Cyanoacrylate Dermal Closure in Spine Surgery: Systematic Review and Pooled Analysis

Tan, Terence; Rutges, J.P.H.J.; Marion, Travis; Hunn, Martin; Tee, Jin

doi:10.1177/2192568219861619

Cited by 8 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Modern skin glue, mainly composed of glue, has the ability to provide the wound with a mechanical barrier as well as bactericidal properties against gram-positive bacteria [ 15 ]. In a recent systematic review from Tan et al [ 16 ], cyanoacrylate dermal closure was associated with significantly low rates of SSIs following both lumbar microdiscectomy and laminectomy (0.4% and 1.8%, respectively). However, included studies were mainly composed of case series, thus substantially impacting the reliability of data.…”

Section: Discussionmentioning

confidence: 99%

Surgeon Preference Regarding Wound Dressing Management in Lumbar Fusion Surgery: An AO Spine Global Cross-Sectional Study

Ambrosio,

Vadalà,

Tavakoli

et al. 2024

Neurospine

View full text Add to dashboard Cite

Objective: To evaluate the global practice pattern of wound dressing use after lumbar fusion for degenerative conditions.Methods: A survey issued by AO Spine Knowledge Forums Deformity and Degenerative was sent out to AO Spine members. The type of postoperative dressing employed, timing of initial dressing removal, and type of subsequent dressing applied were investigated. Differences in the type of surgery and regional distribution of surgeons’ preferences were analyzed.Results: Right following surgery, 60.6% utilized a dry dressing, 23.2% a plastic occlusive dressing, 5.7% glue, 6% a combination of glue and polyester mesh, 2.6% a wound vacuum, and 1.2% other dressings. The initial dressing was removed on postoperative day 1 (11.6%), 2 (39.2%), 3 (20.3%), 4 (1.7%), 5 (4.3%), 6 (0.4%), 7 or later (12.5%), or depending on drain removal (9.9%). Following initial dressing removal, 75.9% applied a dry dressing, 17.7% a plastic occlusive dressing, and 1.3% glue, while 12.1% used no dressing. The use of no additional coverage after initial dressing removal was significantly associated with a later dressing change (p < 0.001). Significant differences emerged after comparing dressing management among different AO Spine regions (p < 0.001).Conclusion: Most spine surgeons utilized a dry or plastic occlusive dressing initially applied after surgery. The first dressing was more frequently changed during the first 3 postoperative days and replaced with the same type of dressing. While dressing policies tended not to vary according to the type of surgery, regional differences suggest that actual practice may be based on personal experience rather than available evidence.

show abstract

Section: Discussionmentioning

confidence: 99%

Surgeon Preference Regarding Wound Dressing Management in Lumbar Fusion Surgery: An AO Spine Global Cross-Sectional Study

Ambrosio,

Vadalà,

Tavakoli

et al. 2024

Neurospine

View full text Add to dashboard Cite

show abstract

“…Tan et al [ 25 ] used cyanoacrylate to close the dermal and subcutaneous layers in spinal surgeries. Wound dehiscence and surgical site infection occurred in a small number of patients.…”

Section: Discussionmentioning

confidence: 99%

Effects of Cyanoacrylate in Rabbits with Induced Achilles Tendon Rupture

et al. 2021

View full text Add to dashboard Cite

Background In this study, we aimed to investigate the effects of N-butyl-2-cyanoacrylate (cyanoacrylate) on the biomechanical and histopathological aspects of tendon healing in a rabbit model of Achilles tendon injury. Material/Methods In total, 36 rabbits were randomized to experimental (cyanoacrylate) and control groups (n=36 tendons in each group). A simple suture was used in the control group and a simple suture plus cyanoacrylate was used in the experimental group. Nine rabbits from each group were euthanized at week 4 and week 6 after surgery for histopathological and biomechanical testing. Results Granulation tissue formation was significantly greater in the experimental group in week 4 and week 6 than in the control group. Foreign body giant cell formation was significantly higher in the experimental group in week 4 and week 6. The maximum rupture force was significantly higher in the experimental group in week 4 and week 6 than in the control group. Elasticity and stiffness were comparable between groups in week 4; however, stiffness, but not elasticity, was significantly higher in the experimental group in week 6. Conclusions In the short term, cyanoacrylate enhanced tendon endurance in both a histopathological and biomechanical manner. We conclude that the early initiation of rehabilitation in patients may be safe in cases of cyanoacrylate use for surgical repair of tendon injury.

show abstract

“…Previous studies investigating the efficacy of Dermabond compared with that of standard staples and sutures in adult surgery revealed equivalence in cosmetic outcomes and total cost of closure technique. [1][2][3] Current literature regarding the use of Dermabond in children has focused on the effectiveness of the adhesive for laceration repair in the emergency department, 4,5 as well as primary closure of incisions in plastic and general surgery. Little has been written regarding Dermabond in pediatric orthopedics.…”

mentioning

confidence: 99%

“…Dermabond (Dermabond; Ethicon, Sommerville, NJ), a formulation of 2-octyl cyanoacrylate, is a topical skin adhesive used to close surgical incisions and traumatic lacerations. Previous studies investigating the efficacy of Dermabond compared with that of standard staples and sutures in adult surgery revealed equivalence in cosmetic outcomes and total cost of closure technique 1–3 . Current literature regarding the use of Dermabond in children has focused on the effectiveness of the adhesive for laceration repair in the emergency department, 4,5 as well as primary closure of incisions in plastic and general surgery.…”

mentioning

confidence: 99%

Incidence of Skin Sensitivity Following Dermabond Application in Pediatric Orthopedic Surgery

Koritz,

Canizares,

Cook

et al. 2023

Journal of Pediatric Orthopaedics

View full text Add to dashboard Cite

Background: Dermabond (Dermabond; Ethicon, Sommerville, NJ), is a skin adhesive commonly utilized in pediatric orthopedic surgery for postoperative wound care. Few studies have examined outcomes of Dermabond exposure in children. The purpose of this study is to estimate the incidence of skin reactions following Dermabond exposure in pediatric orthopedic surgery and investigate potential risk factors associated with Dermabond sensitivity. Methods: This was a retrospective study of a level-one pediatric trauma center. All orthopaedic surgeries in 2019 were screened for Dermabond application. Three surgeons with the highest rates of Dermabond application defined our cohort. Out of 2990 surgeries in 2019, the 3 surgeons performed 234 surgeries with Dermabond. Postoperative reactions and repeat Dermabond exposures were collected for these 234 patients. Subjects with known allergies to Dermabond were excluded. Reactions were defined. as discoloration, irritation, and wound dehiscence. Significant differences between patients with repeat Dermabond exposures and those without were determined using χ2 analysis. Associations between patient characteristics and sensitivity were determined using logistic regression analysis. P values less than 0.05 were considered significant. Results: In all, 234 patients were included for analysis. The mean age at surgery was 12.5 years (SD 6.1), and 39% (92/234) of the cohort was male. Thirty-two patients (14%) experienced skin reactions during the study period (95% CI=7%–19%). Reactions most frequently included. erythema (10/32; 31%) and itchiness (10/32; 31%). Reactions were most frequently treated with oral antibiotics, Benadryl, or a dressing change. Of 144 patients with 1 Dermabond exposure, 17 (12%) experienced reactions (95% CI=7%–18%). Of 128 patients experiencing a repeat Dermabond exposure, 27 (21%) experienced reactions (95% CI=19%–34%, P=0.03). Age, surgical procedure, and surgical location were not, associated with a variable rate of sensitivity. Conclusions: Sensitivity to Dermabond after pediatric orthopedic surgery occurred at a higher rate than seen in adults, and patients with multiple Dermabond exposures experienced significantly higher sensitivity than patients with a single exposure. Increased awareness of this potential complication is needed to help inform decisions regarding Dermabond’s application in pediatric orthopedics.

show abstract

Cyanoacrylate Dermal Closure in Spine Surgery: Systematic Review and Pooled Analysis

Cited by 8 publications

References 19 publications

Surgeon Preference Regarding Wound Dressing Management in Lumbar Fusion Surgery: An AO Spine Global Cross-Sectional Study

Surgeon Preference Regarding Wound Dressing Management in Lumbar Fusion Surgery: An AO Spine Global Cross-Sectional Study

Effects of Cyanoacrylate in Rabbits with Induced Achilles Tendon Rupture

Incidence of Skin Sensitivity Following Dermabond Application in Pediatric Orthopedic Surgery

Contact Info

Product

Resources

About