Cutaneous Metastasis

Strickley, John; Jenson, A. Bennett; Jung, Jisun

doi:10.1016/j.hoc.2018.08.008

Cited by 38 publications

(123 citation statements)

References 52 publications

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“…Cutaneous metastases occur in up to one-third of all patients with breast cancer and are usually a sign of poor prognosis [1]. Cutaneous metastases of breast cancer (CMOBC) have a major impact on the quality of life of the patient and often represent difficult therapeutic challenges.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Breast Cancer Metastases Successfully Treated Using an Oxygen Flow Assisted Topical Administration of Methotrexate (OFAMTX)

Jouret

Gonne

Quatresooz

et al. 2020

Dermatol Ther (Heidelb)

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Introduction: Cutaneous metastases of breast cancer remain a therapeutic challenge. Oxygen flow-assisted topical administration of methotrexate 5% (OFAMTX, 5% methotrexate in a carrier solution) has recently been proven to be an efficacious alternative treatment for extramammary Paget's disease, which is considered to be an in situ mammary adenocarcinoma of the epidermis. Case Report: A 51-year-old patient with triple negative breast cancer presenting with biopsyproven skin metastases on the chest agreed to a treatment with OFAMTX5%. The treatment duration was 2 weeks and consisted of twiceweekly sessions with OFAMTX5% applied to an area of skin of approximately 40 cm 2. Skin biopsies were performed before and 2 months Digital Features To view digital features for this article go to

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Section: Introductionmentioning

confidence: 99%

Cutaneous Breast Cancer Metastases Successfully Treated Using an Oxygen Flow Assisted Topical Administration of Methotrexate (OFAMTX)

Jouret

Gonne

Quatresooz

et al. 2020

Dermatol Ther (Heidelb)

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“…Cutaneous metastases of breast cancer (CMOBC) may occur in up to 1/3 of patients and are usually a sign of poor prognosis (1).. They present an important impact on the quality of life and can present difficult therapeutic challenges.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous breast cancer metastases successfully treated using an oxygen flow assisted administration of methotrexate (OFAMTX5%)

Jouret

Gonne

Quatresooz

et al. 2020

Preprint

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Introduction: Cutaneous metastases of breast cancer (CMOBC) remain a therapeutic challenge. Recently, oxygen flow assisted topical administration of methotrexate 3% (OFAMTX5%) was proven an efficacious alternative treatment for extramammary Paget’s disease, an in situ mammary adenocarcinoma. Aim: To evaluate the efficacy and tolerance of OFAMTX5% for the treatment of CMOBC. Materials and methods: A patient with triple negative breast cancer presented with biopsy proven CMOBC. Two weekly sessions were given for 2 weeks with OFAMTX5% on a site of approximately 40 cm 2 . Skin biopsies were performed before and 2 months after procedure. Results: Tolerance was excellent with no pain sensations. Two months post procedure the treated area presented a postinflammatory hyperpigmentation. No residual metastases were evidenced on the control skin biopsy. Discussion: In selected cases of CMOBC OFAMTX5% can represent a non-painfull and efficacious treatment alternative. Larger series should evaluate the place of OFAMTX5% for the treatment of CMOBC.

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“…1 Breast cancer and melanoma are the most frequent sources of cutaneous metastases. 2 Cutaneous metastases of the breast carcinoma may present with a broad spectrum of clinical and histological appearances that lead to diagnostic challenges for dermatologists. 2 Because of the potential implications for prognosis and management, the early diagnosis of such lesions is crucial.…”

mentioning

confidence: 99%

“…2 Cutaneous metastases of the breast carcinoma may present with a broad spectrum of clinical and histological appearances that lead to diagnostic challenges for dermatologists. 2 Because of the potential implications for prognosis and management, the early diagnosis of such lesions is crucial. Pigmented cutaneous metastasis is a rare cutaneous manifestation of an underlying breast malignancy that can be difficult to differentiate from cutaneous melanoma.…”

mentioning

confidence: 99%

“…erythematous infiltrating nodules that might also show a zosteriform pattern, carcinoma erysipeloides, carcinoma encuirasse, carcinoma telangiectaticum, or alopecia neoplastica. 2 Pigmented cutaneous metastasis of breast carcinoma is a rare clinical presentation that leads to difficulties differentiating from melanoma not only clinically and dermatoscopically but also histopathologically. [3][4][5][6][7] To our knowledge, there have been very little data on the dermatoscopic findings of skin metastases, and the pigmented forms are one of the rarest.…”

mentioning

confidence: 99%

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