Cutaneous Leishmaniasis after Travel to Cyprus and Successful Treatment with Miltefosine

Abstract

Abstract. A patient presenting with an atypical manifestation of cutaneous leishmaniasis after travel to Cyprus was successfully treated with miltefosine. The K26 typing revealed a hitherto undescribed strain of the Leishmania donovani/ infantum complex as the causing agent.

Disseminated cutaneous leishmaniasis in a kidney transplant recipient

“…Geographical variation in efficacy and susceptibility of Leishmania species is much higher for CL than VL 7 . Few reports of successful treatment of CL with miltefosine exist in renal transplant recipients 8 …”

“… 7 Few reports of successful treatment of CL with miltefosine exist in renal transplant recipients. 8 …”

“…7 Few reports of successful treatment of CL with miltefosine exist in renal transplant recipients. 8 Chrusciak et al conducted a randomized controlled trial about the efficacy and safety of miltefosine in the treatment of cutaneous Leishmaniasis caused by Leishmania Viannia in Brazil and reported a high cure rate and good tolerability. However, the enrolled patients were HIV-noninfected and immunocompetent.…”

Cutaneous leishmaniasis acquired during a brief visit to Cyprus

“…A further CL case in a traveller, following a 2-week stay in northern Cyprus was reported more recently. 5 However, under-reporting cannot be excluded, although leishmaniasis in both humans and dogs is a notifiable disease in Cyprus. Why a significant proportion of the canine population is infected with L. infantum, yet very few human cases of leishmaniasis are observed (and these due to L. donovani) is not clear.…”

Non-Endemic Leishmaniases Reported Globally in Humans between 2000 and 2021—A Comprehensive Review

“…Regarding clinical presentation (Table 5), OW disease presented as single lesions in 58.8% of cases, preferentially located in the head and neck (50.6%) (especially in the cheeks-13/36, [119,126,137,138,148,153,168,175,232,242,246]-and nose-12/36, [45,113,126,132,134,145,152,153,196,230,246]) with the region of the trunk being the least affected (2.0%). Patients presented ulcerated lesions in 56.1% of cases, but other lesion types were also frequently seen, namely papules (24.9%) and plaques (20.2%).…”