Cutaneous Sarcoidosis

Caplan, Arthur; Rosenbach, Misha; Imadojemu, Sotonye

doi:10.1055/s-0040-1713130

Cited by 60 publications

(73 citation statements)

References 101 publications

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“…According to studies, skin is the second or third most commonly affected organ in sarcoidosis, present in up to one-third of the patients [84]. Cutaneous sarcoidosis lesions are frequently the inaugural signs of the disease and sarcoidosis can remain an isolated dermatological condition in more than 30% of cases [85].…”

Section: Skinmentioning

confidence: 99%

See 1 more Smart Citation

Sarcoidosis: A Clinical Overview from Symptoms to Diagnosis

Sève

Pachéco

Durupt

et al. 2021

Cells

268

144

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Sarcoidosis is a multi-system disease of unknown etiology characterized by the formation of granulomas in various organs. It affects people of all ethnic backgrounds and occurs at any time of life but is more frequent in African Americans and Scandinavians and in adults between 30 and 50 years of age. Sarcoidosis can affect any organ with a frequency varying according to ethnicity, sex and age. Intrathoracic involvement occurs in 90% of patients with symmetrical bilateral hilar adenopathy and/or diffuse lung micronodules, mainly along the lymphatic structures which are the most affected system. Among extrapulmonary manifestations, skin lesions, uveitis, liver or splenic involvement, peripheral and abdominal lymphadenopathy and peripheral arthritis are the most frequent with a prevalence of 25–50%. Finally, cardiac and neurological manifestations which can be the initial manifestation of sarcoidosis, as can be bilateral parotitis, nasosinusal or laryngeal signs, hypercalcemia and renal dysfunction, affect less than 10% of patients. The diagnosis is not standardized but is based on three major criteria: a compatible clinical and/or radiological presentation, the histological evidence of non-necrotizing granulomatous inflammation in one or more tissues and the exclusion of alternative causes of granulomatous disease. Certain clinical features are considered to be highly specific of the disease (e.g., Löfgren’s syndrome, lupus pernio, Heerfordt’s syndrome) and do not require histological confirmation. New diagnostic guidelines were recently published. Specific clinical criteria have been developed for the diagnosis of cardiac, neurological and ocular sarcoidosis. This article focuses on the clinical presentation and the common differentials that need to be considered when appropriate.

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Section: Skinmentioning

confidence: 99%

“…• Most common morphology of the specific cutaneous manifestations of sarcoidosis Erythema nodosum is mostly seen in LS and is associated with transient disease that does not require treatment. Other non-specific cutaneous findings of sarcoidosis include calcinosis cutis, clubbing and prurigo [84].…”

Section: Commonmentioning

confidence: 99%

Sarcoidosis: A Clinical Overview from Symptoms to Diagnosis

Sève

Pachéco

Durupt

et al. 2021

Cells

268

144

View full text Add to dashboard Cite

show abstract

“…According to PubMed published data by Karolyn A. Wanat, 25-30% of sarcoidosis cases had skin manifestations. The highest incidence of cutaneous sarcoidosis occurs in Black American females [ 5 ]. Cutaneous sarcoidosis lesions could occur in any area of the skin but they are more pronounced in previously manipulated areas as in tattoos and scars [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Sarcoidosis of a 53-Year-Old Female: A Case Report

Alghamdi¹,

Mazraani²,

Thabet³

et al. 2021

Cureus

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Sarcoidosis is a systemic disease of an unknown cause that affects multiple organs, most commonly lungs, intrathoracic lymph nodes, eyes, and skin, which accounts between 20% and 25%. However, cutaneous sarcoidosis can present without any systemic involvement in 25% of cases. We present a case of a 53-year-old female patient with cutaneous sarcoidosis with no lung involvement. The patient presented to the family medicine department with non-itchy, tender, erythematous papules occurring at the dorsal part of the hands and the right foot for three months. Skin punch biopsy demonstrated multiple dermal-based nodules consisting of non-necrotizing granulomata. Serum angiotensin-converting enzyme level and a chest radiograph were normal and not consistent with pulmonary sarcoidosis. There are different cutaneous manifestations of cutaneous sarcoidosis and early identification helps in early intervention.

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“…4 This difference is explained by the greater propensity of injected silicone to migrate, making it challenging to fully remove surgically, as compared with the silicone gel in implants. 2,3 Akin to the treatment algorithm for cutaneous sarcoidosis, 5 our results suggest that systemic steroids, hydroxychloroquine, and tetracyclines should be considered as first-line agents for SGs from injectable silicone, followed by tumor necrosis factor-alpha inhibitors for refractory disease. Study limitations include the small sample size and retrospective methodology.…”

mentioning

confidence: 84%