Cutaneous lymphoid hyperplasia: a lymphoproliferative continuum with lymphomatous potential

Nihal, Minakshi; Mikkola, Debra; Horvath, Nancy; Gilliam, Anita C.; Stevens, Seth R.; Spiro, Timothy; Cooper, Kevin D.; Wood, Gary S.

doi:10.1016/s0046-8177(03)00075-3

Cited by 114 publications

(122 citation statements)

References 24 publications

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“…It has been suggested that between the groups of cutaneous lymphomas on one end and cutaneous pseudolymphomas on the other, a category designated as ‘clonal cutaneous lymphoid hyperplasia’ or ‘cutaneous lymphoid dyscrasia’ can be identified [21, 22]. This cutaneous lymphoproliferative disorder is described as a ‘borderline’ condition with some potential for evolution into malignant lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Solitary Small- to Medium-Sized Pleomorphic T-Cell Nodules of Undetermined Significance: Clinical, Histopathological, Immunohistochemical and Molecular Analysis of 26 Cases

Leinweber

Beltraminelli²,

Kerl³

et al. 2009

Dermatology

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Background: Solitary skin nodules composed of pleomorphic T lymphocytes are often the source of diagnostic problems. Objective: To characterize the clinicopathological features, prognosis and optimal treatment modalities of patients with solitary lymphoid nodules of small- to medium-sized pleomorphic T lymphocytes. Methods: Twenty-six patients were analysed for clinical, histopathological, immunophenotypical, molecular and follow-up data. Results: Lesions were located mainly on the head and neck (n = 16; 61.5%) or trunk (n = 8; 30.8%). Histopathology showed non-epidermotropic nodular or diffuse infiltrates of small- to medium-sized pleomorphic T lymphocytes. Monoclonality was found by PCR in 54.2% of cases (n = 13/24). After a mean follow-up of 79.7 months, a local recurrence could be observed only in 1 patient. Conclusions: Our patients have a specific cutaneous lymphoproliferative disorder characterized by reproducible clinicopathological features. The incongruity between the indolent clinical course and the worrying histopathological features poses difficulties in classifying these cases unambiguously as benign or malignant. We suggest to describe these lesions as ‘solitary small- to medium-sized pleomorphic T-cell nodules of undetermined significance’. Irrespective of the name given to these equivocal cutaneous lymphoid proliferations, follow-up data support a non-aggressive therapeutic strategy.

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Section: Discussionmentioning

confidence: 99%

Solitary Small- to Medium-Sized Pleomorphic T-Cell Nodules of Undetermined Significance: Clinical, Histopathological, Immunohistochemical and Molecular Analysis of 26 Cases

Leinweber

Beltraminelli²,

Kerl³

et al. 2009

Dermatology

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“…It is formed by the aggregation of lymphocytes in the skin in response to various stimuli. Various factors such as foreign antigens, arthropod bites and infestations, tattoos, vaccinations, traumas, impurity injection, and drugs may play a role in the formation and it may also occur idiopathically (4). There was no etiological cause in our case.…”

Section: Discussionmentioning

confidence: 60%

“…Although they are defined as benign lesions, even cases showing progression to lymphoma have been reported in the literature (5). Therefore, these lesions should be distinguished from cutaneous lymphomas with histopathological studies (4,6).…”

Section: Discussionmentioning

confidence: 99%

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Nasal Pseudolymphoma

Yıldız¹,

Server²,

Yiğit³

et al. 2016

Istanbul Med J

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Pseudolymphoma (cutaneous lymphoid hyperplasia) caused by various antigenic stimulations in which benign proliferation of polyclonal T and B lymphocytes is observed. Pseudolymphoma lesions have similar clinical and histopathological findings to those of cutaneous lymphoma. Some studies have reported the conversion potential of pseudolymphomas to cutaneous lymphomas. Nasal Pseudolymphoma etiology, clinical features, diagnosis and therapy is discussed in male patients diagnosed with spontaneous Pseudolymphoma at the age of 45.

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“…17 Cutaneous pseudolymphoma refers to a heterogeneous group of benign reactive T-cell and B-cell lymphoproliferative processes of diverse causes, which can simulate cutaneous lymphomas in which the reactive inflammatory infiltrates may occasionally simulate lymphoma. 1,2,18 The common feature of CPL that distinguishes it from other benign inflammatory cell infiltrates in the skin is the presence of variable numbers of medium to large sized lymphocytes, which may appear atypical, alongside many ordinary small lymphocytes and other inflammatory cells. Depending on the cause, this lymphocytic infiltrate may consist particularly of B-or T-cell, in most cases -mixture of B-and T-cells, macrophages and dendritic cells.…”

Section: -14mentioning

confidence: 99%

A Rare Kind of Lymphoma in a Patient on Treatment With Two Different Biological Agents

et al. 2015

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Cutaneous lymphoid hyperplasia: a lymphoproliferative continuum with lymphomatous potential

Cited by 114 publications

References 24 publications

Solitary Small- to Medium-Sized Pleomorphic T-Cell Nodules of Undetermined Significance: Clinical, Histopathological, Immunohistochemical and Molecular Analysis of 26 Cases

Solitary Small- to Medium-Sized Pleomorphic T-Cell Nodules of Undetermined Significance: Clinical, Histopathological, Immunohistochemical and Molecular Analysis of 26 Cases

Nasal Pseudolymphoma

A Rare Kind of Lymphoma in a Patient on Treatment With Two Different Biological Agents

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