Cyclo-oxygenase-2 Over-expression Is Associated with Human Esophageal Squamous Cell Carcinoma

Miyashita, Masao; Makino, Hiroshi; Katsuta, Miwako; Nomura, Tsutomu; Shinji, Seiichi; Kashiwabara, Moto; Takahashi, Ken; Kudo, Mitsuhiro; Ishiwata, Toshiyuki; Naito, Zenya; Tajiri, Takashi

doi:10.1272/jnms.73.308

Cited by 10 publications

(10 citation statements)

References 24 publications

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“…The percentage of high/positive COX-2 expression was >50% in 15 studies,6,8,10,11,13–19,21,22,31,34,36 and the remaining 10 studies shared the percentage of high/positive COX-2 expression <50% 7,9,12,20,21,23,24,32,33. Among these studies, ESCC was investigated in 17 studies,6,9–13,16,18,19,21–24, 31–34,36 EADC was investigated in 5 studies,7,8,14,17 and another 3 studies evaluated both histological types 15,20,21. The patients in 17 studies were treated by surgery only;7–11,13–15,17,19,21,22,24,31,33,34 the surgery plus additional chemotherapy or radiotherapy was applied in 8 studies 6,12,16,18,20,23,32,36…”

Section: Resultsmentioning

confidence: 97%

“…Eighteen studies were conducted on Asian patients,6,9–13,16,18,19,21–24,31,33–36 and 7 studies were conducted on Caucasian patients 7,8,14,15,17,20,32. The percentage of high/positive COX-2 expression was >50% in 15 studies,6,8,10,11,13–19,21,22,31,34,36 and the remaining 10 studies shared the percentage of high/positive COX-2 expression <50% 7,9,12,20,21,23,24,32,33. Among these studies, ESCC was investigated in 17 studies,6,9–13,16,18,19,21–24, 31–34,36 EADC was investigated in 5 studies,7,8,14,17 and another 3 studies evaluated both histological types 15,20,21.…”

Section: Resultsmentioning

confidence: 99%

“…Among these studies, ESCC was investigated in 17 studies,6,9–13,16,18,19,21–24, 31–34,36 EADC was investigated in 5 studies,7,8,14,17 and another 3 studies evaluated both histological types 15,20,21. The patients in 17 studies were treated by surgery only;7–11,13–15,17,19,21,22,24,31,33,34 the surgery plus additional chemotherapy or radiotherapy was applied in 8 studies 6,12,16,18,20,23,32,36…”

Section: Resultsmentioning

confidence: 99%

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The prognostic value of cyclooxygenase-2 expression in patients with esophageal cancer: evidence from a meta-analysis

Hu¹,

Yang

Zhao

et al. 2017

OTT

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Published studies have investigated the prognostic role of cyclooxygenase-2 (COX-2) expression in patients with esophageal cancer (EC), but the result remains controversial. Thus, this meta-analysis was conducted to comprehensively evaluate the impact of COX-2 expression on the prognostic value in patients with EC. Relevant studies were identified from PubMed, EMBASE, and Web of Science databases. Studies that detected the COX-2 expression by immunohistochemistry and evaluated the relationship between COX-2 expression and overall survival (OS) or clinicopathological parameters were used in our analysis. The summary hazard ratios (HRs) or odds ratios were calculated to assess the risk or hazard association. A total of 25 studies, which included 2,465 patients, were included in our meta-analysis. Our analysis suggested that overexpression of COX-2 was associated with poor OS (HR =1.60, 95% CI =1.32–1.94, P<0.001). Subgroup analyses by race, percentage of high/positive COX-2 expression, histology type, treatment, and sample size all suggested significant association. Moreover, overexpression of COX-2 was significantly associated with depth of invasion, lymph node metastasis, distant metastasis, and TNM stage. This meta-analysis suggested that overexpression of COX-2 might serve as a prognostic biomarker for EC. Large well-designed prospective studies are needed to confirm our conclusion.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The prognostic value of cyclooxygenase-2 expression in patients with esophageal cancer: evidence from a meta-analysis

Hu¹,

Yang

Zhao

et al. 2017

OTT

View full text Add to dashboard Cite

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“…A total of 19 studies [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] published from 2000 to 2008 met the criteria for this review. The total number of patients was 1608, ranging from 31 to 228 patients per study.…”

Section: Study Characteristicsmentioning

confidence: 99%

Meta‐analysis: clinicopathological and prognostic significance of cyclooxygenase‐2 expression on oesophageal squamous cell carinoma

Wang

et al. 2009

Aliment Pharmacol Ther

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“…NSAIDs induce cell apoptosis and inhibit angiogenesis of tumor through suppressing the activity of COX-2, suggesting COX-2 might be used as a possible target for the treatment of tongue cancer [4]. COX-2 has been found to be overexpressed in many types of cancers, including laryngeal squamous cell carcinoma, breast cancer, lung cancer, gastric cancer, esophageal cancer, colon cancer, ovarian cancer, and hepatocellular carcinoma with low survival rate and poor prognosis [5][6][7][8][9][10][11][12]. In addition, previous studies showed that COX-2 promoted cell proliferation, angiogenesis, tumor invasion, and metastasis.…”

Section: Introductionmentioning

confidence: 99%

COX-2 Gene increases tongue cancer cell proliferation and invasion through VEGF-C pathway

Wang

Yang

et al. 2010

Med Oncol

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COX-2 induces the proliferation and invasion of oral squamous cell carcinoma. In the present study, the role of the COX-2 gene in the tongue cancer cell proliferation and invasion was investigated. A short hairpin RNA (shRNA)method was used to knock down COX-2 gene expression and investigate the relationship between COX-2 and VEGF-C, and the role of the COX-2 gene for proliferation and invasion was also investigated in the tongue cancer cell Tca8113. COX-2 gene overexpressed in tongue cancer cell line. Suppressing the expression of COX-2 by shRNA could decrease cell proliferation comparing with control shRNA. Nevertheless, depressing COX-2 gene expression by shRNA reduced VEGF-C expression on both mRNA and protein levels. VEGF-C gene expression could be regulated by COX-2 gene. Our results suggested that COX-2 played essential roles in the proliferation and metastasis of tongue cancer, and COX-2 could serve as a potential chemotherapy target for tongue cancer.

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Cyclo-oxygenase-2 Over-expression Is Associated with Human Esophageal Squamous Cell Carcinoma

Cited by 10 publications

References 24 publications

The prognostic value of cyclooxygenase-2 expression in patients with esophageal cancer: evidence from a meta-analysis

The prognostic value of cyclooxygenase-2 expression in patients with esophageal cancer: evidence from a meta-analysis

Meta‐analysis: clinicopathological and prognostic significance of cyclooxygenase‐2 expression on oesophageal squamous cell carinoma

COX-2 Gene increases tongue cancer cell proliferation and invasion through VEGF-C pathway

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