Curvature-processing domains in primate V4

Tang, Rendong; Song, Qianling; Liu, Ying; Cai, Xingya; Lu, Haidong

doi:10.7554/elife.57502

Cited by 28 publications

(30 citation statements)

References 48 publications

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“…Our results are bolstered by another recent study which also reports the presence of curvature domains in V4 ( Tang et al, 2020 ). Using stimuli that included simple shapes (e.g.…”

Section: Discussionsupporting

confidence: 87%

“…We are excited that the combination of MRI ( Op de Beeck et al, 2008 ; Popivanov et al, 2015 ; Yue et al, 2014 ; Bao et al, 2020 ), optical imaging ( Ghose and Ts'o, 1997 ; Tanigawa et al, 2010 ; Lu et al, 2018 ; Jiang et al, 2019 ; this study; Tang et al, 2020 ), and two-photon ( Jiang et al, 2019 ; Tang et al, 2020 ) scale studies are providing a functional organizational view of shape processing in the ventral visual pathway. While there is much yet unknown about curvature and shape representation, there is enough to see a sketch of the organizational hierarchy.…”

Section: Discussionmentioning

confidence: 86%

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Curvature domains in V4 of macaque monkey

Song

Wang

et al. 2020

eLife

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An important aspect of visual object recognition is the ability to perceive object shape. Two basic components of complex shapes are straight and curved contours. A large body of evidence suggests a modular hierarchy for shape representation progressing from simple and complex orientation in early areas V1 and V2, to increasingly complex stages of curvature representation in V4, TEO, and TE. Here, we reinforce and extend the concept of modular representation. Using intrinsic signal optical imaging in Macaque area V4, we find sub-millimeter sized modules for curvature representation that are organized from low to high curvatures as well as domains with complex curvature preference. We propose a possible ‘curvature hypercolumn’ within V4. In combination with previous studies, we suggest that the key emergent functions at each stage of cortical processing are represented in systematic, modular maps.

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“…Our results are bolstered by another recent study which also reports the presence of curvature domains in V4 ( Tang et al, 2020 ). Using stimuli that included simple shapes (e.g.…”

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 86%

Curvature domains in V4 of macaque monkey

Song

Wang

et al. 2020

eLife

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“…Hu (Hu et al, 2020) used intrinsic signal optical imaging (ISOI), finding functional domains that prefer curved over straight gratings. Tang (Tang et al, 2020) used both ISOI and 2P imaging, finding functional domains that prefer circles over rectilinear triangles. In general, these two imaging studies alongside our own provide clear replication of the core importance of curvature as an organizing principle in the functional architecture of V4.…”

Section: Discussionmentioning

confidence: 99%

Clustered functional domains for curves and corners in cortical area V4

Jiang

Andolina

et al. 2021

eLife

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The ventral visual pathway is crucially involved in integrating low-level visual features into complex representations for objects and scenes. At an intermediate stage of the ventral visual pathway, V4 plays a crucial role in supporting this transformation. Many V4 neurons are selective for shape segments like curves and corners, however it remains unclear whether these neurons are organized into clustered functional domains, a structural motif common across other visual cortices. Using two-photon calcium imaging in awake macaques, we confirmed and localized cortical domains selective for curves or corners in V4. Single-cell resolution imaging confirmed that curve or corner selective neurons were spatially clustered into such domains. When tested with hexagonal-segment stimuli, we find that stimulus smoothness is the cardinal difference between curve and corner selectivity in V4. Combining cortical population responses with single neuron analysis, our results reveal that curves and corners are encoded by neurons clustered into functional domains in V4. This functionally-specific population architecture bridges the gap between the early and late cortices of the ventral pathway and may serve to facilitate complex object recognition.

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“…One to 3 injections were given to each animal (different tracers for different functional sites). An imaging chamber (Li et al 2013;Tang et al 2020) was implanted. In vivo uorescent images were examined (not shown) one week after the tracer injections to con rm tracer loading and to determine the center of the tracer diffusion.…”

Section: Visual Stimulusmentioning

confidence: 99%

“…In addition to color, orientation, and direction, it has been shown that V4 has other functional architectures, such as size (Ghose and Ts'o 1997), curvature (Hu et al 2020;Tang et al 2020), and binocular disparity (Tanabe et al 2005;Fang et al 2019). The functional inputs from V2 for these V4 functional architectures can be studied in a similar way.…”

Section: Origin Of V4 Direction Selectivitymentioning

confidence: 99%

Functional-Specific Projections from V2 to V4 in Macaque Monkeys

Chen¹,

Yan²,

Chen³

et al. 2021

Preprint

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Previous studies have revealed modular projections from area V2 to area V4 in macaques. Specifically, V2 neurons in cytochrome oxidase (CO)-rich thin and CO-sparse pale stripes project to distinct regions in V4. However, how these modular projections relate to the functional subcompartments of V4 remains unclear. In this study, we injected retrograde fluorescent tracers into different functional domains (color, orientation, and direction) in V4 that were identified with intrinsic signal optical imaging. We examined the labeled neurons in area V2 and their locations with respect to the CO patterns. Covariation was observed between the functional properties of the V4 injection sites and the numbers of labeled neurons in particular CO stripes. This covariation indicates that the color domains in V4 mainly received inputs from V2 thin stripes, whereas V4 orientation domains received inputs from pale (major) and thick (minor) stripes. Although there are motion-sensitive domains in both V2 and V4, our results did not reveal a functional-specific feedforward projection between them. These results confirmed previous findings of modular projections from V2 to V4 and provided functional specificity for these anatomical projections. Together, these findings indicate that color and form remain separate in the ventral midlevel visual processing.

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Curvature-processing domains in primate V4

Cited by 28 publications

References 48 publications

Curvature domains in V4 of macaque monkey

Curvature domains in V4 of macaque monkey

Clustered functional domains for curves and corners in cortical area V4

Functional-Specific Projections from V2 to V4 in Macaque Monkeys

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