Cyclic organophosphorus compounds as possible pesticides. Part I. 1,3,2-Dioxaphospholans

Effect of Particle Size on Ophthalmic Bioavailability of Dexamethasone Suspensions in Rabbits

“…Pharmacokinetics-cimetidine, humans Bioavailability-cimetidine, humans Blood levels of cimetidine in humans after oral dosing (1-8) and intravenous administration (2,5,6) have been analyzed with respect to the pharmacological response (2), influence of a meal on absorption (3), biliary distribution and secretion (4), and bioavailability (1, 5, 6). The drug shows unusual pharmacokinetic behavior in producing a significant secondary peak in the drug concentration profile after oral dosing on a fasting stomach but not after intravenous administration (5)(6)(7). No attempts have been made to describe the pharmacokinetics of the phenomenon.…”

Dissolution rate measurements of sparingly soluble compounds with the Coulter Counter model TAII

“…Edmundson 8~ Lees (1965) used the Coulter Counter to determine the loss in count of particles of hydrocortisone acetate of given diameters as a function of time and calculated from this the dissolution rate of the polydispersed material. The total particulate count was constant and the changes in sizes of the particles changed with time, so the method could be considered to give an intrinsic dissolution rate.…”

The effect of particle size and shape on the flow and failure properties of procaine penicillin powders

“…da was calculated from the weight per unit area of the photographic paper. The values of S (the mean particle surface area) were obtained from air permeability measurements, using a modified Fisher apparatus (Edmundson, 1966) and knowledge of the number of particles per gram, obtained from the Coulter counter analysis. V is the mean particle volume, calculated from the particle density and the number of particles per gram.…”