Cutaneous pancreatic metastasis: A case report and review of literature

Hafez, Hisham Z Abdel

doi:10.4103/0019-5154.44806

Cited by 12 publications

(6 citation statements)

References 8 publications

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“…Cutaneous metastases from PC have been reported in multiple case reports in the literature 6–11 . Horino et al reviewed 42 cases of pancreatic metastasis in the literature from 1950 to 2011, with the majority of patients presenting with umbilical cutaneous metastases and presenting predominantly with subcutaneous nodules, 19 consistent with the results from our study.…”

Section: Discussionsupporting

confidence: 89%

“…Our understanding of the pathobiology of PC and cutaneous metastases is primarily based on single case descriptions in the literature 6–11 . The most common site of cutaneous metastasis of PC is the umbilicus, also referred to as ‘Sister Mary Joseph's nodule’ 12 .…”

Section: Introductionmentioning

confidence: 99%

“…4 Our understanding of the pathobiology of PC and cutaneous metastases is primarily based on single case descriptions in the literature. [6][7][8][9][10][11] The most common site of cutaneous metastasis of PC is the umbilicus, also referred to as 'Sister Mary Joseph's nodule'. 12 There is disagreement as to whether these lesions represent cutaneous or deeperseated peritoneal lesions that spread to the umbilicus.…”

Section: Introductionmentioning

confidence: 99%

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Pancreatic cancer: Cutaneous metastases, clinical descriptors and outcomes

Mehta

Rao

et al. 2022

Cancer Medicine

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Background Cutaneous metastases in pancreatic cancer (PC) are rare. Herein, we evaluate the clinical, genomic, and other descriptors of patients with PC and cutaneous metastases. Methods Institutional databases were queried, and clinical history, demographics, PC cutaneous metastasis details, and overall survival (OS) from cutaneous metastasis diagnosis were abstracted. OS was estimated using Kaplan–Meier methods. Results Forty patients were identified, and median age (Q1–Q3, IQR) of PC diagnosis was 66.0 (59.3–72.3, 12.9) years. Most patients had Stage IV disease at diagnosis ( n = 26, 65%). The most common location of the primary tumor was the tail of the pancreas ( n = 17, 43%). The most common cutaneous metastasis site was the abdomen ( n = 31, 78%), with umbilical lesions occurring in 74% ( n = 23) of abdominal lesions. The median OS (95% CI) was 11.4 months (7.0, 20.4). Twenty‐three patients had umbilical metastases (58%), and 17 patients had non‐umbilical metastases (43%). The median OS (95% CI) was 13.7 (7.0, 28.7) months in patients with umbilical metastases and 8.9 (4.1, Not reached) months in patients with non‐umbilical metastases ( p = 0.1). Sixteen of 40 (40%) patients underwent somatic testing, and findings were consistent with known profiles. Germline testing in 12 (30%) patients identified pathogenic variants in patients: CHEK2 , BRCA1, and ATM. Conclusion Cutaneous metastases from PC most frequently arise from a pancreas tail primary site and most frequently occur in the umbilicus. Cutaneous metastases may generally be categorized as umbilical or non‐umbilical metastases.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pancreatic cancer: Cutaneous metastases, clinical descriptors and outcomes

Mehta

Rao

et al. 2022

Cancer Medicine

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“…Pancreatic carcinoma is the most common cause of cancer-related mortality worldwide. The primary reason for the poor outcome in pancreatic carcinoma patients is the presence of extensive local tumor invasion and frequent spread to metastatic sites, particularly the lymph nodes[ 17 ].…”

Section: Introductionmentioning

confidence: 99%

CCL21/CCR7 Axis Contributed to CD133+ Pancreatic Cancer Stem-Like Cell Metastasis via EMT and Erk/NF-κB Pathway

Zhang

Wang

et al. 2016

PLoS ONE

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BackgroundTumor metastasis is driven by malignant cells and stromal cell components of the tumor microenvironment. Cancer stem cells (CSCs) are thought to be responsible for metastasis by altering the tumor microenvironment. Epithelial-mesenchymal transition (EMT) processes contribute to specific stages of the metastatic cascade, promoted by cytokines and chemokines secreted by stromal cell components in the tumor microenvironment. C-C chemokine receptor 7 (CCR7) interacts with its ligand, chemokine ligand 21(CCL21), to mediate metastasis in some cancer cells lines. This study investigated the role of CCL21/CCR7 in promoting EMT and metastasis of cluster of differentiation 133+ (CD133+) pancreatic cancer stem-like cells.MethodsPanc-1, AsPC-1, and MIA PaCa-2 pancreatic cancer cells were selected because of their aggressive invasive potentials. CCR7 expression levels were examined in total, CD133+ and CD133− cell fractions by Immunofluorescence analysis and real time-quantitative polymerase chain reaction (RT-qPCR). The role of CCL21/CCR7 in mediating metastasis and survival of CD133+ pancreatic cancer stem-like cells was detected by Transwell assays and flow cytometry, respectively. EMT and lymph node metastasis related markers (E-cadherin, N- cadherin, LYVE-1) were analyzed by western blot. CCR7 expression levels were analyzed by immunohistochemical staining and RT-qPCR in resected tumor tissues, metastatic lymph nodes, normal lymph nodes and adjacent normal tissues from patients with pancreatic carcinoma.ResultsCCR7 expression was significantly increased in CD133+ pancreatic cancer stem-like cells, resected pancreatic cancer tissues, and metastatic lymph nodes, compared with CD133− cancer cells, adjacent normal tissues and normal lymph nodes, respectively. CCL21/CCR7 promoted metastasis and survival of CD133+ pancreatic cancer stem-like cells and regulated CD133+ pancreatic cancer stem-like cells metastasis by modulating EMT and Erk/NF-κB pathway.ConclusionsThese results indicate a specific role for CCL21/CCR7 in promoting EMT and metastasis in CD133+ pancreatic cancer stem-like cells. Furthermore the data also indicated the potential importance of developing therapeutic strategies targeting cancer stem-like cells and CCL21/CCR7 for reducing metastasis.

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“…This could be related to the tendency of tail of pancreas cancers to remain asymptomatic until the advanced stage of the disease, when distant metastasis has already occurred. In contrast, non-umbilical cutaneous metastases are more common in adenocarcinoma involving the head of the pancreas [ 12 ] - perhaps due to a predominantly different route of metastatic spread. In general, pancreatic cancers with cutaneous metastases tend to be moderately or poorly differentiated [ 3 ], possibly due to these tumor cells expressing a more aggressive, invasive phenotype [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Sister Mary Joseph Nodule and Concomitant Pancreatitis as Initial Presentation of Pancreatic Adenocarcinoma – Case Report and Review of the Literature

Dharan¹,

Ryan-Fisher²

2021

Cureus

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Umbilical metastasis [Sister Mary Joseph Nodule (SMJN)] is a rare presentation of visceral abdominal/pelvic malignancy. It is less commonly seen in metastatic pancreatic adenocarcinoma and there are only over a hundred cases to date in the literature on this topic. This article highlights a case of metastatic pancreatic adenocarcinoma presenting as SMJN and concomitant pancreatitis (which to the best of our knowledge is the first such report to date) with discussions regarding the etiopathogenesis of this phenomenon and presents a brief literature review on pancreatic adenocarcinoma presenting as SMJN.

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Cutaneous pancreatic metastasis: A case report and review of literature

Cited by 12 publications

References 8 publications

Pancreatic cancer: Cutaneous metastases, clinical descriptors and outcomes

Pancreatic cancer: Cutaneous metastases, clinical descriptors and outcomes

CCL21/CCR7 Axis Contributed to CD133+ Pancreatic Cancer Stem-Like Cell Metastasis via EMT and Erk/NF-κB Pathway

Sister Mary Joseph Nodule and Concomitant Pancreatitis as Initial Presentation of Pancreatic Adenocarcinoma – Case Report and Review of the Literature

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