Cutaneous squamous cell carcinoma as a complication of discoid lupus erythematosus

Paschos, A; Lehmann, Percy; Hofmann, Silke

doi:10.1111/ddg.13944

Cited by 2 publications

(1 citation statement)

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“…However, a study revealed an identical prevalence of cSCC in individuals with DLE, regardless of their history of immunosuppressive medication use [51]. Additionally, it has been noted that early anti-inflammatory medication can reduce the chance of cSCC developing in DLE, despite the clinical presentation's potential for difficulty [57,58]. In their study, Ju et al [59] presented a clinical case involving an individual of African American descent who exhibited the development of squamous cell carcinoma on a pre-existing discoid plaque of extended duration.…”

Section: Discussionmentioning

confidence: 99%

Discoid lupus erythematosus and cutaneous squamous cell carcinoma

Dec,

Arasiewicz

2024

Forum Dermatologicum

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Discoid lupus erythematosus (DLE) is a chronic autoimmune skin disorder characterized by inflammatory skin lesions. Patients with DLE often exhibit photosensitivity, scarring, and a higher susceptibility to skin cancers. This systematic review aims to comprehensively evaluate the existing literature to better understand the relationship between DLE and cutaneous squamous cell carcinoma (cSCC). A systematic search of major medical databases was conducted to identify relevant studies published between 1978 and 2023. Studies were included if they explored the association between DLE and cSCC and reported epidemiological data, clinical features and outcomes. Evidence shows a correlation between DLE and squamous cell carcinoma. The study aimed to find literature about DLE and squamous cell carcinoma (SCC) and analyse potential risk factors. Healthcare providers should be aware of the increased cancer risk in DLE patients, emphasizing the importance of regular skin examinations and sun protection.

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