Cyanoacrylate Adhesive

deGuillebon, Henri

doi:10.1001/archopht.1972.01000020409009

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…DeGuillebon et al ( 1971 ) reported 0.77–1.41 mN in the equator compared to 0.86–1.206 mN in the posterior pole in rabbits. One exception to this is a study by DeGuillebon et al ( 1972 ) that found increasing peel rates increased RPE adhesion in the posterior pole compared to the equator. The rates used in the present study are quasistatic, and suitable for PVD investigations.…”

Section: Discussionmentioning

confidence: 95%

“…Several studies have quantitatively measured adhesion between the neurosensory layer and retina pigment epithelium (RPE) (Zauberman and Berman, 1969 ; Lincoff et al, 1970 ; DeGuillebon et al, 1971 , 1972 ; DeGuillebon and Zauberman, 1972 ; Zauberman, 1972 ; Zauberman and DeGuillebon, 1972 ; Zauberman et al, 1972 ; Owczarek et al, 1975 ; Kain, 1984 ). Similar to our results, these studies report significantly greater adhesion in the equator compared to the posterior pole.…”

Section: Discussionmentioning

confidence: 99%

“…The adhesive forces between the RPE and choroid were higher in the equator compared to the posterior region (Zauberman and Berman, 1969 ), and this regional dependence was reported to be greater in younger rabbits (1–2 months old) compared to adult rabbits (DeGuillebon et al, 1971 ). Additional experiments report significantly increased RPE adhesion with peel rate (DeGuillebon et al, 1972 ) and significantly decreased adhesion with post-mortem time (Zauberman and DeGuillebon, 1972 ). A subsequent study by Endo et al ( 1988 ), however, reported that refrigeration of enucleated eyes delayed deterioration up to at least 18 h.…”

Section: Introductionmentioning

confidence: 96%

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Changes in Vitreoretinal Adhesion With Age and Region in Human and Sheep Eyes

Creveling

Colter

Coats

2018

Front. Bioeng. Biotechnol.

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While several studies have qualitatively investigated age- and region-dependent adhesion between the vitreous and retina, no studies have directly measured the vitreoretinal strength of adhesion. In this study, we developed a rotational peel device and associated methodology to measure the maximum and steady-state peel forces between the vitreous and the retina. Vitreoretinal adhesion in the equator and posterior pole were measured in human eyes from donors ranging 30 to 79 years of age, and in sheep eyes from premature, neonatal, young lamb, and young adult sheep. In human eyes, maximum peel force in the equator (7.24 ± 4.13 mN) was greater than in the posterior pole (4.08 ± 2.03 mN). This trend was especially evident for younger eyes from donors 30 to 39 years of age. After 60 years of age, there was a significant decrease in the maximum equatorial (4.69 ± 2.52 mN, p = 0.016) and posterior pole adhesion (2.95 ± 1.25 mN, p = 0.037). In immature sheep eyes, maximum adhesion was 7.60 ± 3.06 mN, and did not significantly differ between the equator and posterior pole until young adulthood. At this age, the maximum adhesion in the equator nearly doubled (16.67 ± 7.45 mN) that of the posterior pole, similar to the young adult human eyes. Light microscopy images suggest more disruption of the inner limiting membrane (ILM) in immature sheep eyes compared to adult sheep eyes. Interestingly, in human eyes, ILM disruption was significantly greater in the posterior pole (p < 0.05) and in people over 60 years of age (p < 0.02). These findings supplement the current discussion surrounding age-related posterior vitreous detachment, and the risk factors and physiological progressions associated with this condition. In addition, these data further our understanding of the biomechanical mechanisms of vitreoretinal adhesion, and can be used to develop age- appropriate computational models simulating retinal detachment, hemorrhaging, or retinal trauma.

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Section: Discussionmentioning

confidence: 95%