Cutaneous Chronic Graft Versus Host Disease in a Symmetric Distribution

Abstract

Graft-versus-host disease (GVHD) is a common complication following patients who have undergone allogenic hematopoietic stem cell transplantation (allo-HSCT). While GVHD has been previously sub-categorized through a temporal relationship upon transplantation, revisions from the National Institutes of Health have modified the diagnosis criteria to be more involved with specific signs and symptoms. Chronic classifications of GVHD include non-sclerotic and sclerotic forms, and the sclerotic form can be further classified based on morphologies such as lichen-sclerosis-like, sclerodermoid or morphea-like plaques. Generalized morphea can have similar histopathological findings but in order to be diagnosed, certain diagnostic criteria must be met. Herein, we report a patient with linear and inflammatory morphea morphology of chronic GVHD, which presents symmetrically on both lower extremities.

Prominent Role of Type 2 Immunity in Skin Diseases: Beyond Atopic Dermatitis

“…Notably, it may present with scarring phenotypes such as sclerodermoid and/or morpheiform and/or lichen sclerosus-like and/or eosinophilic fasciitis features. 156 Sclerodermoid cGVHD is among the most life-threatening and hardest to treat cGVHD subtypes. 157 It is plausible that pro-fibrotic Type 2 inflammation may be important in sclerodermoid phenotype.…”

Afectación musculoesquelética y del tejido conectivo en pacientes sometidos a trasplante alogénico de progenitores hematopoyéticos con enfermedad injerto contra receptor crónica: caracterización clínica y biológica

“…Habitualmente las lesiones cutáneas escleróticas presentan una distribución simétrica (107) y con frecuencia son patrones mixtos, coexistiendo distintos tipos de lesiones esclerodermiformes en un mismo paciente (99) . .…”