Cyclin B1 expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma

Obermann, Ellen C.; Went, Philip; Pehrs, Ann Christine; Tzankov, Alexandar; Wild, Peter J.; Pileri, Stefano; Hofstaedter, Ferdinand; Dirnhofer, Stephan

doi:10.3892/or.14.6.1461

Cited by 14 publications

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“…Controversy exists on the prognostic effect of CCND3 (17,19); still, we could not find an association in our cohort. Recently, we showed CCNB1 expression to be of prognostic significance in a large DLBCL series that partially overlapped with the present cases (9). In a multivariate analysis considering the present results, only CCNE seemed to be of prognostic value when compared with CCNB1 (Table 4).…”

Section: Discussionmentioning

confidence: 64%

Diffuse Large B-Cell Lymphoma with Overexpression of Cyclin E Substantiates Poor Standard Treatment Response and Inferior Outcome

Tzankov

Gschwendtner²,

Augustin³

et al. 2006

Clinical Cancer Research

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Purpose: Gold standard to predict survival and stratify patients for risk-adapted therapy in diffuse large B-cell lymphoma (DLBCL) is the international prognostic index, although it does not consider the molecular heterogeneity of DLBCL. Deregulation of cyclin E (CCNE) is a strong predictor of poor prognosis in some neoplastic diseases. In tumor cells, it induces chromosomal instability with an increased rate of aneuploidy/polyploidy. Experimental Design: We analyzed in this retrospective study the prognostic value of immunohistochemical CCNE expression on a validated tissue microarray containing 101de novo DLBCLs and, in 9 cases, the CCNE-induced chromosomal instability as assessed by cytometry. Results: Forty-six of 98 evaluable DLBCLs expressed CCNE in a mean proportion of 20 F 29% of tumor cells; 38 cases expressed CCNE in z20% of tumor cells. CCNE-positive samples were aneuploid compared with near tetraploidy in CCNE-negative cases. Multivariate analysis showed CCNE expression in z20% of tumor cells to be an international prognostic index^independent, Adriamycin-based treatment-independent, and BCL2-independent prognostic factor for poor disease-specific survival. CCNE expression in z80% of tumor cells was associated with dismal short-term prognosis. CCNE expression in z50% of tumor cells emerged as an independent predictive factor for standard CHOP treatment resistance. Conclusions: CCNE expression assessment is easy on paraffin-embedded tissue. The high prognostic value of CCNE expression in DLBCL may be the basis for future prospective trials. In addition, a high CCNE expression hints at the presence of a possible target for individualized cancer therapy.

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Section: Discussionmentioning

confidence: 64%

Diffuse Large B-Cell Lymphoma with Overexpression of Cyclin E Substantiates Poor Standard Treatment Response and Inferior Outcome

Tzankov

Gschwendtner²,

Augustin³

et al. 2006

Clinical Cancer Research

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“…Overexpression of these proliferative regulators was demonstrated in rapidly proliferating cells (41)(42)(43). The nuclear translocalization of cyclin B1 and Plk1 from cytoplasm occurs at the G 2 /M transition and contributes to mitotic progression (19).…”

Section: Discussionmentioning

confidence: 99%

High expression levels of cyclin B1 and Polo-like kinase 1 in ectopic endometrial cells associated with abnormal cell cycle regulation of endometriosis

Tang

Wang

et al. 2009

Fertility and Sterility

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“…Although markers distinctive for cell-cycle regulation in DLBCL have been addressed in detail in earlier studies, less attention has been paid to cyclin H in DLBCL with respect to its prognostic and potential therapeutic implications [5][6][7][8][9][10][11][12][13][14]. Cyclin H is a part of cyclin H/Cdk7/Mat1 complex, which is necessary for cellular proliferation [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma

et al. 2008

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Cyclin B1 expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma

Cited by 14 publications

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Diffuse Large B-Cell Lymphoma with Overexpression of Cyclin E Substantiates Poor Standard Treatment Response and Inferior Outcome

Diffuse Large B-Cell Lymphoma with Overexpression of Cyclin E Substantiates Poor Standard Treatment Response and Inferior Outcome

High expression levels of cyclin B1 and Polo-like kinase 1 in ectopic endometrial cells associated with abnormal cell cycle regulation of endometriosis

Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma

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