Cutaneous ciliated cyst occurring in a male

Trotter, Spencer; Rassl, Doris M.; Saad, M.N.; Sharif, Hassan; Ali, M. A.

doi:10.1111/j.1365-2559.1994.tb00013.x

Cited by 22 publications

(20 citation statements)

References 4 publications

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“…The ''ciliated metaplasia of eccrine glands'' theory proposes that cilia are present in fetal eccrine ducts and is therefore possible for neoplasms of eccrine origin to acquire a ciliated epithelium. 5,9,11,[18][19][20][21][22] Examples of this manifestation are seen in some eccrine spiradenomas. 11,18 Numerous studies have shown immunohistochemical support for an eccrine origin in these lesions (ie, positive SMA and S100 staining for myoepithelial cells; positive CEA and GCDFP-15 staining for ductal epithelium origin; positive p63 staining).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Ciliated Cyst on the Finger

Hung

Yang²,

Binder³

et al. 2012

The American Journal of Dermatopathology

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As previously recognized by various authors, "cutaneous ciliated cyst" is a confusing term. Typically, the term refers to rare cystic lesions, commonly found on the lower limbs of women in their reproductive years. To date, 40 cases diagnosed as "cutaneous ciliated cyst" have been reported in the literature. Histologically, the cysts are composed of a simple layer of ciliated columnar cells along with nonciliated columnar cells, cuboidal cells, and round "peg-like" cells, resembling fallopian tube epithelium. This histology has been described in cysts found in males and females and in locations other than the lower limbs. Controversy has thus arisen over the etiology of these lesions, with some believing that the cysts arise from heterotopic Mullerian rests and others advocating for ciliated metaplasia of eccrine glands. We herein describe the first case of cutaneous ciliated cyst of Mullerian origin occurring on the dorsal thumb of a 16-year-old female. A review of literature shows that 2 groups of cysts are covered under the umbrella term "cutaneous ciliated cysts." We thus propose the abandonment of the confusing term "cutaneous ciliated cyst" and the adoption of "cutaneous Mullerian cysts" for estrogen receptor/progesterone receptor-positive lesions resembling simple fallopian tube epithelium and "Cutaneous ciliated eccrine cyst" for estrogen receptor/progesterone receptor-negative lesions usually occurring in males, which are immunohistochemically compatible with an eccrine origin.

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Section: Discussionmentioning

confidence: 99%

Cutaneous Ciliated Cyst on the Finger

Hung

Yang²,

Binder³

et al. 2012

The American Journal of Dermatopathology

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“…Rare case reports have demonstrated CCC to occur in men, with ciliated epithelium of simple, bilayered, or pseudostratified epithelium. 22,24,26,27 In the vast majority of these cases, hormone receptor expression was not explored. 23 This profile was reported to be most consistent with ciliated metaplasia of an eccrine sweat gland and has been supported by several other case reports.…”

Section: Discussionmentioning

confidence: 99%

PAX-8 Expression in Cutaneous Ciliated Cysts

Joehlin‐Price

Huang

Brooks

et al. 2014

The American Journal of Dermatopathology

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Cutaneous ciliated cysts (CCC) are exquisitely rare, benign cystic lesions demonstrating simple, ciliated epithelial linings reminiscent of fallopian tube epithelium. Most commonly, CCC show a predilection for the lower extremities of young reproductive age women and demonstrate immunohistochemical positivity for estrogen and progesterone receptors, supporting the theory that they are derived from ectopic Müllerian rests. PAX-8 is a paired box gene, important in the development of Müllerian and thyroid organs and has utility in the identification of tumors of Müllerian, renal, and thyroid origin. Prompted by the precedent studies on PAX-8 immunohistochemical expression in tumors of Müllerian origin, this article aimed to explore the utility of this antibody in defining the histogenesis of 2 bona fide cases of CCC, both occurring in young reproductive age women. Herein, 2 prototypic index cases of CCC with strong nuclear positivity for estrogen and progesterone receptors are shown to also have positive nuclear staining for PAX-8, further supporting their likely Müllerian origin. These data support the designation of these lesions as cutaneous Müllerian cysts, distinct from potential ciliated cysts of eccrine origin.

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“…La entidad típicamente aparece en extremidades inferiores y nalgas de mujeres en edad reproductiva 2,10,11 . En el sexo masculino la entidad es muy rara con sólo 6 casos descritos previamente [3][4][5][6][7]12 , sólo dos de ellos situados en la región perineal 7,12 sin que existan referencias previas en piel escrotal.…”

Section: Discusión Y Conclusionesunclassified

“…Esta última teoría se basó en el hecho de de que la mayoría de casos de esta entidad aparecen en extremidades inferiores de mujeres jóvenes 2 , el aspecto histológi-co y perfil inmunohistoquímico similar al del epitelio de la trompa de Falopio 11,15 y la presencia de receptores de hormonas esteroideas en el epitelio quístico 2,15 . No obstante la descripción de lesiones con idénticas características histológicas en varones [3][4][5][6][7]12 o en localizaciones anatómicas como espalda o cuero cabelludo 2,14 contradicen esta teoría. En su exhaustiva revisión de la entidad Fontaine et al proponen que los QCC de varones y de localizaciones atípicas en mujeres podrían corresponder a otra entidad patogénicamente diferente, en concreto a metaplasia ciliada de quiste ecrino, basando esta afirmación en que los cilios presentes en las células ductales ecrinas y en los tumores de diferenciación ecrina muestran características ultraestructurales diferentes a las de aquellos QCC en los que se han realizado estudios de microscopía electrónica 2 .…”

Section: Discusión Y Conclusionesunclassified

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Quiste cutáneo ciliado en piel escrotal: Descripción de un caso con discusión patogénica de la entidad

Valcárcel¹,

Currás²,

Arca³

et al. 2008

Actas Urol Esp

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RESUMEN QUISTE CUTÁNEO CILIADO EN PIEL ESCROTAL. DESCRIPCIÓN DE UN CASO CON DISCUSIÓNPATOGÉNICA DE LA ENTIDAD El quiste cutáneo ciliado (QCC) es una lesión benigna muy infrecuente, que aparece predominantemente en extremidades inferiores de mujeres jóvenes. En varones es una lesión aún más rara. En esta nota se presenta un caso de quiste cutáneo ciliado en piel escrotal de un varón de 15 años, se describen características histológicas e inmunohistoquímicas, se revisa la bibliografía al respecto y se realiza una discusión patogénica de la entidad. Se plantea que el QCC puede ser en realidad un patrón morfológico que engloba varias entidades patogénicamente diferentes. Los datos aportados en nuestro caso apoyan la teoría de que al menos un grupo de QCC, y en especial los acaecidos en pacientes de sexo masculino, podrían tener su origen en la metaplasia ciliada de glándulas sudoríparas apocrinas. ABSTRACT CUTANEOUS CILIATED CYST OF THE SCROTAL SKIN. A CASE REPORT WITH DISCUSSIONOF PATHOGENESIS Cutaneous ciliated cyst (CCC) is a rare benign lesion predominantly occurring in the lower limbs of young women and exceedingly rare in males. Here, we report a case involving a previously unreported site (i.e., scrotal skin) in a 15-year-old male. We also describe pathologic and immunonohistochemical findings, review the pertinent literature and discuss their pathogenetic mechanisms. We propose that CCC could represent a morphologic pattern encompassing several pathogenetically different entities. Data we provide support the hypothesis that at least a part of CCC, specially those occurring in males, could have their origin in ciliated metaplasia of apocrine sweat glands.

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Cutaneous ciliated cyst occurring in a male

Cited by 22 publications

References 4 publications

Cutaneous Ciliated Cyst on the Finger

Cutaneous Ciliated Cyst on the Finger

PAX-8 Expression in Cutaneous Ciliated Cysts

Quiste cutáneo ciliado en piel escrotal: Descripción de un caso con discusión patogénica de la entidad

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