Cutaneous Tumors as the Initial Presentation of Non‐T, Non‐B, Nonmyeloid CD4+ CD56+ Hematolymphoid Malignancy in an Adolescent Boy

Fass, Jonathan; Tichy, Elizabeth H.; Kraus, Eric W.; Herrick, Jennifer L.; Ehsan, Aamir; Peterson, Joe; Grimwood, Ronald E.

doi:10.1111/j.1525-1470.2005.22104.x

Cited by 9 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority of the patients were older adults 2,6,7,29,30 but the disease may occur in younger adults or in children as also previously reported. 2,7,9,25,[31][32][33][34] Most patients presented with cutaneous lesions at initial examination, 2,6 which spread within a few months to involve general areas of the cutis, and blood, bone marrow, and lymph nodes. 8 Cytopenia, especially thrombocytopenia, was common 2,9,29,30,35 and leukocytosis was also noted in some patients.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological features and prognostic significance of CXCL12 in blastic plasmacytoid dendritic cell neoplasm

Hashikawa¹,

Niino²,

Yasumoto³

et al. 2012

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Clinicopathological features and prognostic significance of CXCL12 in blastic plasmacytoid dendritic cell neoplasm

Hashikawa¹,

Niino²,

Yasumoto³

et al. 2012

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

“… 1 A wide spectrum of clinical presentations have been described, ranging from a single nodule to widespread cutaneous manifestations. Fass et al 10 reported a case in which multiple cutaneous tumors were dispersed on the face, trunk, and extremities. In the largest case series to date by Julia et al, 11 most patients (73%) presented with nodular lesions only, whereas other patients had bruise-like patches (12%) or mixed lesions including macules and nodules (14%).…”

Section: Discussionmentioning

confidence: 99%

Blastic Plasmacytoid Dendritic Cell Neoplasm in the Pediatric Population

Nguyen

Stuart

Skupsky

et al. 2015

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Abstract:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare aggressive hematologic malignancy primarily found in adults, often carrying a poor prognosis. There are only 33 reported pediatric cases of BPDCN in the literature. Although standard treatment is not yet established for children, current literature recommends the use of high-risk acute lymphoblastic leukemia (ALL)–type chemotherapy. Recent studies, however, have explored the benefits of combining chemotherapy with stem-cell transplantation. Here, the authors present 2 cases of pediatric BPDCN treated with different modalities. The first case is a 13-year-old girl who presented with a 3-month history of an initially asymptomatic firm nodule on her left shin. The second case is a 15-year-old boy who presented with a 4-month history of an enlarging subcutaneous nodule on the lower leg. Immunohistochemical staining of both patients was positive for markers consistent with BPDCN. The latter patient received ALL-type therapy alone, whereas the former received ALL-type chemotherapy and stem-cell transplantation. Since initial treatment, both patients remain disease-free. These cases contribute to the limited number of pediatric BPDCN cases, thus helping to advance our knowledge toward an optimal treatment protocol for clinical remission.

show abstract

“…Patients are mostly adults and elderly, although cases in younger individuals, including small children, have been reported [12][13][14][15][17][18][19][20][21]. There is a predominance of males.…”

Section: Clinical Featuresmentioning

confidence: 99%

Blastic Plasmacytoid Dendritic Cell Neoplasm

2014

Skin Lymphoma

View full text Add to dashboard Cite

Blastic plasmacytoid dendritic cell neoplasm is a rare and aggressive hematodermic neoplasia with frequent cutaneous involvement and leukemic dissemination. We report the case of a 76-year-old man with a 2 month history of violaceous nodules and a tumor with stony consistency, located on the head, and mandibular, cervical and supraclavicular lymphadenopathies. Multiple thoracic and abdominal adenopathies were identified on computerized tomography. Flow cytometry analysis of the skin, lymph node and bone marrow biopsies demonstrated the presence of plasmocytoid dendritic cell neoplastic precursor cells (CD4+, CD45+, CD56+ and CD123+ phenotype). After initial clinical and laboratorial complete remission with chemotherapy, the patient died due to relapse of the disease associated with the appearance of a cervical mass with medullary compromise. Keywords: Antigens, CD4; Antigens, CD56; Dendritic cells; Leukemia; Leukemic infiltration Resumo: A neoplasia blástica de células dendríticas plasmocitóides é uma neoplasia hematodérmica rara, agressiva, com frequente envolvimento cutâneo e disseminação leucêmica. Relatamos o caso de um homem de 76 anos com quadro clínico com 2 meses de evolução caracterizado por nódulos e tumor de tonalidade violácea, de consistência pétrea, localizados na cabeça, e linfadenopatias mandibular, cervicais e supraclaviculares. Identificaram-se múltiplas adenopatias torácicas e abdominais em tomografia computorizada. A análise por citometria de fluxo de biópsias cutânea, ganglionar e óssea demonstrou a presença de precursores neoplásicos das células dendríticas plasmocitóides (fenótipo CD4+, CD45+, CD56+ e CD123+). Após remissão clínica e laboratorial completa inicial com quimioterapia, veio a falecer por recaída da doença associada ao aparecimento de massa cervical com compromisso medular.

show abstract

Cutaneous Tumors as the Initial Presentation of Non‐T, Non‐B, Nonmyeloid CD4+ CD56+ Hematolymphoid Malignancy in an Adolescent Boy

Cited by 9 publications

References 8 publications

Clinicopathological features and prognostic significance of CXCL12 in blastic plasmacytoid dendritic cell neoplasm

Clinicopathological features and prognostic significance of CXCL12 in blastic plasmacytoid dendritic cell neoplasm

Blastic Plasmacytoid Dendritic Cell Neoplasm in the Pediatric Population

Blastic Plasmacytoid Dendritic Cell Neoplasm

Contact Info

Product

Resources

About