CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners

Dai, Zhijie; Wu, Jun; Chen, Fenghua; Cheng, Quan; Zhang, Mingyu; Wang, Ying; Guo, Yong; Song, Tao

doi:10.3892/or.2016.5155

Cited by 30 publications

(35 citation statements)

References 30 publications

(35 reference statements)

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“…The F-box protein FBXL18 promotes glioma progression by promoting K63-linked ubiquitination of Akt [25]. CXCL5 promotes the proliferation and migration of glioma cells [26]. On the other hand, KIAA0247 has been reported to play a tumor suppressing role in proliferation, angiogenesis, and promoting apoptosis of human glioma [27].…”

Section: Discussionmentioning

confidence: 99%

CMIP Promotes Proliferation and Metastasis in Human Glioma

Wang

2017

BioMed Research International

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Glioma is one of the most common primary malignant brain tumors and the outcomes are generally poor. The intrinsic mechanisms involved in glioma development and progression remain unclear. Further studies are urgent and necessary. In this study, we have proven that CMIP (C-Maf-inducing protein) promotes cell proliferation and metastasis in A172 cells through knockdown of CMIP and in U251 cells through overexpression of CMIP by using MTT assay, cell colony formation assay, cell migration assay, and cell invasion assay. Furthermore, we discovered that CMIP upregulates MDM2, which is involved in the promoting role of CMIP in human glioma cells. For clinical study, 99 glioma tissues and 59 normal tissues were analyzed. CMIP expression was higher in glioma tissues than in normal tissues. In glioma tissues, CMIP is found to correlate positively with tumor grade but no significant correlation is found with patients' age, gender, or Karnofsky performance score (KPS). Moreover, CMIP also correlates with low relapse-free survival (RFS) rate and overall survival (OS) rate in glioma patients. Therefore, CMIP is oncogenic and could be a potential target for human glioma diagnosis and therapy.

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Section: Discussionmentioning

confidence: 99%

CMIP Promotes Proliferation and Metastasis in Human Glioma

Wang

2017

BioMed Research International

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“…C-X-C motif chemokine 5 (CXCL5), is a member of the C-X-C chemokine family, that acts as an important attractant for granulocytic immune cells by binding to its receptor C-X-C Chemokine Receptor Type 2 (CXCR2) [10] . CXCL5 overexpression has been observed in several malignancies, including osteosarcoma, glioma, and lung, bladder, liver, prostate and colorectal cancers [10][11][12][13][14][15][16] , demonstrating its roles in tumor carcinogenesis. Furthermore, CXCL5-CXCR2-dominated cross-talk between cancer cells and macrophages or neutrophils could promote tumor metastases in gastric, hepatocellular and prostate cancers [12,17,18] .…”

Section: Ivyspringmentioning

confidence: 99%

CXCL5 overexpression predicts a poor prognosis in pancreatic ductal adenocarcinoma and is correlated with immune cell infiltration

Liu¹,

Peng²,

Wang³

et al. 2020

J. Cancer

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Background: C-X-C motif chemokine 5 (CXCL5) is an important attractant for immune cell accumulation in tumor tissues. Recent evidence has shown that CXCL5 could promote carcinogenesis and cancer progression in a variety of cancer types. However, the relationships between CXCL5, immune cell infiltration and pancreatic ductal adenocarcinoma (PDAC) remain largely unknown. This study aimed to explore the role and regulative mechanism of CXCL5 in PDAC carcinogenesis. Materials and Methods: The expression of CXCL5 in PDAC was analyzed based on online databases and tissue microarray staining, and Western blotting of CXCL5 in PDAC cell lines and patient samples. The correlation between CXCL5 expression and clinicopathological features, prognosis and immune cell infiltration in tumor tissues was analyzed. Results: High expression of CXCL5 was observed both in PDAC tumor tissue and PDAC cell lines, compared to normal pancreas tissues and normal ductal epithelium cells. High CXCL5 expression in tumor tissues was positively correlated with an advanced T stage (p=0.036), a positive tumor lymph node metastasis (p=0.014), a poor differentiation status (p=0.003) and a poor prognosis (p=0.001). Combination of CA242 and CXCL5 expression (p<0.0001) served as a better prognostic factor than CA242 alone (p=0.006). In addition, PDAC patients with high CXCL5 expression had more intratumoral M2 polarized macrophages (p=0.0248), neutrophils (p=0.0068) and IgG + plasma cells (p=0.0133) than patients with low CXCL5 expression. Conclusions: The expression of CXCL5 is elevated in pancreatic cancer cells. High CXCL5 expression is positively correlated with poor survival and the increased infiltration of several types of immune suppressive cells. Thus, CXCL5 could be a promising therapeutic target for PDAC immunotherapy.

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“…According to the previous studies, more than 14 different malignant tumor types, including breast cancer [15], bladder cancer [16], non-small cell lung cancer [17], gastric cancer [18], head and neck squamous cell carcinoma [19], cholangiocarcinoma [20], hepatocellular carcinoma [21], prostate cancer [22], pancreatic cancer [23], colorectal cancer [24], glioma [25], endometrial cancer [26], nasopharyngeal carcinoma [27], and squamous carcinoma of larynx [6], had high expression of CXCL5 when compared to para-carcinoma or normal tissues (Table 1). By identifying and validating the genes regarding the development of gastric cancer, researchers have found that CXCL5, as one of the substances, was associated with early stages of the disease [28].…”

Section: Overexpression Of Cxcl5 In Tumorsmentioning

confidence: 99%

CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target

Zhang

Wang

Sun

et al. 2020

Cancer Communications

155

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The components of the tumor microenvironment (TME) in solid tumors, especially chemokines, are currently attracting much attention from scientists. C-X-C motif chemokine ligand 5 (CXCL5) is one of the important chemokines in TME. Overexpression of CXCL5 is closely related to the survival time, recurrence and metastasis of cancer patients. In TME, CXCL5 binds to its receptors, such as C-X-C motif chemokine receptor 2 (CXCR2), to participate in the recruitment of immune cells and promote angiogenesis, tumor growth, and metastasis. The CXCL5/CXCR2 axis can act as a bridge between tumor cells and host cells in TME. Blocking the transmission of CXCL5/CXCR2 signals can increase the sensitivity and effectiveness of immunotherapy and slow down tumor progression. CXCL5 and CXCR2 are also regarded as biomarkers for predicting prognosis and molecular targets for customizing the treatment. In this review, we summarized the current literature regarding the biological functions and clinical significance of CXCL5/CXCR2 axis in TME. The possibility to use CXCL5 and CXCR2 as potential prognostic biomarkers and therapeutic targets in cancer is also discussed

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CXCL5 promotes the proliferation and migration of glioma cells in autocrine- and paracrine-dependent manners

Cited by 30 publications

References 30 publications

CMIP Promotes Proliferation and Metastasis in Human Glioma

CMIP Promotes Proliferation and Metastasis in Human Glioma

CXCL5 overexpression predicts a poor prognosis in pancreatic ductal adenocarcinoma and is correlated with immune cell infiltration

CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target

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