2006
DOI: 10.3892/ijo.28.1.61
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CXCR4 expression is associated with lymph-node metastasis of oral squamous cell carcinoma

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Cited by 53 publications
(75 citation statements)
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“…In this study, we show that CXCR4 silencing leads to a significant decrease of Tca8113 cells migration and invasion and provide evidence that CXCR4 regulates the transcriptional levels of MMP-9 and MMP-13 in Tca8113 cells. We The finding that CXCR4 silencing led to a significant decrease of Tca8113 cells migration and invasion was consistent with many previous reports, which showed that high levels of CXCR4 expression promoted OSCC cell invasion (26). Moreover, functional blocking of CXCR4 by TN14003 also led to decreased cell migration and invasion, which was also consistent with reports that TN14003 treatment decreased migration of breast cancer cells and pancreatic cancer cells in vitro and reduced pulmonary metastasis of breast cancer in SCID mice (30,39).…”
Section: Discussionsupporting
confidence: 81%
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“…In this study, we show that CXCR4 silencing leads to a significant decrease of Tca8113 cells migration and invasion and provide evidence that CXCR4 regulates the transcriptional levels of MMP-9 and MMP-13 in Tca8113 cells. We The finding that CXCR4 silencing led to a significant decrease of Tca8113 cells migration and invasion was consistent with many previous reports, which showed that high levels of CXCR4 expression promoted OSCC cell invasion (26). Moreover, functional blocking of CXCR4 by TN14003 also led to decreased cell migration and invasion, which was also consistent with reports that TN14003 treatment decreased migration of breast cancer cells and pancreatic cancer cells in vitro and reduced pulmonary metastasis of breast cancer in SCID mice (30,39).…”
Section: Discussionsupporting
confidence: 81%
“…Expression of MMPs and other extracellular proteinases have been shown to positively correlate with the progression of cancer in patients (10,42). It is interesting to note that several studies have shown that the expression levels of CXCR4 were also highly upregulated in human head and neck squamous cell carcinoma and OSCC, suggesting that MMPs and CXCR4 expression levels are likely coupled (26,43,44). However, it is unknown how these genes regulate each other during tumorigenesis.…”
Section: Discussionmentioning
confidence: 99%
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“…Tissues to which tumor cells selectively metastasize, such as the lymph nodes, bone, lungs, and liver, are often the most abundant source of SDF-1α (Muller et al, 2001). A significant association between CXCR4 expression and lymph node metastasis has been reported in OSCC Uchida et al, 2004;Ishikawa et al, 2006). However, the molecular mechanisms associated with CXCR4-mediated OSCC metastasis remains poorly understood.…”
Section: Introductionmentioning
confidence: 99%
“…Chemokines have previously been reported to play an important role in both tumor growth and in establishing organ-specific metastases in several malignancies (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). The expression of CXCR4 in gastric cancer correlates with peritoneal dissemination (9) and cancerous CXCL12 expression was an independent prognostic factor in gastric cancer (10) and the expression of CCR6 in colorectal cancer is associated with synchronous liver metastases (11).…”
Section: Introductionmentioning
confidence: 99%