Cutaneous Pili Migrans

Tufted cutaneous pili migrans

“…1 A limited number of cases of combined use of MTX and ACI have been reported to date. [1][2][3] Although these reports are not suggestive of a safety issue, more data are needed to help address the theoretical concerns on the hepatic safety of these drugs. We searched the electronic health records of all patients who had contact with our two dermatology departments during the period 2016-2020 to identify patients treated concurrently with MTX and ACI.…”

“…Our findings are in agreement with those of previously published cases that support no increased risk of liver toxicity with combined use of MTX and ACI. [1][2][3] The authors of one case report concluded that the possibility of toxic hepatitis due to combined use of MTX and the formerly used first-generation retinoid, etretinate (a pro-drug of ACI) could not be excluded, 4 but other authors did not observe a hepatotoxic effect. 1 A central pharmacokinetic difference between etretinate and the second-generation retinoid ACI is that ACI has a shorter half-life (49 vs. 120 h) and does not accumulate in the adipose tissue, which would increase the risk of a prolonged systemic AE.…”

“…1 Since that time, there have been numerous reports of this condition in the literature. 2,3 CPM should be distinguished from imbedded hair 4 and pili cuniculati, 5 where exogenous human or animal hairs penetrate the skin like a splinter and remain dormant for a period of time.…”

Unilateral migratory linear plantar erythema

“…Since the first documented case of pilus migrans in 1957, 26 additional reports have been published [1][2][3][4][5][8][9][10][11][12][13][14], with patient age ranging from 15 months to 58 years, and 16 patients, including ours, being male [3,12].…”

Pili migrans

“…[1] Since 1957, 27 cases of cutaneous pili migrans have been described using various terms such as burrowing hair, creeping hair, migrating hair, and embedded hair. [2] Only two cases are reported from India. [3] Various locations such as the ankle, sole, toe, breast, cheek, neck, jaw, abdomen, and leg have been reported.…”