Cyclic heptapeptides from the soil-derived fungus Clonostachys rosea

Abdel‐Wahab, Nada M.; Harwoko, Harwoko; Müller, Wernér E.G.; Hamacher, Alexandra; Kassack, Matthias U.; Fouad, Mostafa A.; Kamel, Mohamed S.; Lin, Wenhan; Ebrahim, Weaam; Liu, Zhen; Proksch, Peter

doi:10.1016/j.bmc.2019.07.025

Cited by 13 publications

(18 citation statements)

References 25 publications

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“…Clonostachys rosea - [11] Cyclo-(Gly-D-Leu-D-allo-Ile -D-allo-Ile-L-Val-D-Trp-β-Al a) (11) Clonostachys rosea - [11] Cyclosporin A (12) Nectria sp. F-4908 - [12] Immunosuppressive and antifungal activities [13] Cyclosporin C (13) Nectria sp.…”

Section: Linear Oligopeptidesmentioning

confidence: 99%

“…Y1085 - [17] 11′-Deoxyverticillin A (51) Gliocladium roseum 1A Antinematodal activity [23] 11,11′-Dideoxyverticillin A (52) Bionectria sp. Y1085 - [17] Verticillin B (53) Nectria inventa Trypanocidal activity [18] Verticillin D (54) Bionectria byssicola F120 - [16] Bionectria ochroleuca Cytotoxic activity [4] Clonostachys rosea Cytotoxic activity [11] Verticillin G (55) Bionectria byssicola F120 Antibacterial activity [25] Verticillin H (…”

Section: Ymf100133mentioning

confidence: 99%

“…Verticillins were the dimeric epipolythiodioxopiperazines widely distributed in Bionectriaceous fungi. Most of verticillins exhibited cytotoxic activities [11,27]. Among them, verticillin A (50) showed obviously cytotoxic acitivity by causing apoptosis and reducing tumor burden in high-grade serious ovarian cancer by inducing DNA damage [42].…”

Section: Piperazinesmentioning

confidence: 99%

“…Gliocladiosins A (67) and B (68), as well as rogersonins A (69) and B (70) were alkaloid-polyketide hydrids isolated from gene disruption mutants of Clonostachys rogersoniana [32,33]. Fermentation of the Clonostachys rosea on white beans instead of rice afforded one γ-lactam clonostalactam (62) and two γ-lactones 3,5-dihydroxyfuran-2(5H)-one (141) and sapinofuranone B (142) that were not detected in the former extracts [11]. The apple juice supplemented solid rice media led to significant changes in the secondary metabolism of the fungus, Clonostachys rosea B5-2, and induced the production of four new compounds, (-)-dihydrovertinolide (144), clonostach acids A (219), B (220) and C (221) together with the known compound, (-)-vertinolide (143) [58].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Metabolites from Clonostachys Fungi and Their Biological Activities

Han

Zhang

et al. 2020

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Clonostachys (teleomorph: Bionectria) fungi are well known to produce a variety of secondary metabolites with various biological activities to show their pharmaceutical and agrochemical applications. Up to now, at least 229 secondary metabolites, mainly including 84 nitrogen-containing metabolites, 85 polyketides, 40 terpenoids, and 20 other metabolites, have been reported. Many of these compounds exhibit biological activities, such as cytotoxic, antimicrobial, antileishmanial, antimalarial activities. This mini-review aims to summarize the diversity of the secondary metabolites as well as their occurrences in Clonostachys fungi and biological activities.

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Section: Linear Oligopeptidesmentioning

confidence: 99%

Section: Ymf100133mentioning

confidence: 99%

Section: Piperazinesmentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Metabolites from Clonostachys Fungi and Their Biological Activities

Han

Zhang

et al. 2020

JoF

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“…Clonostachys rosea displayed significant cytotoxicity against L5178Y mouse lymphoma cell lines (IC50 0.1 and 4.1 µM, respectively) [28]. Yu et al investigated metabolites from ascomycete fungus Aphanoascus fulvescens isolated from goose dung [29].…”

Section: Microorganism-derived Compounds and Lymphomamentioning

confidence: 99%

Review of Natural Compounds for the Management and Prevention of Lymphoma

et al. 2020

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Lymphoma is a type of blood cancer that can be categorized into two types-Hodgkin lymphoma (HL) and Non-Hodgkin lymphoma (NHL). A total of 509,590 and 79,990 cases of NHL and HL were newly diagnosed in 2018, respectively. Although conventional therapy has stridden forward over recent decades, its adverse effects are still a hurdle to be solved. Thus, to help researchers develop better lymphoma treatment, this study aims to review the systematic anticancer data for natural products and their compounds. A variety of natural products showed anticancerous effects on lymphoma by regulation of intracellular mechanisms including apoptosis as well as cell cycle arrest. As these results shed light on the potential to substitute conventional therapy with natural products, it may become a promising strategy for lymphoma treatment in the near future.

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