Cutaneous manifestations in celiac disease

Abstract

Celiac disease (CD) is an autoimmune gluten-dependent enteropathy characterized by atrophy of intestinal villi that improves after gluten-free diet (GFD). CD is often associated with extra-intestinal manifestations; among them, several skin diseases are described in CD patients. The present review reports all CD-associated skin manifestations described in the literature and tries to analyze the possible mechanisms involved in this association. The opportunity to evaluate the possible presence of CD in patients affected by skin disorders is discussed.

Celiac Disease and Autoimmunity in the Gut and Elsewhere

“…[44] DH is strongly associated with CD, tends to be more prevalent in males, and manifests as extremely pruritic, blistering lesions on the extensor surfaces of the extremities as well as back and buttocks; data from Finnish centers have shown that 1 in 4 CD patients are affected by DH. [45] A recent large, retrospective study by Alonso-Llamazares et al found a 12.6% prevalence rate of CD and 22% prevalence rate of systemic autoimmune disorders among 263 DH patients.…”

IgA Nephropathy, Celiac Disease and Dermatitis Herpetiformis: A Rare Triad

“…It is the most common feeding intolerance in the occidental population and its estimated prevalence is 0.5% to 1% in the general population and 3 to 13 cases per 1000 children [13]. In its classical presentation the beginning of CD symptoms occurs generally in 6 to 24 months old children and is characterized by chronic diarrhea, abdominal pain, abdominal distension, insufficient growth, anorexia and vomiting [15]. This was very much distinct in our 2 year male child.…”

“…However, many individuals can be asymptomatic and are diagnosed only after years of silent disease [13]. Atypical manifestation of CD includes extra intestinal changes as iron-deficient anaemia, osteoporosis, and cutaneous and neurological manifestations [15]. Our patient was anaemic too.…”

“…Individuals with this disease have permanent intolerance to the gliadin in fraction of wheat, barley and rye proteins [12][13][14][15]. It is the most common feeding intolerance in the occidental population and its estimated prevalence is 0.5% to 1% in the general population and 3 to 13 cases per 1000 children [13].…”

Prevalence of mucocutaneous findings in Celiac disease patients

“…Aynı zamanda hastalığın kliniğinde gastrointestinal sistem dışı bulgular da görülebilir 7 . Çölyak hastalarında dermatitis herpetiformis, vitiligo, psoriasis, rekürren aftöz stomatit gibi immün aracılı bazı dermatolojik hastalıkların sıklığının arttığı bildirilmektedir [8][9][10] . Ayrıca çölyak hastalarında malnutrisyon gibi komplikasyonlara bağlı bazı deri bulguları oluşabilir 11 .…”