Cutaneous leishmaniasis

Adhikari, Ram Chandra; Shah, Mahesh

doi:10.3126/jpn.v7i2.18031

Cited by 6 publications

(17 citation statements)

References 12 publications

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“…In the present study, the disease was more common in males with male to female ra o of 1.7:1. This fi nding is similar to studies done by Aara N et al 9 and Srivastava et al 13 In contrast, other authors have found a higher incidence of disease in females. 11,12 In Nepal, females are mostly involved in household works and males are involved in outdoor works.…”

Section: Discussionsupporting

confidence: 92%

“…Most of our pa ents had single lesion which is similar to the fi nding of Aara N et al 9 and Galgamuwa LS et al 14 In our study, lesions were more common in face. Other authors have also reported similar fi ndings.…”

Section: Discussionsupporting

confidence: 90%

“…11 Similarly, some authors have found a higher incidence of cutaneous leishmaniasis in the 10-19 years age group. 9,12,13 The number of pa ents decreased with advancing age which may be due to acquired immunity.…”

Section: Discussionmentioning

confidence: 99%

“…Only few cases have been reported from Nepal. [3][4][5][6][7] It is a parasi c disease transmi ed by sandfl y infected with the protozoa Leishmania. Cutaneous leishmaniasis occurs at the site of inocula on.…”

Section: Introductionmentioning

confidence: 99%

“…Healed lesions o en leave residual atrophic scars. 9 In Nepal, the fi rst case of cutaneous leishmaniasis was reported in 2006 by Pandey BD et al 2 Since then the prevalence of the disease is slowly rising. Here we report a largest collec on of cases over the six years period.…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous Leishmaniasis: A Neglected Vector Borne Tropical Disease in Midwestern Region of Nepal

Ghimire

Shrestha

Pandey

et al. 2018

Nepal J Dermatol Venereol & Leprol

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Introduction: Cutaneous Leishmaniasis is a vector borne disease caused by the bite of an infected sandfly. The disease is rare in Nepal with only few cases reported till date. We report the largest collection of patients over six years.Objective: To describe the clinical, epidemiological and pathological aspect of Cutaneous Leishmaniasis in Midwestern region of Nepal Materials and Methods: Thirty-three patients referred to the department of Pathology for fine needle aspiration were diagnosed as Cutaneous leishmaniasis based on detection of Leishmania donovani in the fine needle aspiration smears. Demographic data and clinical details including site, size, and duration of disease onset were recorded on a printed proforma. Statistical analysis was done using SPSS version 16.0 for windows. Results:A total of 33 patients with age ranging from 11 years to 65 years were included in the study. Mean age was 26.5±11.5 years. Most patients were in the age group 21-40 years. Male: Female ratio was 1.7:1. Mean duration of disease was 5.3±4.4 months. Thirty patients had single lesion. Lesions were either of plaque type (84.9 %) or papulonodular type (15.1%). Conclusion:Cutaneous leishmaniasis is uncommon in Nepal. So, it is often neglected. It is in an increasing trend. Cutaneous leishmaniasis should be included in the differential diagnosis of a non-healing ulcer.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cutaneous Leishmaniasis: A Neglected Vector Borne Tropical Disease in Midwestern Region of Nepal

Ghimire

Shrestha

Pandey

et al. 2018

Nepal J Dermatol Venereol & Leprol

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Unusual Tumor on the Earlobe

2020

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A man in his 30s presented with a 3-month history of gradual growth of a pruriginous, reddish nodule on the left ear. He had no relevant medical history. On medical examination, a reddish, smooth, superficial nodule with small dimples and a soft consistency that measured approximately 1.5 cm in diameter was seen on the left earlobe (Figure , A). It was not painful to the touch. The patient reported no history of lesions or foreign bodies at this location. A biopsy specimen was obtained for histopathologic analysis (Figure, B and C).

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In vitro antileishmanial activities of hydro-methanolic crude extracts and solvent fractions of Clematis simensis fresen leaf, and Euphorbia abyssinica latex

Worku,

Araya,

Tesfa

et al. 2024

Medicine

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As a result of increasing drug resistance, crossover resistance development, prolonged therapy, and the absence of different agents with innovative methods for implementation, the efficacy of recent antileishmanial medications is severely declining. So, it is vital to look for other medications from botanical remedies that have antileishmanial activity. The latex of Euphorbia abyssinica (E abyssinica) and the leaves of Clematis simensis fresen (C simensis) were macerated in methanol (80%). In vitro antileishmanial activity of the preparation was tried on promastigotes of Leishmania aethiopica (L aethiopica) and Leishmania donovani (L donovani) using resazurin assay, and fluorescence intensity was measured. One percent of dimethyl sulfoxide (DMSO) and media as negative control and amphotericin B as positive control were used. Additionally, hemolytic & phytochemical tests of the preparation were done. The mean and standard errors of each extract were evaluated and interpreted for statistical significance using one-way analysis of variance. From sigmoidal dose-response curves of % inhibition, half maximal inhibitory concentration (IC50) values were determined by GraphPad Prism and Microsoft Excel; outcomes were presented as mean ± standard error of mean of triplicate trials. P < .05 was statistical significance. The phytochemical screening of C simensis and E abyssinica confirmed the existence of steroids, phenols, tannins, saponins, alkaloids, terpenoids, flavonoids and glycosides. C simensis possesses antileishmanial activity with IC50 outcomes of 46.12 ± 0.03 and 8.18 ± 0.10 µg/mL on the promastigotes of L aethiopica and L donovani, respectively. However, E abyssinica showed stronger activity with IC50 outcomes of 16.07 ± 0.05 µg/mL and 4.82 ± 0.07 µg/mL on L aethiopica and L donovani, respectively. C simensis and E abyssinica have a less hemolytic effect on human red blood cells at low concentrations. The outcomes from this investigation demonstrated that the preparation of C simensis and E abyssinica indicated significant antileishmanial activity. Therefore, further in vivo assessment of antileishmanial, cytotoxicity activity and quantitative identification of secondary metabolites are highly recommended.

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Cutaneous leishmaniasis

Cited by 6 publications

References 12 publications

Cutaneous Leishmaniasis: A Neglected Vector Borne Tropical Disease in Midwestern Region of Nepal

Cutaneous Leishmaniasis: A Neglected Vector Borne Tropical Disease in Midwestern Region of Nepal

Unusual Tumor on the Earlobe

In vitro antileishmanial activities of hydro-methanolic crude extracts and solvent fractions of Clematis simensis fresen leaf, and Euphorbia abyssinica latex

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