Customized 3D printed multi-drug systems: an effective and efficient approach to polypharmacy

Mazarura, Kundai R.; Kumar, Pradeep; Choonara, Yahya E.

doi:10.1080/17425247.2022.2121816

Cited by 11 publications

(5 citation statements)

References 106 publications

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“…Such observed burst release has potential applications in conditions such as bronchial asthma, angina pectoris, and ulcers, where a rapid-release profile could offer specific benefits . Furthermore, 3D printing has been demonstrated for the personalization of multidrugs within polypills − and such a burst release matrix can be used favorably; whereby some drugs can be embedded into a 3DP layer with burst release matrix to provide immediate relief of symptoms, while another 3DP layer incorporates a drug that requires sustained therapeutic effect. Alternatively, in PLA-BSG and PLA-SCG, which exhibited a delayed burst release profile after a 2 h period, this matrix may be beneficial where drug–drug interactions should be avoided.…”

Section: Resultsmentioning

confidence: 99%

Utilizing Food Waste in 3D-Printed PLA Formulations to Achieve Sustainable and Customizable Controlled Delivery Systems

Wang,

Yong,

Loo

2024

ACS Omega

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This is the first study that explores blending polylactic acid (PLA) with various biomasses, including food wastes�brewer's spent grain (BSG), spent coffee grounds (SCG), sesame cake (SC), and thermoplastic starch (TPS) biomass to create composite gastric floating drug delivery systems (GFDDS) through 3D printing. The aim is to investigate the influence of biomass percentage, biomass type, and printing parameters on their corresponding drug release profiles. 3D-printed (3DP) composite filaments were prepared by blending biomasses and PLA before in vitro drug release studies were performed using hydrophilic and hydrophobic model drugs, metoprolol tartrate (MT), and risperidone (RIS). The data revealed that release profiles were influenced by composite compositions and wall thicknesses of 3DP GFDDS capsules. Up to 15% of food waste could be blended with PLA for all food waste types tested. Delivery studies for PLA-food wastes found that MT was fully released by 4 h, exhibiting burst release profiles after a lag time of 0.5 to 1.5 h, and RIS could achieve a sustained release profile of approximately 48 h. PLA-TPS was utilized as a comparison and demonstrated variable release profiles ranging from 8 to 120 h, depending on the TPS content. The results demonstrated the potential for adjusting drug release profiles by incorporating affordable biomasses into GFDDS. This study presents a promising direction for creating delivery systems that are sustainable, customizable, and cost-effective, utilizing sustainable materials that can also be employed for agricultural, nutraceutical, personal care, and wastewater treatment applications.

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Section: Resultsmentioning

confidence: 99%

Utilizing Food Waste in 3D-Printed PLA Formulations to Achieve Sustainable and Customizable Controlled Delivery Systems

Wang,

Yong,

Loo

2024

ACS Omega

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“…Oral drug delivery has long been a preferred method due to its safety, high compliance, and cost-effectiveness. 147 However, challenges persist due to poor gastrointestinal stability and pre-systemic metabolism, necessitating support systems for effective delivery. 148 Typically, drugs are absorbed in the small intestine, heavily perfused and a site for metabolism.…”

Section: Mof-based Carriers In Drug Delivery Systemsmentioning

confidence: 99%

Recent progress and challenges of MOF-based nanocomposites in bioimaging, biosensing and biocarriers for drug delivery

Nguyen,

et al. 2024

Nanoscale Adv.

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“…In addition to dose personalization, 3D printing offers a versatile manufacturing platform that enables tailoring of tablet shape, palatability, release kinetics, and swallowability (Fig. 3) (56)(57)(58)(59). This way, pediatric patients might better adhere to medication regimens.…”

Section: Personalization Options Of 3d Printed Medicationsmentioning

confidence: 99%

The potential of three-dimensional printing for pediatric oral solid dosage forms

Kreft,

Fanous,

Möckel

2024

Acta Pharmaceutica

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Pediatric patients often require individualized dosing of medicine due to their unique pharmacokinetic and developmental characteristics. Current methods for tailoring the dose of pediatric medications, such as tablet splitting or compounding liquid formulations, have limitations in terms of dosing accuracy and palatability. This paper explores the potential of 3D printing as a solution to address the challenges and provide tailored doses of medication for each pediatric patient. The technological overview of 3D printing is discussed, highlighting various 3D printing technologies and their suitability for pharmaceutical applications. Several individualization options with the potential to improve adherence are discussed, such as individualized dosage, custom release kinetics, tablet shape, and palatability. To integrate the preparation of 3D printed medication at the point of care, a decentralized manufacturing model is proposed. In this setup, pharmaceutical companies would routinely provide materials and instructions for 3D printing, while specialized compounding centers or hospital pharmacies perform the printing of medication. In addition, clinical opportunities of 3D printing for dose-finding trials are emphasized. On the other hand, current challenges in adequate dosing, regulatory compliance, adherence to quality standards, and maintenance of intellectual property need to be addressed for 3D printing to close the gap in personalized oral medication.

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Customized 3D printed multi-drug systems: an effective and efficient approach to polypharmacy

Cited by 11 publications

References 106 publications

Utilizing Food Waste in 3D-Printed PLA Formulations to Achieve Sustainable and Customizable Controlled Delivery Systems

Utilizing Food Waste in 3D-Printed PLA Formulations to Achieve Sustainable and Customizable Controlled Delivery Systems

Recent progress and challenges of MOF-based nanocomposites in bioimaging, biosensing and biocarriers for drug delivery

The potential of three-dimensional printing for pediatric oral solid dosage forms

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