Cutaneous Metastatic Breast Cancer Masked by Hidradenitis Suppurativa

Cohen-Kurzrock, Rena A; Riahi, Ryan R

doi:10.7759/cureus.12862

Cited by 6 publications

(10 citation statements)

References 12 publications

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“…The morphology of metastatic skin lesions from breast carcinoma is diverse (Table 1) [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The most common presentation of breast cancer cutaneous metastases are nodules on the ipsilateral chest wall and breast; however, the skin metastases can also appear as papules or plaques.…”

Section: Discussionmentioning

confidence: 99%

“…Reactive erythema [3,14,15] CR Annular erythema [3] CR Erythema annulare centrifugum [3,14] Urticaria [15] Skin conditions [1][2][3][4]16,17] CR Alopecia [2,3,16] Carcinoma en cuirasse [2,3] CR Dermatitis [1,3,4] CR Hidradenitis suppurativa [17] Unique locations [1][2][3][4]13] CR Eyelids [3,4] Inframammary folds [1,3,4] Lymphedematous arm [2] Radiation therapy port [2] CR…”

Section: Condition Referencesmentioning

confidence: 99%

“…Carcinoma en cuirasse skin metastases from breast cancer can masquerade as scleroderma. In addition, metastatic breast cancer can mimic alopecia areata, dermatitis, and hidradenitis suppurativa [1][2][3][4]16,17].…”

Section: Table 1: Breast Cancer Cutaneous Metastases: Mimicking Conditions and Skin Manifestations Cr: Case Reportmentioning

confidence: 99%

“…It is also a common neoplasm associated with cutaneous metastases. The morphology of the skin lesions secondary to metastatic breast cancer is variable in appearance [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

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Pleomorphic Appearance of Breast Cancer Cutaneous Metastases

Cohen¹

2021

Cureus

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Cutaneous metastases occur in approximately 10% of oncology patients as a feature of a persistent solid tumor or the harbinger of recurrent neoplastic disease. However, they can be the presenting manifestation of an unsuspected visceral malignancy in one percent of previously cancer-free individuals. Metastatic skin lesions from breast carcinoma are diverse in their appearance. The clinical presentation of cutaneous metastases in three women with breast cancer is described and both the morphology of skin metastases caused by breast carcinoma and the conditions that are mimicked by breast cancer cutaneous metastases are reviewed. Skin metastases from breast carcinoma commonly appear as firm, flesh-colored to red, smooth or ulcerated or crusted, nodules, papules, and plaques on the ipsilateral chest wall and breast. However, unique sites of breast cancer cutaneous metastases are the eyelids, inframammary folds, ipsilateral lymphedematous arm, scalp, subungual nail bed, and umbilicus; in addition, skin metastases can occur in mastectomy scars and radiation therapy ports. Carcinoma erysipelatoides, carcinoma telangiectoides, and carcinoma en cuirasse are classic patterns of skin metastases that can be observed in breast cancer patients; carcinoma hemorrhagiectoides is a recently observed skin metastases pattern that has also been noted in oncology patients with breast carcinoma. The pleomorphic skin lesions of breast cancer metastases can masquerade as benign cutaneous lesions and tumors (such as a collision tumor, cyst, dermatofibroma, and milia-en-plaque), cutaneous malignancies (such as melanoma and non-melanoma skin cancers), infections (such as cellulitis, folliculitis, herpes zoster, and paronychia), reactive erythema (such as erythema annulare centrifugum, and urticaria), skin conditions (such as alopecia areata, dermatitis, hidradenitis suppurativa, and scleroderma), and vascular lesions (such as angiokeratoma, angiosarcoma, lymphangioma circumscriptum, purpura, and pyogenic granuloma). In addition, breast carcinoma cutaneous metastases can not only mimic other miscellaneous conditions such as erosions and ulcers, Paget's disease, and papillomatosis cutis lymphostatica but also have unusual morphology such as targetoid lesions or a sharply demarcated red infiltration of the nasal tip similar to a clown's nose. The possibility of a breast cancer cutaneous metastasis should be considered in the evaluation of a patient with breast cancer--and although less likely, in a cancer-free individual--who develops a new and/or a treatment-unresponsive cutaneous lesion. A biopsy of the skin lesion is necessary to confirm the diagnosis of breast cancer cutaneous metastasis.

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Section: Discussionmentioning

confidence: 99%

Section: Condition Referencesmentioning

confidence: 99%

Section: Table 1: Breast Cancer Cutaneous Metastases: Mimicking Conditions and Skin Manifestations Cr: Case Reportmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pleomorphic Appearance of Breast Cancer Cutaneous Metastases

Cohen¹

2021

Cureus

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“…We identified three articles reporting cases of cutaneous metastasis of OBC by using the following search strategy on PubMed: "skin AND occult AND metastasis AND breast AND cancer" [ 3 , 10 , 11 ] ( Table 1 ). In the three other cases identified in PubMed, patients had a more aggressive disease than the patient described in this case report, requiring more robust treatment strategies, such as mastectomy, chemotherapy and radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous metastasis of occult breast cancer: a case report

Costa¹,

Reis²,

Moura³

et al. 2021

Pan Afr Med J

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Occult breast cancer (OBC) is characterized by metastatic presentation of undetectable breast tumor on imaging exams. OBC is a rare disease (accounting for 0.3% to 1.0% of all breast cancers) that represents a major diagnostic challenge. The aim of this study was to report a case of OBC with primary presentation of multiple cutaneous metastases with subsequent emergence of bone metastasis. A 70-year female patient had multiple cutaneous metastatic lesions in the left cervical region, left breast, left axillary region, left subscapular region, in three chirodactylus of the right hand and three chirodactylus of the left hand. Imaging tests (mammogram, ultrasonography and magnetic resonance imaging of the breast) did not show alterations. Biopsy, histology sections and immunohistochemistry of the left cervical cutaneous lesion were compatible with OBC. After two years of anastrozole treatment (1mg/day), there was regression of all cutaneous lesions and stabilization of bone metastasis. OBC has a better prognosis. It may exhibit spontaneous regression or respond to less aggressive treatment strategies, as described in this case.

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Hidradenitis suppurativa of the breast: a diagnostic dilemma

Fahrenhorst-Jones

Theodore

Dauway

2023

Journal of Surgical Case Reports

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Hidradenitis suppurativa (HS) is a chronic skin condition characterised by recurrent abscesses, nodules, sinus tracts and fistulas. The condition has a known diagnostic delay and well-documented negative effect on the quality of life of patients. When affecting the periareolar region, there is a capacity for confusion with other more mainstream surgical conditions of the breast. We present a case of a 35-year-old woman who was diagnosed with an acutely painful breast nodule with periareolar erythema and induration who was repeatedly misdiagnosed due to cofounding features on clinical assessment. We present this case as a diagnostic dilemma to raise awareness of HS as a differential when assessing surgical breast patients.

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Cutaneous Metastatic Breast Cancer Masked by Hidradenitis Suppurativa

Cited by 6 publications

References 12 publications

Pleomorphic Appearance of Breast Cancer Cutaneous Metastases

Pleomorphic Appearance of Breast Cancer Cutaneous Metastases

Cutaneous metastasis of occult breast cancer: a case report

Hidradenitis suppurativa of the breast: a diagnostic dilemma

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