Cutaneous Benign Mixed Tumor (Chondroid Syringoma) of the Eyelid: Clinical Presentation and Management

Mandeville, John; Roh, Joo Heon; Woog, John J.; Gonnering, Russell S.; Levin, Peter S.; Mazzoli, Robert A.; Ainbinder, Darryl J.; Older, J. Justin; Moulin, Alexandre; Kiel, Ralf; Kim, Yoon-Duck; Dryja, Thaddeus P.

doi:10.1097/01.iop.0000117337.65340.e5

Cited by 37 publications

(13 citation statements)

References 24 publications

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“…Around 75% of cutaneous pleomorphic adenomas, also called chondroid syringomas, arise from the head and neck region [22]. Although the stromal component of the tumor has been postulated to be derived from the myoepithelial cells of the outer layer of the ductules, Mandeville et al [23] reported that in some patients, histological examination of the tumor revealed both eccrine and apocrine characteristics; therefore, the origin of the tumor is uncertain. In the management of such nodular lesions, differential diagnoses should include other cutaneous lesions, such as epidermal cysts, pilomatricoma, dermoid cysts, sebaceous cysts, neurofibroma, and even basal cell carcinoma [24].…”

Section: Discussionmentioning

confidence: 98%

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Extra-major salivary gland pleomorphic adenoma of the head and neck: a 10-year experience and review of the literature

Kuo

Chang

et al. 2010

Eur Arch Otorhinolaryngol

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Pleomorphic adenomas, or benign mixed tumors, make up 65% of all salivary gland tumors. They also can be found as solid tumors in other parts of the head and neck region, such as the auditory canal, the eyelids, and the orbital area. In this study, we investigated extra-major salivary gland pleomorphic adenomas of the head and neck region retrospectively at a tertiary care center. Between March 1998 and June 2009, 37 patients underwent primary surgery for extra-major salivary gland pleomorphic adenoma of the head and neck. The duration of symptoms, radiographic findings, operative procedures, and pathologic findings were documented. Of the 37 patients enrolled, 22 were male and 15 were female, with a median age of 57 years. Tumors were found in the soft palate, hard palate, nasopharynx, orbital area, trachea, buccal mucosa, cheek, nasal septum, upper lip, lower eyelid, and external auditory canal. Cellular variant of the pleomorphic adenoma was found in four patients, while the remaining patients presented with the classic variant. No myxoid subgroup was noted in our study. Carcinoma ex pleomorphic adenoma was observed only in one patient for whom radical surgery was performed. Twenty-eight patients (76%) had long-term follow-ups, with the average follow-up period being 4.5 years. Local recurrence was observed in three patients, and they underwent revision surgery during the follow-up period. Our results indicate that extra-major salivary gland pleomorphic adenomas are most commonly found in the soft palate. Wide excision was the treatment of choice, although its efficacy might be compromised with cosmetics and functional structures of the head and neck. Therefore, long-term follow-up of patients is necessary.

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Section: Discussionmentioning

confidence: 98%

“…In the management of such nodular lesions, differential diagnoses should include other cutaneous lesions, such as epidermal cysts, pilomatricoma, dermoid cysts, sebaceous cysts, neurofibroma, and even basal cell carcinoma [24]. Wide excision of tumor is considered to be the best management [23].…”

Section: Discussionmentioning

confidence: 99%

Extra-major salivary gland pleomorphic adenoma of the head and neck: a 10-year experience and review of the literature

Kuo

Chang

et al. 2010

Eur Arch Otorhinolaryngol

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“…[610] The classification of these tumors into an apocrine type or eccrine type relies on the histopathological appearance of the glandular component. Comparable to our case, the tumor may originate from the apocrine sweat glands, where the glandular epithelial component is lined by a double layer of cuboidal epithelial cells arranged in islands, chords or tubules.…”

Section: Discussionmentioning

confidence: 99%

Pleomorphic adenoma of the eyelid with apocrine gland origin; an atypical location

Rothwell

Campelos

Prazeres

2016

J Ophthalmic Vis Res

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Purpose:To describe the clinical presentation and treatment of a patient with a cutaneous pleomorphic adenoma of the eyelid.Case Report:A 73-year-old male patient presented with a nodular mass on the lateral third of his right upper eyelid, which had slowly enlarged over 10 years. Radiologic features were of an extra-conical mass, with no invasion of adjacent structures. An excisional biopsy of the lesion was performed. The histopathological examination revealed a biphasic tumor, composed of tubules with a double layer of epithelial cells arranged in a chondromyxoid stroma. The inner epithelial cells were positive for pancytokeratins AE1/AE3 and carcinoembryonic antigen. The outer epithelial cells and stromal component expressed vimentin and S100 protein. These pathologic findings were consistent with a palpebral pleomorphic adenoma, with an apocrine gland origin.Conclusion:Pleomorphic adenomas of the skin are rare tumors, and even less frequent as tumors of the ocular adnexa. These lesions should be considered in the differential diagnosis of palpebral nodular masses, and complete excision should be attempted due to the possibility of malignant transformation.

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“…This relatively uncommon tumor rarely affects the ocular adnexa. 2 To our knowledge, chondroid syringoma arising from the lower eyelid with severe ectropion is highly unusual.…”

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confidence: 95%

“…2 In 1961, Hirsch and Helwig 3 introduced the term chondroid syringoma to describe this tumor, which is characterized by the presence of sweat gland elements lying within a cartilage-like stroma. 2 This benign skin adnexal tumor usually develops as a slowly growing intradermal or subcutaneous nodule on the face. This relatively uncommon tumor rarely affects the ocular adnexa.…”

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confidence: 99%

A Rare Case of Chondroid Syringoma Arising from the Lower Eyelid with Ectropion

Ogawa

Mitsuhashi

Oki

2006

Plastic and Reconstructive Surgery

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M ixed tumor of the skin was originally described by Billroth in 1859 1 as an entity histologically similar to the mixed tumor of the salivary glands. 2 In 1961, Hirsch and Helwig 3 introduced the term chondroid syringoma to describe this tumor, which is characterized by the presence of sweat gland elements lying within a cartilage-like stroma. 2 This benign skin adnexal tumor usually develops as a slowly growing intradermal or subcutaneous nodule on the face. This relatively uncommon tumor rarely affects the ocular adnexa. 2 To our knowledge, chondroid syringoma arising from the lower eyelid with severe ectropion is highly unusual. CASE REPORTA 61-year-old woman presented a painless and slowly developing mass (over 25 years) in the left lower eyelid with severe ectropion (Fig. 1). The mass was also exposed on the surface of the palpebral conjunctiva. Visual acuity, intraocular pressure, eye position, and ocular motility were all normal bilaterally. Our original differential diagnosis was dermoid, foreign body granuloma, hordeolum, and chondroid syringoma. The mass, measuring 31 ϫ 22 ϫ 19 mm, was extirpated en bloc, and the lower eyelid and palpebral conjunctiva were sutured to correct the ectropion under general anesthesia (Fig. 2). Histopathologic analysis revealed that the epithelial component had glandular features and a myxoid stromal component (Fig. 3). No atypical cells were visible. These findings were consistent with the diagnosis of chondroid syringoma (mixed tumor of the skin). Postoperative recovery was uneventful, and the tumor has not recurred during the past 5 years (Fig. 4).

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Cutaneous Benign Mixed Tumor (Chondroid Syringoma) of the Eyelid: Clinical Presentation and Management

Cited by 37 publications

References 24 publications

Extra-major salivary gland pleomorphic adenoma of the head and neck: a 10-year experience and review of the literature

Extra-major salivary gland pleomorphic adenoma of the head and neck: a 10-year experience and review of the literature

Pleomorphic adenoma of the eyelid with apocrine gland origin; an atypical location

A Rare Case of Chondroid Syringoma Arising from the Lower Eyelid with Ectropion

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