Cyclic nucleotide involvement in histamine release from mast cells — A reevaluation

Alm, Per E.; Bloom, Gunnar D.

doi:10.1016/0024-3205(82)90501-x

Cited by 32 publications

(3 citation statements)

References 24 publications

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“…This would suggest that the inhibitory effects of pertussis toxin on Ge may be more stringent with 48/80 stimulation and that higher concentrations or longer incubation periods are necessary to antagonize GTP[y-S]-induced secretion. The role of cAMP in mast cell secretion is a matter of considerable controversy (35). Most studies, however, assign an inhibitory effect on secretion, based mainly on the inhibitory actions of substances thought to elevate intracellular levels of cAMP (24).…”

Section: Discussionmentioning

confidence: 99%

Multiple signaling pathways control stimulus-secretion coupling in rat peritoneal mast cells.

Penner

1988

Proc. Natl. Acad. Sci. U.S.A.

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Section: Discussionmentioning

confidence: 99%

Multiple signaling pathways control stimulus-secretion coupling in rat peritoneal mast cells.

Penner

1988

Proc. Natl. Acad. Sci. U.S.A.

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“…In contrast, secretory events in cells are generally accompa-nied by decreased levels of cyclic AMP. In mast cells, histamine release is associated with a fall in cAMP 22 . Fenoterol, a LABA with a 12-h duration of action that was recently introduced to treat asthma, inhibits antigen-induced histamine release from basophils or mast cells in a dose-dependent fashion with concomitant increases in cAMP levels 23 .…”

Section: Lipid Raft and Endocytosis Of β2-adrenergic Receptorsmentioning

confidence: 99%

New target for asthma treatment: Inhibition of cluster formation of lipid rafts

Tomita¹,

Schimizu²,

Tohda³

2013

OA Immunology

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Introduction Lipid rafts are microdomains of the plasma membrane that are enriched in cholesterol and sphingolipids and play an important role in the initiation of many pharmacological agentinduced signalling pathways. Basophils or mast cells play roles in the pathophysiology of allergic asthma. Cluster formation of lipid rafts with crosslinking of high-affinity IgE receptor contributes to the activation of basophils or mast cells and the process of granule exocytosis. Antiasthmatic drugs, such as glucocorticoids and β2-agonists, inhibit cluster formation of lipid rafts, via mobility of the membrane and internalisation of β2-adrenergic receptors, respectively. This review highlights the recent findings on this new target of anti-asthma drugs through inhibition of the cluster formation of lipid rafts. Conclusion Future work will be required to determine whether long-acting muscarinic antagonists could inhibit cluster formation of lipid rafts on basophils or mast cells, as well as smooth muscle and gland cells.

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“…Ca 2+ is a central aspect of inflammation as well as inflammatory diseases. In fact, Ca 2+ is thought to be closely associated with the release and metabolism of inflammatory substances such as histamine, prostaglandins and leukotrienes by mast cells during the outbreak of inflammation [ 14 ]. It has been suggested that Ca 2+ can regulate the metabolism of arachidonic acid in T cells and mediate synovial inflammation in RA patients during the inflammatory response [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Calcium-Permeable Channels Cooperation for Rheumatoid Arthritis: Therapeutic Opportunities

Liang

Yin

et al. 2022

Biomolecules

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Rheumatoid arthritis is a common autoimmune disease that results from the deposition of antibodies–autoantigens in the joints, leading to long-lasting inflammation. The main features of RA include cartilage damage, synovial invasion and flare-ups of intra-articular inflammation, and these pathological processes significantly reduce patients’ quality of life. To date, there is still no drug target that can act in rheumatoid arthritis. Therefore, the search for novel drug targets has become urgent. Due to their unique physicochemical properties, calcium ions play an important role in all cellular activities and the body has evolved a rigorous calcium signaling system. Calcium-permeable channels, as the main operators of calcium signaling, are widely distributed in cell membranes, endoplasmic reticulum membranes and mitochondrial membranes, and mediate the efflux and entry of Ca2+. Over the last century, more and more calcium-permeable channels have been identified in human cells, and the role of this large family of calcium-permeable channels in rheumatoid arthritis has gradually become clear. In this review, we briefly introduce the major calcium-permeable channels involved in the pathogenesis of RA (e.g., acid-sensitive ion channel (ASIC), transient receptor potential (TRP) channel and P2X receptor) and explain the specific roles and mechanisms of these calcium-permeable channels in the pathogenesis of RA, providing more comprehensive ideas and targets for the treatment of RA.

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Cyclic nucleotide involvement in histamine release from mast cells — A reevaluation

Cited by 32 publications

References 24 publications

Multiple signaling pathways control stimulus-secretion coupling in rat peritoneal mast cells.

Multiple signaling pathways control stimulus-secretion coupling in rat peritoneal mast cells.

New target for asthma treatment: Inhibition of cluster formation of lipid rafts

Calcium-Permeable Channels Cooperation for Rheumatoid Arthritis: Therapeutic Opportunities

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