CXCR3‐positive B cells found at elevated frequency in the peripheral blood of patients with MALT lymphoma are attracted by MIG and belong to the lymphoma clone

Suefuji, Hiroaki; Ohshima, Koichi; Karube, Kennosuke; Kawano, Riko; Nabeshima, Kazuki; Suzumiya, J; Hayabuchi, Naofumi; Kikuchi, Masahiro

doi:10.1002/ijc.20823

Cited by 33 publications

(37 citation statements)

References 24 publications

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“…Some of these chemokine receptors have already been described in MALT lymphoma and in diffuse large B-cell lymphoma likewise by several authors. 9,11,16,[29][30][31] In our study, CCR9 mRNA expression significantly correlated with the proliferation rate in both lymphoma entities and its protein expression was restricted to malignant B cells with a significantly higher occurrence on extranodal diffuse large B-cell lymphoma cells. Expression of CCR9 was described to be localized on gut-homing B and T cells having a role in mucosal immune response.…”

Section: Discussionmentioning

confidence: 82%

“…2 Further, different patterns of chemokine receptor expression identified in different malignant B-cell subsets suggest that these chemokine receptors are functional and have a crucial role in malignant B-cell circulation leading to the emergence of monoclonal B cells and, eventually to transformation. [8][9][10][11] The development of chemokine antagonists and their use in clinical trials for a variety of diseases shows the potential of chemokine receptors for molecular-targeted therapy. 12 The aim of the present study was to identify expression patterns of 19 chemokine receptors of non-neoplastic stomach specimens, H. pyloriassociated gastritis, gastric MALT lymphomas and of extranodal diffuse large B-cell lymphoma arising from MALT lymphoma (transformed MALT lymphoma) in the stomach.…”

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confidence: 99%

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Chemokine receptors in gastric MALT lymphoma: loss of CXCR4 and upregulation of CXCR7 is associated with progression to diffuse large B-cell lymphoma

et al. 2013

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Chemokine receptors have a crucial role in the development and progression of lymphoid neoplasms. To determine the chemokine receptor expression profile in gastric mucosa-associated lymphoid tissue (MALT) lymphoma, we performed an expression analysis of 19 chemokine receptors at mRNA levels by using real-time RT-PCR, as well as of five chemokine receptors-CCR8, CCR9, CXCR4, CXCR6 and CXCR7-by immunohistochemistry on human tissue samples of Helicobacter pylori-associated gastritis, gastric MALT lymphoma and gastric extranodal diffuse large B-cell lymphoma originating from MALT lymphoma (transformed MALT lymphoma). Following malignant transformation from H. pylori-associated gastritis to MALT lymphoma, an upregulation of CCR7, CXCR3 and CXCR7, and a loss of CXCR4 were detected. The transformation of gastric MALT lymphomas to gastric extranodal diffuse large B-cell lymphoma was accompanied by upregulation of CCR1, CCR5, CCR7, CCR8, CCR9, CXCR3, CXCR6, CXCR7 and XCR1. Remarkably, CXCR4 expression was exclusively found in nodal marginal B-cell lymphomas and nodal diffuse large B-cell lymphomas but not at extranodal manifestation sites, ie, in gastric MALT lymphomas or gastric extranodal diffuse large B-cell lymphomas. Furthermore, the incidence of bone marrow infiltration (16/51 with bone marrow involvement vs 35/51 with bone marrow involvement; Spearman q ¼ 0467 Po0.001) positively correlated with CXCR4 expression. CXCL12, the ligand of CXCR4 and CXCR7, was expressed by epithelial, endothelial and inflammatory cells, MALT lymphoma cells and was most strongly expressed by extranodal diffuse large B-cell lymphoma cells, suggesting at least in part an autocrine signaling pathway. Our data indicate that CXCR4 expression is associated with nodal manifestation and a more advanced stage of lymphomas and hence, might serve as useful clinical prognostic marker.

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Section: Discussionmentioning

confidence: 82%

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confidence: 99%

Chemokine receptors in gastric MALT lymphoma: loss of CXCR4 and upregulation of CXCR7 is associated with progression to diffuse large B-cell lymphoma

et al. 2013

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“…The excess immune stimulation by persistent antigens creates T-cell-driven B-cell hyperplasia, from which a malignant cell undergoes unchecked clonal expansion and gives rise to mucosa-associated lymphoid tissue (MALT) lymphomas (120). Both the T cells recruited to the site of inflammation and the B cells of MALT lymphomas express CXCR3, a receptor for IFN-␥-induced inflammatory chemokines (196,235,253). After some time, MALT lymphomas may progress to a state that then becomes independent of the underlying chronic infection that instigated its initial growth.…”

Section: Antigen-driven Lymphoproliferationmentioning

confidence: 99%

Role of Bacteria in Oncogenesis

2010

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SUMMARY Although scientific knowledge in viral oncology has exploded in the 20th century, the role of bacteria as mediators of oncogenesis has been less well elucidated. Understanding bacterial carcinogenesis has become increasingly important as a possible means of cancer prevention. This review summarizes clinical, epidemiological, and experimental evidence as well as possible mechanisms of bacterial induction of or protection from malignancy.

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“…The expression profiles of chemokine receptors on B-cell proliferative disorders have been studied. 4,5 Among chemokine receptors, CXCR3 has been intensely studied. CXCR3 expression is highly variable on normal B cells and on cells from B-cell lymphoproliferative disorders, possibly because of their lability during processing.…”

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confidence: 99%

Analysis of CXCL9 and CXCR3 expression in a case of intravascular large B-cell lymphoma

Kato

Ohshima

Mizuno

et al. 2009

Journal of the American Academy of Dermatology

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CXCR3‐positive B cells found at elevated frequency in the peripheral blood of patients with MALT lymphoma are attracted by MIG and belong to the lymphoma clone

Cited by 33 publications

References 24 publications

Chemokine receptors in gastric MALT lymphoma: loss of CXCR4 and upregulation of CXCR7 is associated with progression to diffuse large B-cell lymphoma

Chemokine receptors in gastric MALT lymphoma: loss of CXCR4 and upregulation of CXCR7 is associated with progression to diffuse large B-cell lymphoma

Role of Bacteria in Oncogenesis

Analysis of CXCL9 and CXCR3 expression in a case of intravascular large B-cell lymphoma

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