2006
DOI: 10.4161/cc.5.21.3428
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Cyclin D1 Functions in Cell Migration

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Cited by 109 publications
(103 citation statements)
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References 37 publications
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“…It is known that cyclin D1 has functions other than those related directly to cellular proliferation including influences on cellular adhesion and migration. 16 Further studies are required to determine the significance of focal cyclin D1 expression in cervical adenocarcinoma but the present findings further illustrate the importance of considering microanatomical variations in staining patterns, even if these are restricted to a minority of cells, as they may be relevant to tumor progression. 33,34 Disclosure/conflict of interest…”
Section: Discussionmentioning
confidence: 69%
See 1 more Smart Citation
“…It is known that cyclin D1 has functions other than those related directly to cellular proliferation including influences on cellular adhesion and migration. 16 Further studies are required to determine the significance of focal cyclin D1 expression in cervical adenocarcinoma but the present findings further illustrate the importance of considering microanatomical variations in staining patterns, even if these are restricted to a minority of cells, as they may be relevant to tumor progression. 33,34 Disclosure/conflict of interest…”
Section: Discussionmentioning
confidence: 69%
“…Cyclin D1 also exhibits CDK-independent activities that influence apoptotic pathways, cellular migration, and angiogenesis all of which may be important in the neoplastic context. [10][11][12]16 Over-expression of cyclin D1 has been documented in diverse neoplasms including breast carcinoma, head and neck squamous carcinoma, parathyroid adenoma and mantle cell lymphoma, and some studies have shown a correlation between increased cyclin D1 and adverse prognosis. Therefore, our observation that cyclin D1 immunoreactivity was usually lost in neoplastic endocervical lesions seemed to be a counter-intuitive finding, particularly as such lesions are known to show prominent mitotic activity.…”
Section: Discussionmentioning
confidence: 99%
“…36 Cyclin D1 and its binding partner Cdk4 are known important regulators of cell migration, invasion as well as cell cycle progression from G 1 to S phase in different cell types. 37,38 Expression of cyclin D1 forms active complexes that promote cell cycle progression via phosphorylation and inhibition of the retinoblastoma protein and are linked to the development of several forms of carcinoma. 39 Cdk4 is a member of the Ser/Thr protein kinase family that serves as a catalytic subunit of the protein kinase complex involved in G 1 -phase progression of cell cycle.…”
Section: Rna Isolation and Reverse Transcription-pcr (Rt-pcr)mentioning
confidence: 99%
“…Cell-cycle arrest is believed to be involved in the antiproliferative action of MK-4 (2-4, 6, 37, 38). Aberrant expression of NF-kB is linked to cyclin D1 (5), and to the onset and progression of HCC tumorigenesis (38), and both cyclin D1 and NF-kB regulate cellular migration (39,40). The inhibition of both NF-kB and cyclin D1 may contribute to the suppression of HCC cell proliferation and invasion.…”
Section: Effects Of Mkh-dmg On Cell-cycle Arrest In Hcc Cellsmentioning
confidence: 99%