Cyasterone accelerates fracture healing by promoting MSCs migration and osteogenesis

Zhu, J.-Y.; Chen, Chen; Chen, Hongtai; Huang, Jian; Zhao, Ke; Chen, Dongfeng; Xu, Zhiming; Li, Wangyang; Zhang, Xunchao; Xiong, Yunpu; Xu, Liangliang; Wang, Bin

doi:10.1016/j.jot.2020.11.004

Cited by 22 publications

(15 citation statements)

References 35 publications

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“…Bone maintains dynamic balance coordinated by osteoclast-mediated bone resorption and osteoblast-mediated bone formation ( 4 ). Fluctuations in estrogen levels in postmenopausal women lead to excessive activation of osteoclasts, and the bone formation ability by mesenchymal stem cells (MSCs) and osteoblasts gradually decreases with aging ( 5 ). The second stage of fracture healing includes the recruitment of MSCs, cartilage callus formation, hard callus formation, and bone remodeling ( 6 ).…”

Section: Difficulties In Diagnosis and Treatment Of Osteoporotic Frac...mentioning

confidence: 99%

The “Three in One” Bone Repair Strategy for Osteoporotic Fractures

Chen¹,

Yan²,

Zhang³

et al. 2022

Front. Endocrinol.

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In aging society, osteoporotic fractures have become one major social problem threatening the health of the elderly population in China. Compared with conventional fractures, low bone mass, bone defect and retarded healing issues of osteoporotic fractures lead to great difficulties in treatment and rehabilitation. Addressing major concerns in clinical settings, we proposed the “three in one” bone repair strategy focusing on anti-osteoporosis therapies, appropriate bone grafting and fracture healing accelerating. We summarize misconceptions and repair strategies for osteoporotic fracture management, expecting improvement of prognosis and clinical outcomes for osteoporotic fractures, to further improve therapeutic effect and living quality of patients.

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Section: Difficulties In Diagnosis and Treatment Of Osteoporotic Frac...mentioning

confidence: 99%

The “Three in One” Bone Repair Strategy for Osteoporotic Fractures

Chen¹,

Yan²,

Zhang³

et al. 2022

Front. Endocrinol.

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“…Thus, recruiting MSCs from surrounding tissues or circulation to the fracture callus is very important for bone repair and regeneration (Herrmann et al, 2015;Zhou et al, 2017). In a recent study, Zhu et al investigated the effect of cyasterone (exact from Radix cyathulae) on MSCs migration and osteogenic differentiation in vitro, as well as its role in the healing of rat fractures (Zhu et al, 2021). As the results showed, cyasterone could promote the migration and osteogenesis capacities of MSCs.…”

Section: Othersmentioning

confidence: 99%

“…For example, the 2015 Nobel Prize was awarded for discovering an antimalarial medicine extracted from TCM. With the improved understanding of the underlying mechanism, TCM is becoming increasingly popular in musculoskeletal tissue regeneration (Putnam et al, 2007;Liu et al, 2017;Song et al, 2018b;Zhu et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Bioactive Herbal Extracts of Traditional Chinese Medicine Applied with the Biomaterials: For the Current Applications and Advances in the Musculoskeletal System

et al. 2021

Front. Pharmacol.

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Traditional Chinese medicine (TCM) has demonstrated superior therapeutic effect for musculoskeletal diseases for thousands of years. Recently, the herbal extracts of TCM have received rapid advances in musculoskeletal tissue engineering (MTE). A literature review collecting both English and Chinese references on bioactive herbal extracts of TCM in biomaterial-based approaches was performed. This review provides an up-to-date overview of application of TCMs in the field of MTE, involving regulation of multiple signaling pathways in osteogenesis, angiogenesis, anti-inflammation, and chondrogenesis. Meanwhile, we highlight the potential advantages of TCM, opening the possibility of its extensive application in MTE. Overall, the superiority of traditional Chinese medicine turns it into an attractive candidate for coupling with advanced additive manufacturing technology.

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“…[ 2 ] The prolonged healing period results in higher morbidity, disability, and even mortality, especially in elder patients. [ 3 ] Various strategies aiming at enhancing either osteogenesis or angiogenesis have been developed to rescue the impaired osteoporotic fracture healing, [ 4 , 5 , 6 ] while the outcome remains unsatisfactory. [ 3 , 7 , 8 ]…”

Section: Introductionmentioning

confidence: 99%

Implantable Electrical Stimulation at Dorsal Root Ganglions Accelerates Osteoporotic Fracture Healing via Calcitonin Gene‐Related Peptide

Yao

et al. 2021

Advanced Science

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The neuronal engagement of the peripheral nerve system plays a crucial role in regulating fracture healing, but how to modulate the neuronal activity to enhance fracture healing remains unexploited. Here it is shown that electrical stimulation (ES) directly promotes the biosynthesis and release of calcitonin gene-related peptide (CGRP) by activating Ca 2+ /CaMKII/CREB signaling pathway and action potential, respectively. To accelerate rat femoral osteoporotic fracture healing which presents with decline of CGRP, soft electrodes are engineered and they are implanted at L3 and L4 dorsal root ganglions (DRGs). ES delivered at DRGs for the first two weeks after fracture increases CGRP expression in both DRGs and fracture callus. It is also identified that CGRP is indispensable for type-H vessel formation, a biological event coupling angiogenesis and osteogenesis, contributing to ES-enhanced osteoporotic fracture healing. This proof-of-concept study shows for the first time that ES at lumbar DRGs can effectively promote femoral fracture healing, offering an innovative strategy using bioelectronic device to enhance bone regeneration.

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Cyasterone accelerates fracture healing by promoting MSCs migration and osteogenesis

Cited by 22 publications

References 35 publications

The “Three in One” Bone Repair Strategy for Osteoporotic Fractures

The “Three in One” Bone Repair Strategy for Osteoporotic Fractures

Bioactive Herbal Extracts of Traditional Chinese Medicine Applied with the Biomaterials: For the Current Applications and Advances in the Musculoskeletal System

Implantable Electrical Stimulation at Dorsal Root Ganglions Accelerates Osteoporotic Fracture Healing via Calcitonin Gene‐Related Peptide

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