiya, Rajiv; Jain, Dev Anand; Mishra, Anurag; Dua, Kamal

doi:10.1615/critreveukaryotgeneexpr.2019027836

Cited by 21 publications

(10 citation statements)

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“…against DM. 25,26 At the same time, the study of histopathology of streptozocin-stimulated renal sections showed grave degeneration of the tubules (necrosis), glomerular dilatation (moderate), thickening of the vascular wall and inflammation of the interstitium. These alterations were reduced by Apigenin-SLNPs.…”

mentioning

confidence: 93%

<p>Apigenin-Loaded Solid Lipid Nanoparticle Attenuates Diabetic Nephropathy Induced by Streptozotocin Nicotinamide Through Nrf2/HO-1/NF-kB Signalling Pathway</p>

Li¹,

Bukhari²,

Khan³

et al. 2020

IJN

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Background: Apigenin is known to have a broad-spectrum efficacy in oxidative stress and conditions due to inflammation, although weak absorption, fast metabolic rate and a fast elimination (systemic) limit the pharmacological efficacy of this drug. Hence, we propose the usage of highly bioavailable Apigenin-solid lipid nanoparticles (SLNPs) to recognize such limitations. The defensive function of Apigenin-SLNPs on renal damage induced by streptozotocin (STZ) in animals was studied. Materials and Methods: We initially injected the rats with 35 mg kg −1 streptozocin intraperitoneally, and after 7 days, the rats were then injected 150 mg kg −1 of metformin intragastrically followed by a once-daily intragastric dose of Apigenin-SLNP (25 or 50 mg kg −1) for a continuous period of 30 days. We then measured the level of insulin and blood glucose, superoxide dismutase, catalase and malondialdehyde in the tissues of the kidney. We also observed messenger-RNA expression of Interleukin-1β, Interleukin-6 and Tumor Necrosis Factor-alpha in renal tissue through RT-PCR technique. Moreover, H&E staining and Western blotting observed the histopathological variations and protein expression of nuclear factor erythroid 2-related factor 2/heme oxygenase/Nuclear Factor-κB signaling pathway, respectively. Results: An enhancement in the expressing of nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 and a suppression in the expression of Nuclear Factor-κB occurred due to Apigenin-SLNPs treatment, which was a result of the protective mechanism of Apigenin-SLNPs which is because of not only its anti-inflammatory function (by inhibition of release of inflammatory factors) but also their anti-oxidant activity (through reduction of lipid peroxidation production). Conclusion: We found that a protective effect on diabetic nephropathy was shown due to Apigenin-SLNPs, in rats induced with streptozocin maybe through the pathway of nuclear factor erythroid 2-related factor 2/heme oxygenase-1/Nuclear Factor-κB.

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mentioning

confidence: 93%

<p>Apigenin-Loaded Solid Lipid Nanoparticle Attenuates Diabetic Nephropathy Induced by Streptozotocin Nicotinamide Through Nrf2/HO-1/NF-kB Signalling Pathway</p>

Li¹,

Bukhari²,

Khan³

et al. 2020

IJN

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“…However, we also note that there are still debates on the use of resveratrol for therapeutic purposes. One of the issues is the low bioavailability of resveratrol [159]. Moreover, there is another issue related to ammonia-induced cell swelling under certain concentrations, as described above [118].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Applications of Resveratrol in Hepatic Encephalopathy through Its Regulation of the Microbiota, Brain Edema, and Inflammation

Kim

Song

2021

JCM

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Hepatic encephalopathy is a common complication in patients with liver cirrhosis and portosystemic shunting. Patients with hepatic encephalopathy present a variety of clinical features, including neuropsychiatric manifestations, cognitive dysfunction, impaired gut barrier function, hyperammonemia, and chronic neuroinflammation. These pathogeneses have been linked to various factors, including ammonia-induced oxidative stress, neuronal cell death, alterations in the gut microbiome, astrocyte swelling, and blood-brain barrier disruptions. Many researchers have focused on identifying novel therapeutics and prebiotics in the hope of improving the treatment of these conditions. Resveratrol is a natural polyphenic compound and is known to exert several pharmacological effects, including antioxidant, anti-inflammatory, and neuroprotective activities. Recent studies suggest that resveratrol contributes to improving the neuropathogenic effects of liver failure. Here, we review the current evidence describing resveratrol’s effects in neuropathogenesis and its impact on the gut-liver axis relating to hepatic encephalopathy. We highlight the hypothesis that resveratrol exerts diverse effects in hepatic encephalopathy and suggest that these effects are likely mediated by changes to the gut microbiota, brain edema, and neuroinflammation.

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“…[44] Participation in both Gαi and Gαq transduction pathways via activation GPR18 indicates effector redundancy; maybe for critical cellular function(s) and/or homeostasis maintenance. [44][45][46] Abn-CBD causes hypotension in anesthetized dogs and mice following systemic administration and vasodilation in isolated rodents, rabbits, mice, human tissue. [47] Furthermore, Abn-CBD(trans-4-[3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol) through another putative cannabinoid receptor GPR18 activation mitigate myocardial dysfunction (but not diabetes-evoked cardiac hypertrophy), vagal dominance, oxidative myocardial stress, and declining heart and/or circulating NO and adiponectin thresholds in diabetic rats.…”

Section: The Cannabinoid Systemmentioning

confidence: 99%

Section: The Cannabinoid Systemmentioning

confidence: 99%

A molecular explanation of cardiovascular protection through abnormal cannabidiol: Involving the dysfunctional β‐adrenergic and ATP‐sensitive K+ channel activity in cardiovascular compromised preterm infants

Almalki

Alzahrani

El‐Daly

et al. 2021

J Biochem & Molecular Tox

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Growing cannabis efficacy, usage frequency, legal supply, and declining awareness of danger recently led to expanded United States cannabis exposure. In turn, cannabis use among elderly people over 50 has more than tripled in a decade and has contributed toward a positive association of cannabis use with pathological conditions, which include type II diabetes, metabolic syndrome, neurovascular and cardiovascular disease. Remarkably, all these outcome results are mediated by the involvement of the ATP-sensitive K+ channel. Cardiovascular compromise is a common syndrome in preterm infants that leads to incidence and death and has been distinguished by poor systemic flow or hypotension. Conditions of cardiovascular compromise include vasodysregulation and myocardial malfunction through dysfunctional β-adrenergic activity. To avoid organ hypoperfusion progressing to tissue hypoxia-ischemia, inotropic drugs are used. Many premature children, however, respond insufficiently to inotropic activity with adrenergic agonists. The clinical disturbance including myocardial dysfunction through the activation of the ATP-sensitive K+ channel is often involved and the comparative efficacy of the nonpsychotropic cannabinoid, abnormal cannabidiol (Abn-CBD) is not yet known. Therefore, our primary aim was to investigate the molecular exploration of the cannabinoid system specifically Abn-CBD in cardiovascular protection involving dysregulated KATP.

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Current Update on Preclinical and Clinical Studies of Resveratrol, a Naturally Occurring Phenolic Compound

Cited by 21 publications

References 0 publications

<p>Apigenin-Loaded Solid Lipid Nanoparticle Attenuates Diabetic Nephropathy Induced by Streptozotocin Nicotinamide Through Nrf2/HO-1/NF-kB Signalling Pathway</p>

<p>Apigenin-Loaded Solid Lipid Nanoparticle Attenuates Diabetic Nephropathy Induced by Streptozotocin Nicotinamide Through Nrf2/HO-1/NF-kB Signalling Pathway</p>

Therapeutic Applications of Resveratrol in Hepatic Encephalopathy through Its Regulation of the Microbiota, Brain Edema, and Inflammation

A molecular explanation of cardiovascular protection through abnormal cannabidiol: Involving the dysfunctional β‐adrenergic and ATP‐sensitive K+ channel activity in cardiovascular compromised preterm infants

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