CXCL14 and miR-4484 serves as potential salivary biomarkers for early detection of peri-implantitis

Urvasizoglu, Gelengul; Kilic, Ahsen; Capik, Ozel; Gundogdu, Mustafa; Karatas, Omer Faruk

doi:10.1007/s10266-023-00876-z

Odontology

2023

DOI: 10.1007/s10266-023-00876-z

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CXCL14 and miR-4484 serves as potential salivary biomarkers for early detection of peri-implantitis

Gelengul Urvasizoglu,

Ahsen Kilic,

Ozel Capik

et al.

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2024

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Realizing the clinical utility of saliva for monitoring oral diseases

Ebersole,

Hasturk,

Huber

et al. 2024

Periodontology 2000

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In the era of personalized/precision health care, additional effort is being expended to understand the biology and molecular mechanisms of disease processes. How these mechanisms are affected by individual genetics, environmental exposures, and behavioral choices will encompass an expanding role in the future of optimally preventing and treating diseases. Considering saliva as an important biological fluid for analysis to inform oral disease detection/description continues to expand. This review provides an overview of saliva as a diagnostic fluid and the features of various biomarkers that have been reported. We emphasize the use of salivary biomarkers in periodontitis and transport the reader through extant literature, gaps in knowledge, and a structured approach toward validating and determine the utility of biomarkers in periodontitis. A summation of the findings support the likelihood that a panel of biomarkers including both host molecules and specific microorganisms will be required to most effectively identify risk for early transition to disease, ongoing disease activity, progression, and likelihood of response to standard periodontal therapy. The goals would be to develop predictive algorithms that serve as adjunctive diagnostic tools which provide the clinician and patient important information for making informed clinical decisions.

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Realizing the clinical utility of saliva for monitoring oral diseases

Ebersole,

Hasturk,

Huber

et al. 2024

Periodontology 2000

View full text Add to dashboard Cite

show abstract

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CXCL14 and miR-4484 serves as potential salivary biomarkers for early detection of peri-implantitis

Cited by 1 publication

References 35 publications

Realizing the clinical utility of saliva for monitoring oral diseases

Realizing the clinical utility of saliva for monitoring oral diseases

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