Cyclin D1 expression in prostate carcinoma

Abstract

The purpose of this study was to investigate the relationship between cyclin D1 expression and clinicopathological parameters in patients with prostate carcinoma. We assessed cyclin D1 expression by conventional immunohistochemistry in 85 patients who underwent radical prostatectomy for prostate carcinoma and 10 normal prostate tissue samples retrieved from autopsies. We measured nuclear immunostaining in the entire tumor area and based the results on the percentage of positive tumor cells. The preoperative prostate-specific antigen (PSA) level was 8.68±5.16 ng/mL (mean±SD). Cyclin D1 staining was positive (cyclin D1 expression in >5% of tumor cells) in 64 cases (75.4%) and negative (cyclin D1 expression in ≤5% of tumor cells) in 21 cases (including 15 cases with no immunostaining). Normal prostate tissues were negative for cyclin D1. Among patients with a high-grade Gleason score (≥7), 86% of patients demonstrated cyclin D1 immunostaining of >5% (P<0.05). In the crude analysis of cyclin D1 expression, the high-grade Gleason score group showed a mean expression of 39.6%, compared to 26.9% in the low-grade Gleason score group (P<0.05). Perineural invasion tended to be associated with cyclin D1 expression (P=0.07), whereas cyclin D1 expression was not associated with PSA levels or other parameters. Our results suggest that high cyclin D1 expression could be a potential marker for tumor aggressiveness.

Immunohistochemical expression of Cyclin D1 among Sudanese patients diagnosed with benign and malignant prostatic lesions

“…In this study, the relation between Gleason Scoring and Cyclin D1 expression were in harmony to previous reports, showing a positive relationship between the expression of Cyclin D1 and Gleason score, especially with high-grade tumors [8,22,[29][30][31]. While in comparison to other studies, no association was found [29,33,34].…”

“…Correspondingly to previous reports [8,[29][30][31][32], that stated a significant association especially with high-grade tumors, in this study the reported correlation of Cyclin D1 and Gleason score was statistically significant (P value= 0,001). While in another study expression of Cyclin D1 in BPH was not detected [31], and in another study, although Cyclin D1 is expressed in BPH, rarely Cyclin D1 is overexpressed in cases of PC [26].…”

“…High expression of Cyclin D1 was noticed among different types of malignancy, including Breast cancer [4], colon cancer [5], and lung cancer [6,7]. There are many studies that investigated the role of Cyclin D1 expression in PC; Pereira et al, correlated the expression of Cyclin D1 to be associated with perineural invasions and with the aggressive form of the disease [8].…”

Immunohistochemical expression of Cyclin D1 among Sudanese patients diagnosed with benign and malignant prostatic lesions

“…As well, due to the predictive preoperative usefulness of the Gleason score correlated with Cyclin D1 expression to predict tumor behavior, it became easy to differentiate between malignant and benign disease [37,38]. However, in some studies, Gleason score did not satisfy that theme [8,[39][40][41].…”

Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer

“…Over-expression of cyclin D1 shortens the G1-S transition, thus promoting tumorigenesis and cancer recurrence in diverse human cancers [229,230]. In PCa, cyclin D1 expression is upregulated and correlated with high-grade Gleason score [231]. Cyclin D1 also leads to transformation of androgen-independent state through the upregulation of MDM2 [232].…”