Cutaneous Squamous Cell Carcinoma in Faghihi Hospital Patients (Shiraz, Iran) in 2015 - 2016: Epidemiological Study

Abstract

Background: Cutaneous Squamous Cell Carcinoma (cSCC) is an invasive primary cutaneous malignancy and the second common cancer among whites. Objectives: To define the frequency and epidemiologic features of cSCC. Methods: This study was carried out on 311 patients referred to the Department of Dermatology at Faghihi Hospital of Shiraz, Southwest Iran, between 2015 -2016. cSCC was diagnosed by pathologists using the standard criteria. The reports were collected along with general information such as age, sex, location, type, and depth of invasion; then it was analyzed by using the statistical software known as SPSS version 23.0 and Minitab software version 18. Chi-square test was used to evaluate the statistical significance. A P value lower than 0.05 was considered as significant. Results: The age range of patients was 21 -95 years old with an average age of 67.63. The sex ratio (male to female) was 2.87 for the total number of cases. The most common stage was well differentiation 97 (31.2%). The most frequent tumor thickness was between two to four millimeters and the most frequent lesion locations were the nose and then the scalp. Conclusions: The frequency of cSCC increased over the years in regards to patients that were referred to the Faghihi Hospital. This results along with other data which are available from other hospitals and medical centers confirm that the frequency of cSCC is increasing in Iran and plan for management of cSCC is essential, nationally.

Synthesis of some new heterocyclic derivatives from aromatic carbonyl compounds and assessment of their antimicrobial activity

“…Synthesis of 4-(2-oxo-2ureidoethyl)amino)benzoic acid [14]: A suspension of [0.01 mole (2.23 gm) ] of compound [13] in10 mL from absolute ethanol and [0.01 Mole 0.6 gm]from urea, the mixture was refluxed for 14 hrs. The precipitate was recrystallized after been filtered.…”

“…Synthesis of [15]: [0.01 Mole, 2.37 gm] of compound [14] was added to of[ 0.01 mole, 2.75 gm)] 4-phenyl phenacyl bromide then dissolve in 20 mL of ethanol. The mixture was refluxed for 12 hrs then precipitate was filtered and recrystallized from ethanol.…”

“…The biological activity of any compound depends on its molecular structure where most of heterocyclic compounds contain sulfur atom do carry pharmaceutical activity and various medical applications [6][7][8][9][10][11][12]. The therapeutic effects of compounds contain 1,3,4-thiadiazole ring have well been studied for number of pathological states including antibacterial, antimycotic, antituberculer, anti-Parkinson cancer drug, anti-inflammatory and anticonvulsant [13][14][15][16][17][18][19].…”

الخصائص المضادة للأكسدة لبعض قواعد Shciff المركبة الجديدة المشتقة من 1 ، 2 ، 4- حلقة تريازول

“…A series of 1,2,4 derivatives have been patented and extensively employed in agriculture (10) . Many workers have reported of organic compounds containing triazole ring ( 11,12 ) . As well as A. Hussain et al (13) reported many compounds with triazole ring.…”