Cyanobacteria and microalgae bioactive compounds in skin-ageing: potential to restore extracellular matrix filling and overcome hyperpigmentation

Favas, Rita; Morone, Janaína; Martíns, Rosário; Vasconcelos, Vı́tor; Lopes, Graciliana

doi:10.1080/14756366.2021.1960830

Cited by 37 publications

(23 citation statements)

References 94 publications

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“…However, the importance of the skin goes much further, encompassing an undeniable socio-cultural role. In fact, skin appearance and shape are of crucial importance to an individual’s self-esteem, its care and beautification being part of the daily routine since ancient times [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

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Cyanobacteria Secondary Metabolites as Biotechnological Ingredients in Natural Anti-Aging Cosmetics: Potential to Overcome Hyperpigmentation, Loss of Skin Density and UV Radiation-Deleterious Effects

et al. 2022

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The loss of density and elasticity, the appearance of wrinkles and hyperpigmentation are among the first noticeable signs of skin aging. Beyond UV radiation and oxidative stress, matrix metalloproteinases (MMPs) assume a preponderant role in the process, since their deregulation results in the degradation of most extracellular matrix components. In this survey, four cyanobacteria strains were explored for their capacity to produce secondary metabolites with biotechnological potential for use in anti-aging formulations. Leptolyngbya boryana LEGE 15486 and Cephalothrix lacustris LEGE 15493 from freshwater ecosystems, and Leptolyngbya cf. ectocarpi LEGE 11479 and Nodosilinea nodulosa LEGE 06104 from marine habitats were sequentially extracted with acetone and water, and extracts were analyzed for their toxicity in cell lines with key roles in the skin context (HaCAT, 3T3L1, and hCMEC). The non-toxic extracts were chemically characterized in terms of proteins, carotenoids, phenols, and chlorophyll a, and their anti-aging potential was explored through their ability to scavenge the physiological free radical superoxide anion radical (O2•−), to reduce the activity of the MMPs elastase and hyaluronidase, to inhibit tyrosinase and thus avoid melanin production, and to block UV-B radiation (sun protection factor, SPF). Leptolyngbya species stood out for anti-aging purposes: L. boryana LEGE 15486 presented a remarkable SPF of 19 (at 200 µg/mL), being among the best species regarding O2•− scavenging, (IC50 = 99.50 µg/mL) and also being able to inhibit tyrosinase (IC25 = 784 µg/mL), proving to be promising against UV-induced skin-aging; L. ectocarpi LEGE 11479 was more efficient in inhibiting MMPs (hyaluronidase, IC50 = 863 µg/mL; elastase, IC50 = 391 µg/mL), thus being the choice to retard dermal density loss. Principal component analysis (PCA) of the data allowed the grouping of extracts into three groups, according to their chemical composition; the correlation of carotenoids and chlorophyll a with MMPs activity (p < 0.01), O2•− scavenging with phenolic compounds (p < 0.01), and phycocyanin and allophycocyanin with SPF, pointing to these compounds in particular as responsible for UV-B blockage. This original survey explores, for the first time, the biotechnological potential of these cyanobacteria strains in the field of skin aging, demonstrating the promising, innovative, and multifactorial nature of these microorganisms.

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Section: Introductionmentioning

confidence: 99%

“…Inhibitory concentration (IC) values (µg dry extract /mL) of cyanobacteria extracts obtained for superoxide anion radical scavenging1 . Values are expressed as the mean ± SD of three determinations.…”

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confidence: 99%

Cyanobacteria Secondary Metabolites as Biotechnological Ingredients in Natural Anti-Aging Cosmetics: Potential to Overcome Hyperpigmentation, Loss of Skin Density and UV Radiation-Deleterious Effects

et al. 2022

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“…As examples, cyanobacteria are source of exopolysaccharides with exceptional properties as food additives, biostimulants and soil conditioners in agriculture, biopolymers, bioadhesives, bioflocculants [49][50][51], anti-viral, mycosporine-like amino acid, and scytonemin [14,52]. Other valuable compounds are carotenoids, phycobiliproteins, and polyphenols which are used in cosmetic and cosmeceutical industries as sun blockers and anti-ageing for preventing the formation of wrinkles and skin sagging [38,53,54]. In the therapeutic and pharmaceutical application, the chemical and biological diversity of cyanobacteria make them an extraordinary resource for the discovery of new drugs.…”

Section: General Usesmentioning

confidence: 99%

“…Cyanobacteria are often called "sustainable biofactories" for their sunlight-driven conversion of CO 2 into a renewable resource of high-value industrial products [37]. It is known that cyanobacteria synthesis pigments, lipids proteins, polysaccharides, and other compounds with proven bioactivity [38,39]. In addition to that, cyanobacteria have the ability to perform different ways of metabolism and the capacity to quickly switch from one to another as survival mechanisms of adaptation to extreme irradiation, temperature, pH, or salinity conditions generating a wide range of biologically active secondary metabolites [40][41][42][43][44].…”

Section: General Usesmentioning

confidence: 99%

Cyanobacteria: A Natural Source for Controlling Agricultural Plant Diseases Caused by Fungi and Oomycetes and Improving Plant Growth

et al. 2022

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Cyanobacteria, also called blue-green algae, are a group of prokaryotic microorganisms largely distributed in both terrestrial and aquatic environments. They produce a wide range of bioactive compounds that are mostly used in cosmetics, animal feed and human food, nutraceutical and pharmaceutical industries, and the production of biofuels. Nowadays, the research concerning the use of cyanobacteria in agriculture has pointed out their potential as biofertilizers and as a source of bioactive compounds, such as phycobiliproteins, for plant pathogen control and as inducers of plant systemic resistance. The use of alternative products in place of synthetic ones for plant disease control is also encouraged by European Directive 2009/128/EC. The present up-to-date review gives an overall view of the recent results on the use of cyanobacteria for both their bioprotective effect against fungal and oomycete phytopathogens and their plant biostimulant properties. We highlight the need for considering several factors for a proper and sustainable management of agricultural crops, ranging from the mechanisms by which cyanobacteria reduce plant diseases and modulate plant resistance to the enhancement of plant growth.

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“…β-carotene has been recognized by the FDA, the European Community, Japan, the WHO, and other international organizations and experts as a precursor of VA, a food additive, and a nutritional supplement [ 105 ]. Naturally derived β-carotene has high biological activity, which can be used in eye diseases, anti-oxidation, anti-aging, cancer prevention, pigmentation in animals, and the enhancement of the animal reproducibility and immune functions [ 102 , 106 , 107 ]. Streptozotocin-induced diabetic rats have been treated with Dunaliella salina extract prepared through pressurized liquid extraction for up to 3 days [ 108 ].…”

Section: Studies Of Bioactivities Of β-Carotene In Microalgaementioning

confidence: 99%

The Extraction of β-Carotene from Microalgae for Testing Their Health Benefits

Jing

Chen

et al. 2022

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β-carotene, a member of the carotenoid family, is a provitamin A, and can be converted into vitamin A (retinol), which plays essential roles in the regulation of physiological functions in animal bodies. Microalgae synthesize a variety of carotenoids including β-carotene and are a rich source of natural β-carotene. This has attracted the attention of researchers in academia and the biotech industry. Methods to enrich or purify β-carotene from microalgae have been investigated, and experiments to understand the biological functions of microalgae products containing β-carotene have been conducted. To better understand the use of microalgae to produce β-carotene and other carotenoids, we have searched PubMed in August 2021 for the recent studies that are focused on microalgae carotenoid content, the extraction methods to produce β-carotene from microalgae, and the bioactivities of β-carotene from microalgae. Articles published in peer-reviewed scientific journals were identified, screened, and summarized here. So far, various types and amounts of carotenoids have been identified and extracted in different types of microalgae. Diverse methods have been developed overtime to extract β-carotene efficiently and practically from microalgae for mass production. It appears that methods have been developed to simplify the steps and extract β-carotene directly and efficiently. Multiple studies have shown that extracts or whole organism of microalgae containing β-carotene have activities to promote lifespan in lab animals and reduce oxidative stress in culture cells, etc. Nevertheless, more studies are warranted to study the health benefits and functional mechanisms of β-carotene in these microalgae extracts, which may benefit human and animal health in the future.

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Cyanobacteria and microalgae bioactive compounds in skin-ageing: potential to restore extracellular matrix filling and overcome hyperpigmentation

Cited by 37 publications

References 94 publications

Cyanobacteria Secondary Metabolites as Biotechnological Ingredients in Natural Anti-Aging Cosmetics: Potential to Overcome Hyperpigmentation, Loss of Skin Density and UV Radiation-Deleterious Effects

Cyanobacteria Secondary Metabolites as Biotechnological Ingredients in Natural Anti-Aging Cosmetics: Potential to Overcome Hyperpigmentation, Loss of Skin Density and UV Radiation-Deleterious Effects

Cyanobacteria: A Natural Source for Controlling Agricultural Plant Diseases Caused by Fungi and Oomycetes and Improving Plant Growth

The Extraction of β-Carotene from Microalgae for Testing Their Health Benefits

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