Current views on neuropeptides in atopic dermatitis

Zhang, Yue; Zhang, Hanyi; Jiang, Boyue; Tong, Xiaoliang; Yan, Siyu; Lu, Jianyun

doi:10.1111/exd.14382

Cited by 14 publications

(6 citation statements)

References 127 publications

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“…Alexithymia may also be linked to altered immune responses. In susceptible individuals, neuroimmune substances, such as neuropeptides, triggered by stress, can lead to increased cutaneous inflammation, an impaired epidermal barrier, and increased itch [ 54 , 55 , 58 ]. Guilbaud et al hypothesised that alexithymia may physiologically resemble a chronic stress condition with up-regulated T helper 2 (T H 2) and impaired T helper 1 (T H 1) responses, while individuals remain emotionally unaware of their true distress [ 57 ].…”

Section: Mental Health Conditions Associated With Admentioning

confidence: 99%

The Psychology of Atopic Dermatitis

Courtney,

2024

JCM

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Atopic dermatitis (AD) is a common chronic inflammatory skin condition characterised by pruritus and recurrent eczematous patches and plaques. It impacts sleep and its visibility can lead to stigmatisation, low self-esteem, social withdrawal, reduced quality of life (QOL), and psychological burden. This study explores the relationship between AD and mental health, including possible causation pathways. A literature review was conducted in PubMed without using limiters. AD carries higher odds of suicidality and an increased risk of depression, anxiety, alexithymia, and obsessive–compulsive disorder (OCD) across all severities. While some studies report an association of AD with attention deficit hyperactivity disorder (ADHD), and possibly autism spectrum disorder (ASD), others do not. There is increasing evidence that AD contributes to chronic low-grade inflammation and cognitive impairment (CI). Causative factors for mental health complications of AD likely include both psychosocial and biological variables. AD is associated with higher levels of cutaneous and circulating proinflammatory cytokines; these can breach the blood–brain barrier and trigger central nervous system events, including oxidative stress, neurotransmitter breakdown, altered serotonin metabolism, and reduced neurogenesis in several brain regions. Excessive inflammation in AD may thus contribute to CI, depression, and suicidality. AD providers should be vigilant about mental health.

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Section: Mental Health Conditions Associated With Admentioning

confidence: 99%

The Psychology of Atopic Dermatitis

Courtney,

2024

JCM

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“…Moreover, in vivo, increased levels of TSLP work directly on CD4+ T cells to cause the establishment of IL-13-single-positive (IL-13-SP) and IL-4+IL-13+ double-positive populations in lymph nodes modifying the function of immune system [43]. Harmful stimuli and stress via, for instance, upraised levels of nerve growth factor (NGF), can uprise the amount of nerve fibres that secrete neuropeptides such as neuropeptide Y (NPY), substance P, calcitoningene regulated peptide (CGRP), or brain natriuretic peptide (BNP) [44]. These factors regulate the function of various inflammatory cells including mast cells and release of cytokines [44].…”

Section: Neurologic and Psychiatric Diseases In Admentioning

confidence: 99%

“…Harmful stimuli and stress via, for instance, upraised levels of nerve growth factor (NGF), can uprise the amount of nerve fibres that secrete neuropeptides such as neuropeptide Y (NPY), substance P, calcitoningene regulated peptide (CGRP), or brain natriuretic peptide (BNP) [44]. These factors regulate the function of various inflammatory cells including mast cells and release of cytokines [44].…”

Section: Neurologic and Psychiatric Diseases In Admentioning

confidence: 99%

Is Atopic Dermatitis Only a Skin Disease?

Mesjasz

Mazurkiewicz-Bełdzińska

Chałubiński

et al. 2023

IJMS

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Atopic dermatitis (AD) is a chronic, pruritic, inflammatory dermatosis that imposes significant patient and population burdens. In addition to the cutaneous signs and symptoms, growing evidence suggests that AD is systemic in nature. Certain diseases can possibly co-occur with AD as a result of coincidental exposure to similar environmental factors. However, it is also suspected that they are linked to the pathogenesis of AD through more complex genetic and immunological mechanisms, but these correlations remain less understood. It is of great need to seek explanations for the higher frequency of the number of cardiovascular, autoimmune, neurological, psychiatric, and metabolic disorders that have been observed in epidemiologic investigations among AD patients. Moreover, analysing the immunology of chronic inflammation and its correction, activation, or suppression may prevent the development of a variety of comorbidities. As comorbid diseases in patients diagnosed with AD may potentially go undetected, physicians should be aware of them.

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“…Importantly, activated sensory neurons, in turn, could release neuropeptides or transmitters that act on mast cells to form a neuroimmune feedback loop. It has been demonstrated that mast cells have several receptors for neuropeptides, such as substance P (SP), calcitonin-gene-related peptide (CGRP), neuropeptide Y (NPY), and vasoactive intestinal peptide (VIP), expressed on their surface [ 28 ]. Decades ago, mast cells were discovered to degranulate in response to nerve growth factor (NGF) by the TrkA tyrosine receptor [ 29 ].…”

Section: Atopic Dermatitis (Ad): a Paradigm Of Itch Neuroimmune Mecha...mentioning

confidence: 99%

Neural Regulation of Innate Immunity in Inflammatory Skin Diseases

Huang

Wang

2023

Pharmaceuticals

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As the largest barrier organ of the body, the skin is highly innervated by peripheral sensory neurons. The major function of these sensory neurons is to transmit sensations of temperature, pain, and itch to elicit protective responses. Inflammatory skin diseases are triggered by the aberrant activation of immune responses. Recently, increasing evidence has shown that the skin peripheral nervous system also acts as a regulator of immune responses, particularly innate immunity, in various skin inflammatory processes. Meanwhile, immune cells in the skin can express receptors that respond to neuropeptides/neurotransmitters, leading to crosstalk between the immune system and nervous system. Herein, we highlight recent advances of such bidirectional neuroimmune interactions in certain inflammatory skin conditions.

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Current views on neuropeptides in atopic dermatitis

Cited by 14 publications

References 127 publications

The Psychology of Atopic Dermatitis

The Psychology of Atopic Dermatitis

Is Atopic Dermatitis Only a Skin Disease?

Neural Regulation of Innate Immunity in Inflammatory Skin Diseases

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