Cutaneous metastasis as the first clinical manifestation of pancreatic adenocarcinoma: A case treated with gemcitabine

Takemura, Noriko; Fujii, Norikazu; Tanaka, Toshihiro

doi:10.1111/j.1346-8138.2007.00353.x

Cited by 13 publications

(5 citation statements)

References 7 publications

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“…Pancreatic cancer has the ability to metastasize to all cutaneous tissue, most frequently to the umbilicus. Non-umbilical cutaneous nodules have also been observed on the scalp ( 4 ), neck ( 14 ), temple ( 5 ), thorax, epigastric region and axilla ( 15 , 16 ). Local surgery is closely associated with the site of the cutaneous metastases of pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

“…The occurrence of cutaneous metastases is rare, predominantly presenting in close proximity to the umbilicus and is termed Sister Mary Joseph’s nodule (SMJN) ( 3 ). Non-umbilical cutaneous metastases are rare, with only a small number of cases reported ( 4 , 5 ). The present report describes a case of multiple cutaneous metastatic lesions associated with pancreatic cancer, reviews the published literature regarding cutaneous metastasis from pancreatic cancer (by conducting a detailed PubMed search).…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous metastasis from pancreatic cancer: A case report and systematic review of the literature

et al. 2014

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Cutaneous metastasis from pancreatic cancer is uncommon, therefore, the outcome of this progression has rarely been investigated. The aim of the present report was to evaluate the clinical characteristics of patients exhibiting cutaneous metastasis from pancreatic cancer. Thus, the current report presents a rare case of cutaneous metastatic disease from pancreatic cancer and describes a systematic review of the literature. A total of 54 articles comprising 63 cases were included for analysis. The relevant clinical and pathological characteristics, as well as the treatment strategies and survival outcomes of this rare disease presentation were reviewed. The average patient was was aged 63.9 years and males constituted a marginally greater proportion of the cohort (61.9%). The predominant manifestation of the cutaneous metastasis was a nodule or mass (73%) and the most common site of the skin lesion was non-umbilicus rather than umbilicus. The majority (66.7%) of the skin lesions were singular, particularly in patients exhibiting Sister Mary Joseph’s nodule (90%). A wide range of histological subtypes presented, with a predominance of adenocarcinoma (84.1%). Of the cases that specified the tumor differentiation grade, 78.2% were moderately or poorly differentiated. Immunohistochemistry revealed that cytokeratin (CK)20-negative, and CK7-, CK19- and carbohydrate antigen (CA)19-9-positive were specific diagnostic markers for pancreatic cancer. Distal metastases, excluding the skin, were observed in 68.3% of patients and the median survival period was 5 months. Treatment strategies including surgery, radiation, chemotherapy or a combination improved survival time from 3.0 to 8.3 months. Cutaneous metastasis from pancreatic cancer is a rare finding, often providing the only external indication of an internal malignancy and, therefore, should be considered in the differential diagnosis of skin lesions. Metastasis to the skin indicates a widespread, general dissemination and a poor prognosis. A combination of surgery, radiotherapy and chemotherapy appears to result in improved survival rates.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cutaneous metastasis from pancreatic cancer: A case report and systematic review of the literature

et al. 2014

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“…Our case is unique in that cutaneous metastases were extensive in several parts of the lower trunk and developed gradually during the course of the disease. No more than 26 cases of non‐periumbilical skin metastasis in PDA have been described worldwide since 1959 (Table ). In addition, this report is the only one presenting a case of scrotum metastasis.…”

Section: Discussionmentioning

confidence: 99%

Extensive cutaneous metastases of pancreatic adenocarcinoma: a case report and review of the literature

Kotsantis

Economopoulou

Dritsakos

et al. 2016

Clinical Case Reports

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“…Chronic pancreatitis is described on rare occasions as a disease linked to livedo reticularis 37 . A case report of a patient with chronic pancreatitis described relapsing patients with pancreatic neuroendocrine tumors, even before definitive diagnosis 41 .…”

Section: Livedo Reticularismentioning

confidence: 99%

Skin manifestations of pancreatic diseases

Kunovský¹,

Dítě²,

Březinová³

et al. 2022

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Although symptoms of pancreatic diseases such as pancreatitis, acute and chronic and, carcinoma of the pancreas are mainly gastrointestinal in nature, the extra-pancreatic symptoms are also important. These include skin symptoms, such as pancreatic panniculitis, acanthosis nigricans, livedo reticularis, necrolytic migratory erythema, cutaneous signs of hemorrhage, as in persons with severe acute pancreatitis, or the finding of cutaneous metastases of pancreatic carcinoma, which may be a sign of advanced disease. The pancreas is therefore one of those organs for which diagnosis and therapy are often multidisciplinary. In this review article, we summarize current knowledge of the possible skin manifestations of pancreatic disorders.

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Cutaneous metastasis as the first clinical manifestation of pancreatic adenocarcinoma: A case treated with gemcitabine

Cited by 13 publications

References 7 publications

Cutaneous metastasis from pancreatic cancer: A case report and systematic review of the literature

Cutaneous metastasis from pancreatic cancer: A case report and systematic review of the literature

Extensive cutaneous metastases of pancreatic adenocarcinoma: a case report and review of the literature

Skin manifestations of pancreatic diseases

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