Cutaneous sarcoidosis: a histopathological study

Cardoso, JC; Cravo, Mariana; Reis, José; Tellechea, Óscar

doi:10.1111/j.1468-3083.2009.03153.x

Cited by 47 publications

(83 citation statements)

References 12 publications

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“…121 Biopsies can have variable features, including dense lymphocytes, neutrophils, perineural invasion, caseation, and vasculitis. 8,118,119 Polarization of specimens for foreign material is important, but the presence of foreign material does not exclude the diagnosis of sarcoidosis (Fig. 16).…”

Section: Diagnosis and Work-upmentioning

confidence: 98%

“…Although naked, noncaseating granulomas are highly specific for sarcoidosis, these histopathologic features are not always present and have been estimated to be seen in 71% to 89% of cases. [118][119][120] Necrosis within granulomas is very rare in cutaneous sarcoidosis. Different eosinophilic inclusions, including asteroid bodies, Schumann bodies, and crystalline inclusions, can be seen, but are neither specific nor sensitive for sarcoidosis.…”

Section: Diagnosis and Work-upmentioning

confidence: 99%

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Cutaneous Sarcoidosis

Wanat

Rosenbach

2015

Clinics in Chest Medicine

108

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The skin is the second most common organ affected in sarcoidosis, which can affect patients of all ages and races, with African American women having the highest rates of sarcoidosis in the United States. The cutaneous manifestations are protean and can reflect involvement of sarcoidal granulomas within the lesion or represent reactive non-specific inflammation, as seen with erythema nodosum. Systemic work-up is necessary in any patient with cutaneous involvement of sarcoidal granulomas, and treatment depends on other organ involvement and severity of clinical disease. Skin-directed therapies are first line for mild disease, and immunomodulators or immunosuppressants may be necessary.

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Section: Diagnosis and Work-upmentioning

confidence: 98%

Section: Diagnosis and Work-upmentioning

confidence: 99%

Cutaneous Sarcoidosis

Wanat

Rosenbach

2015

Clinics in Chest Medicine

108

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“…However, it is important to know that the sarcoidal pattern of granuloma formation is also found in various other diseases, including inflammatory, noninfectious and infectious diseases [21,22]. On the other hand, a nonsarcoidal pattern may also be present in sarcoidosis [62,63].…”

Section: Histopathology Of Cutaneous Sarcoidosismentioning

confidence: 99%

Sarcoidosis and molecular mimicry—important etiopathogenetic aspects: current state and future directions

Tchernev

Ananiev

Cardoso

et al. 2012

Wien Klin Wochenschr

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Sarcoidosis is a disease of uncertainty in terms of its cause, presentation, and clinical course. The disease has a worldwide distribution and affects all ages, races, and both sex. Sarcoidosis of the skin may have an extremely heterogeneous clinical presentation, so that the definitions of 'great imitator' and 'clinical chameleon' have long been used. The factors that influence clinical picture and severity of the disease are probably linked to the etiopathogenesis of sarcoidosis, which continues to be shrouded in mystery. The current state of the art on the pathogenesis of sarcoidosis is that it is an immunological response in a genetically susceptible individual to an as-yet undefined antigenic stimulus. How exposure occurs in genetically predisposed patients is not completely clear, but the most likely explanation is that these agents or antigens are either inhaled into the lungs or enter through contact with the skin, as these are the common target organs that are constantly in contact with the environment. An autoimmune etiology of sarcoidosis could possibly occur through a process of molecular mimicry of infectious or other environmental antigens to host antigens. This could lead to a cross-mediated immune response and induction of autoimmune disease. This molecular mimicry may probably be responsible for the heterogeneous clinical presentations of the disease. Several investigations and studies have provided valuable evidence on the etiopathogenesis of sarcoidosis, which may lead to the future development of targeted and innovative treatment strategies. Nevertheless, we are still a long way from unravelling the underlying cause of this mysterious disease.

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“…Патоморфологическую основу при всех формах саркоидоза составляет эпителиодно-клеточная гра-нулема без признаков казеозного некроза [6,9,10]. В дерме или подкожной жировой клетчатке обнару-живают резко очерченные и ограниченные от эпи-дермиса и друг от друга гранулемы, состоящие пре-имущественно из эпителиоидных клеток.…”

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“…Концентрически расположенные пучки коллагено-вых волокон вокруг гранулем нередко разволокне-ны и гомогенизированы, окрашиваются пикрофук-сином в красный цвет и дают слабую ШИК-положительную реакцию. В стадии разрешения от-мечается замещение гранулематозных островков соединительной тканью [9,10].…”

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