Cutaneous and systemic adverse reactions to antibiotics

Díaz, Laura; Ciurea, Ana M.

doi:10.1111/j.1529-8019.2012.01494.x

Cited by 23 publications

(13 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In most incidents of drug-induced SJS/TEN, initial skin symptoms appear 2–3 weeks after suspicious medication application, but antibiotics can act more rapidly (a few days, even after a single dose) [5, 8]. Therefore, we suggest norfloxacin is a causative agent of SJS/TEN in the reported case.…”

Section: Discussionmentioning

confidence: 74%

“…Uncommonly, the disease is caused by Mycoplasma spp., Herpes simplex virus or Hepatitis C and B viruses infections. The highest mortality among causing drugs was found from antibiotic treatment, the lowest from using non-steroidal anti-inflammatory drugs [5]. Most widespread antibiotics causing SJS/TEN are aminopenicillins, cephalosporins, macrolides, tetracyclines and quinolones (mainly ciprofloxacin) [6, 7].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Stevens-Johnson syndrome/toxic epidermal necrolysis presumably induced by norfloxacin

Maciejewska¹,

Jankowski²,

Zegarska³

et al. 2014

pdia

View full text Add to dashboard Cite

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare mucocutaneous, unpredictable, life-threatening drug side reactions. A very rare case of norfloxacin-induced SJS/TEN overlap with uncommon clinical presentation in a patient with a suspected urinary tract infection is reported. The SJS/TEN management with possible treatment capabilities are discussed. In spite of only two previous reports of norfloxacin-induced SJS and TEN we believe that awareness of norfloxacin adverse reactions needs to be raised among prescribers.

show abstract

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Stevens-Johnson syndrome/toxic epidermal necrolysis presumably induced by norfloxacin

Maciejewska¹,

Jankowski²,

Zegarska³

et al. 2014

pdia

View full text Add to dashboard Cite

show abstract

“…Ancak bu akut faz reaktanlarının yüksekliğinin nedeni konusunda yeterli veri yoktur. Şüpheli tedavinin kesilmesiyle düzelmenin başlaması da tanıyı destekler (6)(7)(8)(9). İlaç kesildikten sonra hastalık kendini sınırlayan karakterdedir.…”

Section: İrdelemeunclassified

Acute Generalized Exanthematous Pustulosis Due to Pyrazinamide in a Patient Receiving Antituberculous Treatment: A Case Report

Harman¹,

Yıldırım²,

Günal³

et al. 2016

Klimik Dergisi

View full text Add to dashboard Cite

GirişDünya Sağlık Örgütü (DSÖ) tarafından 2005 yılında 5 milyondan fazla yeni tüberküloz (akciğer ve akciğer dışı olmak üzere tüm formlar) olgusu bildirilmiştir. Akciğer dışı tüberküloz (AD-TB) ülkemizde tüm tüberküloz hastalarının yaklaşık %30'unda görülür. En sık küçük çocuk-larda görülmekle birlikte özellikle HIV ile infekte yetişkin-lerde de ortaya çıkabilir. ABD'de tüm AD-TB olgularının %5'ini santral sinir sitemi tüberkülozu oluşturmaktadır. Tüberküloz tedavisinde kullanılan ilaçlar içinde, birinci seçenek olarak izoniazid, rifampisin, etambutol, streptomisin, pirazinamid ve ikinci seçenek olarak aminoglikozidler, polipeptidler, florokinolonlar, tiyoamidler, sikloserin ve para-aminosalisilik asid yer alır (1,2). OlguEvli, 3 çocuklu, 27 yaşında, kadın hasta 15 gündür sü-ren ateş, baş ağrısı, bulantı nedeniyle başvurdu. Hastanın sistemik muayenesinde şuuru açık, oryantasyon ve kooperasyon tamdı. Ense sertliği pozitifti. Hasta meningoensefalit ön tanısıyla yatırıldı. Bilinen bir hastalığı, sigara, alkol ve ilaç kullanımı, kendisinde ve ailesinde tüberküloz öyküsü yoktu. HBsAg, anti-HCV ve anti-HIV (ELISA) testi negatifti. Lomber ponksiyonla alınan beyin-omurilik sıvısı (BOS)'nda glukoz 15 mg/dl (eşzamanlı kan şekeri 105 mg/ dl), protein 148 mg/dl ve hücre sayısı 110/mm 3 (lenfosit) bulundu. Kontrastlı kraniyal manyetik rezonans (MR) gö-rüntülemesinde tentorium, sellar, suprasellar sistern dü-zeyinde meningeal yapılarda düzensiz kalınlaşmalar ve AbstractAcute generalized exanthematous pustulosis (AGEP) is a rare cutaneous eruption characterized by generalized non-follicular sterile pustules. The most frequent causes are antibiotics, sulphonamides, and antipyretic analgesics. It is rarely reported to occur due to antituberculous medications. We present here a 27-year-old patient in whom AGEP developed 3 times after the same treatment while receiving a combination of isoniazid, rifampin, ethambutol and pyrazinamide for tuberculous meningitis, in whom the causative drug was found to be pyrazinamide. Klimik Dergisi 2016; 29(3): 133-5.

show abstract

“…SJS and TEN are serious cutaneous eruptions characterized by extensive exfoliation and mucosal membrane involvement. Epidermal detachment is present in <10% in SJS, 10%-30% in SJS/TEN overlap, and >30% in TEN [23]. Erythroderma, target-like lesions, extensive erosions, and/or bullae in addition to sloughing of the skin and mucosal sites are common findings (Figure 4).…”

Section: Delayed-type Reactions: Types II Iii and Ivmentioning

confidence: 99%

Antibiotic Hypersensitivity Reactions and Approaches to Desensitization

Legendre¹,

Muzny

Marshall³

et al. 2013

Clinical Infectious Diseases

View full text Add to dashboard Cite

Before initiating antibiotic therapy, drug hypersensitivity is an important consideration, and a common strategy is to avoid giving patients medications when a high likelihood of severe reactions exists. With an increase in antibiotic resistance and a decrease in novel antibiotics, there is greater pressure to consider antibiotics in patients with a history of adverse reactions. The major concerns include IgE-mediated, or type I, reactions, anaphylaxis, Stevens-Johnson syndrome, and toxic epidermal necrolysis. Some antibiotics with similar characteristics, such as cephalosporins and penicillins, may be given safely to patients with a certain allergy profile. There is still greater concern when considering antibiotics for patients with reported allergy. Desensitization is a strategy to safely induce drug tolerance to a specific drug to limit the possibility of a type I reaction.

show abstract

Cutaneous and systemic adverse reactions to antibiotics

Cited by 23 publications

References 29 publications

Stevens-Johnson syndrome/toxic epidermal necrolysis presumably induced by norfloxacin

Stevens-Johnson syndrome/toxic epidermal necrolysis presumably induced by norfloxacin

Acute Generalized Exanthematous Pustulosis Due to Pyrazinamide in a Patient Receiving Antituberculous Treatment: A Case Report

Antibiotic Hypersensitivity Reactions and Approaches to Desensitization

Contact Info

Product

Resources

About