Cyanogen: A Versatile Reagent for Diversity-Oriented Synthesis

Abstract

This short review summarises the synthetic applications of cyanogen. The review is divided into several parts, including transitionmetal-catalysed reactions, addition reactions, and cyclisation processes. 1 Introduction 2 Addition Reactions 3 Ring-Closure Reactions 4 Transition-Metal-Catalysed Reactions 5 Conclusions

Synthesis of the first 4-oxobutane-1,1,2,2-tetracarbonitriles containing a phenol fragment and their transformation into cyano-substituted pyrrol-2-ones showing three-position molecular switching

“…The substrates used in the DOS strategy are quite diverse. [11][12][13][14][15][16][17][18][19][20][21][22][23] For example, among them aminoazoles, 12 carbohydrates, 13 isatin derivatives, 14 aminoacetophenones, 15 enynes, 16 malononitrile dimer 17 and a number of other structures [18][19][20][21][22][23] can be highlighted.…”