2017
DOI: 10.16943/ptinsa/2017/49241
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Cutting it Right: Plasticity and Strategy of CRISPR RNA Specific Nucleases

Abstract: The existence of adaptive immunity in prokaryotes came to light with the discovery of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) in association with CRISPR-associated (Cas) proteins. This RNA mediated defence system confers resistance against the invading mobile genetic elements such as phages and plasmids. The CRISPR-Cas system operates by forming a ribonucleoprotein complex that comprises of an invader derived small RNA and Cas protein(s). Herein the small RNA acts as a guide to r… Show more

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Cited by 1 publication
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“…This process generates an infection memory and immunizes the host (2,4,(8)(9)(10)). An A-T-rich leader region present upstream to the repeat-spacer array regulates the transcription of the CRISPR locus, and the subsequent Cas nucleasemediated processing of this inert transcript generates short regulatory mature CRISPR RNA (11)(12)(13)(14). In association with other Cas proteins, the CRISPR RNA forms a surveillance complex that detects the recurring infections by MGE via base complementarity.…”
mentioning
confidence: 99%
“…This process generates an infection memory and immunizes the host (2,4,(8)(9)(10)). An A-T-rich leader region present upstream to the repeat-spacer array regulates the transcription of the CRISPR locus, and the subsequent Cas nucleasemediated processing of this inert transcript generates short regulatory mature CRISPR RNA (11)(12)(13)(14). In association with other Cas proteins, the CRISPR RNA forms a surveillance complex that detects the recurring infections by MGE via base complementarity.…”
mentioning
confidence: 99%