2001
DOI: 10.1002/1097-0215(20010720)95:4<209::aid-ijc1036>3.0.co;2-r
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Cyclin D1-CDK4 complex, a possible critical factor for cell proliferation and prognosis in laryngeal squamous cell carcinomas

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Cited by 83 publications
(60 citation statements)
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“…These findings strongly suggest that the expression level of CDK4 and MYB may be associated with the development of leukemia. Aberrant expression of CDK4 was previously shown to associate with differentiation of liposarcoma and enhanced proliferation of laryngeal cancer cells (28,29). In addition, Weber et al (30) showed that alternative splicing of the c-MYB mRNA resulting in enhanced MYB expression occurred in hematologic malignancies and caused excessive proliferation and differentiation of the malignant cells.…”
Section: Discussionmentioning
confidence: 97%
“…These findings strongly suggest that the expression level of CDK4 and MYB may be associated with the development of leukemia. Aberrant expression of CDK4 was previously shown to associate with differentiation of liposarcoma and enhanced proliferation of laryngeal cancer cells (28,29). In addition, Weber et al (30) showed that alternative splicing of the c-MYB mRNA resulting in enhanced MYB expression occurred in hematologic malignancies and caused excessive proliferation and differentiation of the malignant cells.…”
Section: Discussionmentioning
confidence: 97%
“…PAH is diagnosed when the mean pulmonary arterial pressure exceeds 25 mmHg, as measured by right-heart catheterization (18). Although advances have been made in the understanding of PAH and development of treatments, research into effective therapies is still required to improve the long-term survival of patients with fewer side effects than current treatments exert.…”
Section: Discussionmentioning
confidence: 99%
“…The cell cycle is regulated by cyclin-dependent kinases (CDK) and CDK inhibitors, which have been key therapeutic targets in treating vascular proliferation-associated diseases (16). Cyclin D1 is the key cell cycle control gene that facilitates the transition of cells from the G 1 phase into the S phase (18). A previous study demonstrated that inhibition of cyclin D1 could inhibit VSMC proliferation (30).…”
Section: Discussionmentioning
confidence: 99%
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“…CDK4 is required for cell cycle G 1 phase progression (25). Dong et al (26) reported that CDK4 was overexpressed in LSCC and suggested that it may have a critical role in cell proliferation together with cyclin D1. MCM2 has been implicated in the initiation of eukaryotic genome replication, which has been proposed as a marker of dysplasia and malignancy (27).…”
Section: Discussionmentioning
confidence: 99%