Cutaneous Graft-versus-Host Disease

Aractingi, S.; Chosidow, Olivier

doi:10.1001/archderm.134.5.602

Cited by 185 publications

(192 citation statements)

References 69 publications

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“…Indeed, expression of E-selectin had been observed on epithelial cells histologically in patients with documented acute GVHD. [23][24][25] Unlike other histological reports, sICAM-1 levels in severe acute GVHD patients were significantly higher on days 30 and 60. sICAM-1 is thought to be shed as a result of activation of endothelial cells and immunocytes. 6,26 A significant increase in sE-selectin was observed in patients with extensive chronic GVHD.…”

Section: Discussioncontrasting

confidence: 55%

Serum levels of soluble adhesion molecules in stem cell transplantation-related complications

Matsuda

Hara

Osugi

et al. 2001

Bone Marrow Transplant

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Summary:To assess the involvement of vascular endothelial cell activation and damage in stem cell transplantation (SCT)-related complications, such as acute and chronic GVHD and thrombotic microangiopathy (TMA), we investigated the changes in serum levels of soluble forms of vascular cell adhesion molecule-1 (sVCAM-1) and Eselectin (sE-selectin) in SCT. The soluble form of intercellular adhesion molecule-1 (sICAM-1) was also analyzed. In patients with acute GVHD (grades II-IV), serum levels of sE-selectin and sICAM-1 increased around onset of GVHD (day 30). While the increase of sE-selectin levels was transient, sICAM-1 levels remained high until day 60. In patients with extensive chronic GVHD, sVCAM-1 as well as sE-selectin levels significantly increased. The appearance of clinical symptoms was preceded by elevations of sVCAM-1 and sE-selectin levels on day 60, and sICAM-1 levels on days 30 and 60. For the analysis of TMA, to exclude the influence of GVHD, serum levels were measured in auto-SCT patients. Around the onset of TMA, sVCAM-1 and sE-selectin levels significantly increased in patients with TMA without an increase of sICAM-1 levels. These findings support the notion that activation and injury of endothelium are commonly involved in the pathogenesis of acute and chronic GVHD and TMA. Bone Marrow Transplantation (2001) 27, 977-982.

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Section: Discussioncontrasting

confidence: 55%

Serum levels of soluble adhesion molecules in stem cell transplantation-related complications

Matsuda

Hara

Osugi

et al. 2001

Bone Marrow Transplant

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“…Six patients were scored as a "good" or "moderate" response, one was scored as a "mild" response, and three were scored as a "no" response. 4 Complete response A complete resolution of the oral GVHD…”

Section: Resultsmentioning

confidence: 99%

“…Keratinocytes are small, flattened and loaded with melanin. In the dermis there is a perivascular infiltrate [4]. Although some authors see the histological evaluation as an obligatory term for diagnosis of gastrointestinal GVHD [33], the diagnosis of cutaneous chronic GVHD can usually be based on the clinical examination of lichenoid or sclerodermatous lesions in a HSCT recipient [4].…”

Section: Discussionmentioning

confidence: 99%

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Topical tacrolimus-a novel treatment alternative for cutaneous chronic graft-versus-host disease

Resnick

Shapira

et al. 2003

Transplant Int

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Graft-versus-host disease (GVHD) may be resistant to accepted treatments. Therefore, the aim of the present preliminary study was to evaluate the efficacy of topical treatment with tacrolimus, an immunosuppressive agent, for cutaneous GVHD. Ten patients with chronic steroid-dependent cutaneous GVHD were treated with 0.03-0.1 % tacrolimus ointment, twice to three times a day. The dermal manifestations of GVHD were monitored, and a score was given to the cutaneous response by both the physician and patient. Seven patients demonstrated a response to the tacrolimus ointment. Three out of the ten patients were scored as showing a "good" or "complete" response in the objective examiner's view or subjective patient's view. Another four patients showed "moderate" or "mild" response; only three patients showed "no response". Topical tacrolimus is suggested as an alternative treatment for cutaneous chronic steroid-dependent GVHD. This conclusion concurs with a previous study on this medication.

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“…6 Lichenoid lesions usually affect the periorbital region, the ears, palms and soles. These lesions sometimes affect the external genitalia; female patients may present with vaginal stenosis.…”

Section: Discussionmentioning

confidence: 99%

Severe phimosis as a notable sequela of allogeneic stem cell transplantation in boys

Suzuki

Kobayashi

Kaneda

et al. 2007

Bone Marrow Transplant

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Hematopoietic SCT has improved the survival rates of patients with hematologic and metabolic disorders, as well as those with malignancy or immunodeficiency. Although various complications have been reported following allogeneic SCT, phimosis has rarely been reported, and the predisposing risk factors for phimosis have not been determined. In this study, the occurrence of severe phimosis following allogeneic SCT in boys was analyzed, and its risk factors were determined. The patients were under 15 years of age. Phimosis was observed in 32.6% of 46 patients after allogeneic SCT; 13.0% of cases required surgery. On univariate analysis, risk factors for severe phimosis included chronic GVHD and the use of a conditioning regimen including anti-thymocyte globulin (ATG). Multivariate analysis showed that chronic GVHD was an independent risk factor for severe phimosis. Thus, severe phimosis is an important complication of SCT in boys, especially in patients with chronic GVHD.

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Cutaneous Graft-versus-Host Disease

Cited by 185 publications

References 69 publications

Serum levels of soluble adhesion molecules in stem cell transplantation-related complications

Serum levels of soluble adhesion molecules in stem cell transplantation-related complications

Topical tacrolimus-a novel treatment alternative for cutaneous chronic graft-versus-host disease

Severe phimosis as a notable sequela of allogeneic stem cell transplantation in boys

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