Current Update on the Role of Inflammation in the Pathogenesis of SSc

Abstract

Systemic sclerosis (SSc), also known as scleroderma, is a systemic autoimmune rheumatic disease characterized by dysregulation of the immune system, fibrosis of the skin and visceral organs, and vasculopathy. Inflammatory activation may be important in the initiation and progression of vasculopathy and fibrosis in response to homeostatic disturbance. Numerous factors trigger and enable sustained inflammation such as increased oxidative stress, involved in progressivity and disease severity. This chapter will focus on the role of inflammation and the involvement of multiple immune mediators contributing to autoimmune activity of SSc.