Cyberlindnera jadinii (teleomorph Candida utilis) candidaemia in a patient with aplastic anaemia: a case report

Treguier, Pauline; David, M; Gargala, Gilles; Camus, Vincent; Stamatoullas, Aspasia; Ménard, Anne‐Lise; Lenain, Pascal; Contentin, Nathalie; Lemasle, Emilie; Lanic, Hélène; Tilly, Hervé; Jardin, Fabrice; Leprêtre, Stéphane

doi:10.1099/jmmcr.0.005160

Cited by 10 publications

(6 citation statements)

References 8 publications

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“…Sequencing of the Internal Transcribed Spacer region also confirmed the diagnosis as Cyberlindera jadinii, the teleomorphic stage of Candida utili s (). Antifungal susceptibility of all isolates revealed wild-type isolates, according to the reported epidemiology cut-off values and as previously described, the MICs of all drugs tested here, with the exception of fluconazole (), demonstrated MIC values corresponding to the least drug concentration tested, which is similar to previous data [5, 9]. A concomitant infection of Candida tropicalis was observed in one patient and CONS in another.…”

Section: Discussionsupporting

confidence: 90%

Candida utilis: a rare cause of septicemia in children

Sreelekshmi

Ninan

Premanand

et al. 2021

Access Microbiology

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Candida utilis is an emerging fungal pathogen in blood. The main aim of this study was to describe the prevalence, methods of speciation and antifungal susceptibility of Candida utilis at a tertiary care centre. Methods. This was a retrospective study carried out at a tertiary care centre in South India. Over a period of 1 year, three Candida utilis were isolated from blood culture identified by MALDI–TOF MS Version 3.2 and were confirmed by ITS sequencing. Susceptibility testing was carried out by micro broth dilution. Results. All three patients had a common risk factor of prolonged ICU stay but the source of infection could not be identified. Candida utilis isolates were identified by MALDI–TOF and confirmed by ITS sequencing. They were pansusceptible to all tested antifungal drugs. Among these, two patients who were treated in hospital had good clinical outcome and response to antifungal drugs. A third patient was lost to follow up. Conclusion. Candida utilis was predominantly seen between 0–3 month olds. Conventional methods of speciation were unable to identify C. utilis to species level. Rapid identification was done by MALDI–TOF MS and confirmed by sequencing. Rapid identification leads to prompt treatment and favours a good clinical outcome.

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Section: Discussionsupporting

confidence: 90%

Candida utilis: a rare cause of septicemia in children

Sreelekshmi

Ninan

Premanand

et al. 2021

Access Microbiology

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“…The species has now been assigned within the Wickerhamomycetaceae clade ( Kidd et al., 2023 ). Within this clade, there are several other species that have been reported to cause human infections, such as Wickerhamomyces anomalus and Cyberlindnera jadinii ( Treguier et al., 2018 ; Zhang et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

A pseudo-outbreak of Cyberlindnera fabianii funguria: Implication from whole genome sequencing assay

Fan

Dai

Kudinha

et al. 2023

Front. Cell. Infect. Microbiol.

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BackgroundAlthough the yeast Cyberlindnera fabianii (C. fabianii) has been rarely reported in human infections, nosocomial outbreaks caused by this organism have been documented. Here we report a pseudo-outbreak of C. fabianii in a urology department of a Chinese hospital over a two-week period.MethodsThree patients were admitted to the urology department of a tertiary teaching hospital in Beijing, China, from Nov to Dec 2018, for different medical intervention demands. During the period Nov 28 to Dec 5, funguria occurred in these three patients, and two of them had positive urine cultures multiple times. Sequencing of rDNA internal transcribed spacer (ITS) region and MALDI-TOF MS were applied for strain identification. Further, sequencing of rDNA non-transcribed spacer (NTS) region and whole genome sequencing approaches were used for outbreak investigation purpose.ResultsAll the cultured yeast strains were identified as C. fabianii by sequencing of ITS region, and were 100% identical to the C. fabianii type strain CBS 5640T. However, the MALDI-TOF MS system failed to correctly identify this yeast pathogen. Moreover, isolates from these three clustered cases shared 99.91%-100% identical NTS region sequences, which could not rule out the possibility of an outbreak. However, whole genome sequencing results revealed that only two of the C. fabianii cases were genetically-related with a pairwise SNP of 192 nt, whilst the third case had over 26,000 SNPs on its genome, suggesting a different origin. Furthermore, the genomes of the first three case strains were phylogenetically even more diverged when compared to a C. fabianii strain identified from another patient, who was admitted to a general surgical department of the same hospital 7 months later. One of the first three patients eventually passed away due to poor general conditions, one was asymptomatic, and other clinically improved.ConclusionIn conclusion, nosocomial outbreaks caused by emerging and uncommon fungal species are increasingly being reported, hence awareness must be raised. Genotyping with commonly used universal gene targets may have limited discriminatory power in tracing the sources of infection for these organisms, requiring use of whole genome sequencing to confirm outbreak events.

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“…Methodological problems were identified in 30 out of those 45 studies (corresponding to 22 articles – see Table ). In 17 of those 30 studies (corresponding to 11 articles: Alobaid and Khan, ; Awad et al., ; Bharathi, ; de Paula et al., ; Hasan and Yassein, ; Kaur et al., ; Okmen et al., ; Ruelle et al., ; Soman et al., ; Treguier et al., ; Simi et al., ), a problem was found in respect to the methodology used for identity confirmation of the microorganism, therefore the value of these results and conclusions were very limited. In 2 of those 30 studies (corresponding to 1 article, Awad et al., ), the problem was due to a lack of information regarding the source attribution.…”

Section: Assessmentmentioning

confidence: 99%

“…These 30 articles included description of 45 studies related to different yeast species with QPS status, of which 16 referred to Candida kefyr (teleomorph = Kluyveromyces marxianus ) (Afsarian et al., ; Awad et al., ; Bharathi, ; Diba et al., ; García‐Agudo et al., ; Hasan and Yassein, ; Kaur et al., ; Kesmen et al., ; Khedri et al., ; Nagy et al., ; Okmen et al., ; Omran and Mansori, ; de Paula et al., ; Sadrossadati et al., ; Shokohi et al., ; Simi et al., ), 8 to Saccharomyces cerevisiae including Saccharomyces boulardii (corresponding to 7 articles: Lazo‐Vélez et al., ; Ruelle et al., ; Hasan and Yassein, ; Kara et al., ; Kesmen et al., ; Ochiai et al., ; Teblick et al., ), 10 to Candida famata (teleomorph = Debaryomyces hansenii ) (Afsarian et al., ; Alobaid and Khan, ; Awad et al., ; Cen et al., ; Das et al., ; Diba et al., ; Hasan and Yassein, ; Kesmen et al., ; de Paula et al., ; Simi et al., ), 6 to Candida pelliculosa (synonymus = Pichia anomala , teleomorph = Wickerhamomyces anomalus ) (Ahmadsah et al., ; Arendrup et al., ; Cen et al., ; Jung et al., ; Kesmen et al., ; Soman et al., ), 1 to Candida utilis (teleomorph = Lindnera jadinii ) (Treguier et al., ), 1 to Hanseniaspora uvarum (Kesmen et al., ), 1 Kluyveromyces lactis (Kesmen et al., ) a nd 1 to Schizosaccharomyces pombe (Kesmen et al., ). One of these articles was considered relevant (Pfaller et al., ) to evaluate since it presented new data on antimycotic MIC breakpoints for azoles but it is not associated to any specific yeast TU.…”

Section: Assessmentmentioning

confidence: 99%

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 10: Suitability of taxonomic units notified to EFSA until March 2019

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2019

EFS2

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The qualified presumption of safety (QPS) procedure was developed to provide a harmonised generic preevaluation to support safety risk assessments of biological agents performed by EFSA's Scientific Panels. The taxonomic identity, body of knowledge, safety concerns and antimicrobial resistance were assessed. Safety concerns identified for a taxonomic unit (TU) are, where possible and reasonable in number, reflected by 'qualifications' which should be assessed at the strain level by the EFSA's Scientific Panels. During the current assessment, no new information was found that would change the previously recommended QPS TUs and their qualifications. The list of microorganisms notified to EFSA from applications for market authorisation was updated with 47 biological agents, received between October 2018 and March 2019. Of these, 19 already had QPS status, 20 were excluded from the QPS exercise by the previous QPS mandate (11 filamentous fungi) or from further evaluations within the current mandate (9 notifications of Escherichia coli). Sphingomonas elodea, Gluconobacter frateurii, Corynebacterium ammoniagenes, Corynebacterium casei, Burkholderia ubonensis, Phaeodactylum tricornutum, Microbacterium foliorum and Euglena gracilis were evaluated for the first time. Sphingomonas elodea cannot be assessed for a possible QPS recommendation because it is not a valid species. Corynebacterium ammoniagenes and Euglena gracilis can be recommended for the QPS list with the qualification 'for production purposes only'. The following TUs cannot be recommended for the QPS list: Burkholderia ubonensis, due to its potential and confirmed ability to generate biologically active compounds and limited of body of knowledge; Corynebacterium casei, Gluconobacter frateurii and Microbacterium foliorum, due to lack of body of knowledge; Phaeodactylum tricornutum, based on the lack of a safe history of use in the food chain and limited knowledge on its potential production of bioactive compounds with possible toxic effects.

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Cyberlindnera jadinii (teleomorph Candida utilis) candidaemia in a patient with aplastic anaemia: a case report

Cited by 10 publications

References 8 publications

Candida utilis: a rare cause of septicemia in children

Candida utilis: a rare cause of septicemia in children

A pseudo-outbreak of Cyberlindnera fabianii funguria: Implication from whole genome sequencing assay

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 10: Suitability of taxonomic units notified to EFSA until March 2019

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