Cyclin D1 G870A polymorphism is associated with an increased risk of hepatocellular carcinoma in the Turkish population: Case–control study

Akkız, Hikmet; Bayram, Süleyman; Bekar, Aynur; Akgöllü, Ersin; Özdil, Burhan

doi:10.1016/j.canep.2010.02.011

Cited by 31 publications

(40 citation statements)

References 32 publications

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“…In the study by Pakakasama et al (2004), which described the association between the G870A SNP and hepatocellular carcinoma risk in 3 races, the distribution of the G870A genotypes in controls of Hispanics were not in accordance with HWE and this study was therefore excluded from the meta-analysis. The study by Pakakasama et al (2004) examining African Americans and Caucasians and 3 other studies (Zhang et al, 2002;Akkiz et al, 2010;Hu et al, 2014), containing 540 cases and 626 controls, were included in the meta-analysis to determine the role of the G870A polymorphism on hepatocellular carcinoma risk. Figure 2 shows the main results of this meta-analysis regarding the association between the CCND1 G870A polymorphism and the susceptibility to leukemia.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The relationships between the G870A SNP and excessive CCND1 activity, as well as numerous human tumors, have been studied in recent years, including primary brain tumors, bladder cancer, colorectal cancer, esophageal cancer, hepatocellular carcinoma, leukemia, and breast cancer (Akkiz et al, 2010;Zhuo et al, 2012;Bedewy et al, 2013;Sameer et al, 2013;Zeybek et al, 2013;Li et al, 2014). Among these, the numerous relevant epidemiologic studies investigating the relationship between the CCND1 G870A variant and hepatocellular carcinoma (Zhang et al, 2002;Pakakasama et al, 2004;Akkiz et al, 2010;Hu et al, 2014) or leukemia (Howe and Lynas, 2001;Hou et al, 2005;Bedewy et al 2013) have yielded conflicting and controversial results.…”

Section: Introductionmentioning

confidence: 99%

“…Among these, the numerous relevant epidemiologic studies investigating the relationship between the CCND1 G870A variant and hepatocellular carcinoma (Zhang et al, 2002;Pakakasama et al, 2004;Akkiz et al, 2010;Hu et al, 2014) or leukemia (Howe and Lynas, 2001;Hou et al, 2005;Bedewy et al 2013) have yielded conflicting and controversial results. There has been no systematic or quantitative assessment of the published findings on this topic.…”

Section: Introductionmentioning

confidence: 99%

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Cyclin D1 G870A gene polymorphism and risk of leukemia and hepatocellular carcinoma: a meta-analysis

Zhao¹,

He²,

Wang³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Cyclin D1 (CCND1) is a key protein involved in cellcycle regulation, and the CCND1 G870A polymorphism is associated with many types of malignancy. Studies examining the associations between this G870A polymorphism and susceptibility to leukemia and hepatocellular carcinoma (HCC) have shown inconsistent results. Therefore, we conducted a meta-analysis to clarify these associations. A search of the PubMed database yielded 7 relevant articles: 3 pertaining to leukemia and 4 to HCC. The odds ratios (ORs) from individual studies were pooled using a fixed or random-effect model. A significant association was observed between the CCND1 G870A variant and leukemia under the allele contrast model [P = 0.003, OR = 1.49, 95% confidence interval (CI) = 1.15-1.95], the homozygote contrast model (P = 0.003, OR = 2.30, 95%CI = 1.34-3.96), and the recessive model (P = 0.002, OR = 2.03, 95%CI = 1.29-3.21). A significant association was observed between this variant and HCC under the recessive model (P = Y. Zhao et al. 5172©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 5171-5180 (2015) 0.0006, OR = 1.62, 95%CI = 1.23-2.14), the dominant model (P = 0.002, OR = 1.59, 95%CI = 1.19-2.14), the homozygote contrast model (P < 0.0001, OR = 2.06, 95%CI = 1.45-2.94), and the allele contrast model (P < 0.0001, OR = 1.43, 95%CI = 1.20-1.69). Our findings suggest that heritable CCND1 status may influence the risk of developing leukemia and HCC, and that more attention should be given to carriers of these susceptibility genes.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cyclin D1 G870A gene polymorphism and risk of leukemia and hepatocellular carcinoma: a meta-analysis

Zhao¹,

He²,

Wang³

et al. 2015

Genet. Mol. Res.

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“…Several studies have identified a correlation between the CCND1 870A allele and an increased cancer risk, including bladder , prostate ,liver and breast cancer (Wang et al, 2002;Wang et al, 2003;Akkiz et al, 2010;Canbay et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Specific CCND1 G870A Alleles Associated with Breast Cancer Susceptibility: a Meta-analysis of 5,528 Cases and 5,353 Controls

Cui

Shen²,

Wang³

2012

Asian Pacific Journal of Cancer Prevention

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Background: The Cyclin D1(CCND1) G870A polymorphism may be associated with breast cancer, but the evidence from individual studies is inconclusive. The aim of this study was to investigate the correlation between the CCND1 G870A polymorphism and breast cancer risk in a meta-analysis. Materials and Methods: We searched Pubmed and analysed 11 articles on 5,528 cases and 5,353 controls before February 1, 2012. Results: we found there are significant association for AA versus GG and AA versus GA/GG. No significant associations were found for GA versus GG, GA/AA versus GG. There are significant association for AA versus GG ,and AA versus GA/GG in Caucasians. We didn't find any significant main effects for G870A polymorphism on breast cancer risk either in recessive or dominant models in Asians. Conclusion: This meta-analysis suggests that AA of the CCND1 G870A polymorphism is associated with breast cancer susceptibility.

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“…Some studies indicate that the CCND1 gene has a G to A polymorphism, and the CCND1 870A allele expresses transcript B (cyclin D1b), which affects the risk of malignant tumors (Betticher et al, 1995;Bala et al, 2001;Qiuling et al, 2003;Wang et al, 2003). CCND1 gene has been reported in various tumors (Akkiz et al, 2010;Yang et al, 2012;Wang et al, 2014). Similarly, the CCND1 G870A gene polymorphism also has been reported in various tumors in Asian Pacific journal of cancer prevention (APJCP) during the last two years, but the results of previous studies were inconsistent (Li et al, 2012;Zeybek et al, 2013).…”

mentioning

confidence: 99%

The CCND1 G870A Gene Polymorphism and Leukemia or Non-Hodgkin Lymphoma Risk: a Meta-analysis

Qin

Zhao²,

Chen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Cyclin D1 G870A polymorphism is associated with an increased risk of hepatocellular carcinoma in the Turkish population: Case–control study

Abstract: Our results suggest that the CCND1 G870A single nucleotide polymorphism is associated with an increased risk of HCC in our Turkish population.

Cited by 31 publications

References 32 publications

Cyclin D1 G870A gene polymorphism and risk of leukemia and hepatocellular carcinoma: a meta-analysis

Cyclin D1 G870A gene polymorphism and risk of leukemia and hepatocellular carcinoma: a meta-analysis

Specific CCND1 G870A Alleles Associated with Breast Cancer Susceptibility: a Meta-analysis of 5,528 Cases and 5,353 Controls

The CCND1 G870A Gene Polymorphism and Leukemia or Non-Hodgkin Lymphoma Risk: a Meta-analysis

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