Cutting Edge: Stromal Cell-Derived Factor-1 Is a Costimulator for CD4+ T Cell Activation

Nanki, Toshihiro; Lipsky, Peter E.

doi:10.4049/jimmunol.164.10.5010

Cited by 181 publications

(166 citation statements)

References 30 publications

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“…B cells from different developmental stages, e.g., developing bone marrow B cells (36), B cells leaving GC structures (33), and medullary plasmablasts leaving lymph nodes (34), have been found to express high levels of surface CXCR4 but were unresponsive to CXCL12. In this regard, there is some evidence that CXCR4 might fulfill additional functions besides chemotaxis, e.g., cell growth, proliferation, and transcriptional activation (11,33,37,38). In accordance, CXCL12 treatment has been found to increase NF-B activity in nuclear extracts from CXCR4-transfected murine pre-B lymphoma cells (37).…”

Section: Discussionmentioning

confidence: 90%

Dysregulation of chemokine receptor expression and function by B cells of patients with primary Sjögren's syndrome

Hansen¹,

Reiter²,

Ziprian³

et al. 2005

Arthritis & Rheumatism

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Objective. To assess whether abnormal chemokine receptor expression and/or abnormal responsiveness to the cognate ligands might underlie some of the disturbances in B cell homeostasis characteristic of primary Sjögren's syndrome (SS).Methods. Chemokine receptor expression by CD27؊ naive and CD27؉ memory B cells from patients with primary SS and healthy control subjects was analyzed using flow cytometry, single-cell reverse transcriptase-polymerase chain reaction (RT-PCR), and migration assays.Results. In contrast to healthy subjects, significantly higher expression of both surface CXCR4 and CXCR4 messenger RNA (mRNA) was seen in peripheral blood B cells from patients with primary SS. These differences were most prominent in CD27؊ naive B cells (P < 0.0006). In addition, significantly higher frequencies of CD27؊ naive B cells from patients with primary SS expressed mRNA for the inhibitory regulator of G protein signaling 13 (P ‫؍‬ 0

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Section: Discussionmentioning

confidence: 90%

Dysregulation of chemokine receptor expression and function by B cells of patients with primary Sjögren's syndrome

Hansen¹,

Reiter²,

Ziprian³

et al. 2005

Arthritis & Rheumatism

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“…It was previously reported that activated T cells express CD154 and ICOS (34,35). We used flow cytometry to analyze CD154 and ICOS expression on peripheral blood and synovial CD4 and CD8 T cells from patients with RA.…”

Section: Expression Of Cxcr6 By Cd4 and Cd8 T Cellsmentioning

confidence: 99%

Pathogenic role of the CXCL16–CXCR6 pathway in rheumatoid arthritis

Nanki¹,

Shimaoka²,

Hayashida³

et al. 2005

Arthritis & Rheumatism

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Objective. Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with massive T cell infiltration into the synovium. The accumulated T cells express type 1 cytokines, such as interferon-␥ (IFN␥) and tumor necrosis factor ␣, and activated markers of inflammation, such as CD154 and inducible costimulator (ICOS). It is thought that chemokines contribute to T cell accumulation in the synovium. In this study, we examined the role of CXCL16 and CXCR6 in T cell migration and stimulation in RA synovium.Methods. Expression of CXCL16 and CXCR6 was analyzed by immunohistochemistry, reverse transcription-polymerase chain reaction, Western blotting, and/or flow cytometry. Migration activity was assessed using a chemotaxis chamber. IFN␥ production was analyzed by enzyme-linked immunosorbent assay. The effect of anti-CXCL16 monoclonal antibody on murine collagen-induced arthritis (CIA) was evaluated.Results. CXCL16 was expressed in RA synovium.

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“…IL-2 will induce the expression of CCR5 on human T cells of the memory phenotype, mediating a positive feedback for CCR5 expression [12]. CXCL12 (SDF-1␣) will also costimulate human CD4 positive T cells, implying that T cell stimulatory activity is exhibited by different chemokines [13]. As for CCR5, membrane-associated lipid rafts are important for CXCL12-CXCR4 binding and signaling [14].…”

Section: Chemokines Are (Co)stimulatory For T Cellsmentioning

confidence: 99%