Cyclodextrin-Based Magnetic Nanoparticles for Cancer Therapy

Mrówczyński, Radosław; Jędrzak, Artur; Szutkowski, Kosma; Grześkowiak, Bartosz F.; Coy, Emerson; Markiewicz, Roksana; Jesionowski, Teofil; Jurga, Stefan

doi:10.3390/nano8030170

Cited by 68 publications

(44 citation statements)

References 56 publications

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“…Moreover, to increase the selectivity of the targeting, an EGFR antibody can be located on the surface of these nanoparticles [ 106 ]. IONs coated with PDA can be also modified with 6-thio- β -cyclodextrin and loaded with DOX [ 107 ].…”

Section: Iron Oxide Nanoparticles For Photothermal Therapymentioning

confidence: 99%

Iron Oxide Nanoparticles in Photothermal Therapy

2018

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Photothermal therapy is a kind of therapy based on increasing the temperature of tumoral cells above 42 °C. To this aim, cells must be illuminated with a laser, and the energy of the radiation is transformed in heat. Usually, the employed radiation belongs to the near-infrared radiation range. At this range, the absorption and scattering of the radiation by the body is minimal. Thus, tissues are almost transparent. To improve the efficacy and selectivity of the energy-to-heat transduction, a light-absorbing material, the photothermal agent, must be introduced into the tumor. At present, a vast array of compounds are available as photothermal agents. Among the substances used as photothermal agents, gold-based compounds are one of the most employed. However, the undefined toxicity of this metal hinders their clinical investigations in the long run. Magnetic nanoparticles are a good alternative for use as a photothermal agent in the treatment of tumors. Such nanoparticles, especially those formed by iron oxides, can be used in combination with other substances or used themselves as photothermal agents. The combination of magnetic nanoparticles with other photothermal agents adds more capabilities to the therapeutic system: the nanoparticles can be directed magnetically to the site of interest (the tumor) and their distribution in tumors and other organs can be imaged. When used alone, magnetic nanoparticles present, in theory, an important limitation: their molar absorption coefficient in the near infrared region is low. The controlled clustering of the nanoparticles can solve this drawback. In such conditions, the absorption of the indicated radiation is higher and the conversion of energy in heat is more efficient than in individual nanoparticles. On the other hand, it can be designed as a therapeutic system, in which the heat generated by magnetic nanoparticles after irradiation with infrared light can release a drug attached to the nanoparticles in a controlled manner. This form of targeted drug delivery seems to be a promising tool of chemo-phototherapy. Finally, the heating efficiency of iron oxide nanoparticles can be increased if the infrared radiation is combined with an alternating magnetic field.

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Section: Iron Oxide Nanoparticles For Photothermal Therapymentioning

confidence: 99%

Iron Oxide Nanoparticles in Photothermal Therapy

2018

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“…[143][144][145] Table 4. [149][150][151][152][153][154][155][156][157][158][159][160][161][162][163]…”

Section: An Account Of Recent Advances In Cds For Optimal Drug Deliveryunclassified

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

2020

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Colloidal nanoparticulate technology has been described in the literature as a versatile drug delivery system. But it possesses some inherent lacunae in their formulation. Cyclodextrins (CDs) have been extensively reported for the solubility enhancement of poorly water-soluble drugs. The CDs can cause intervention in aspects related to nanoparticles (NPs) that include improving drug loading in nano-system, improving stability, site-specific/targeted drug delivery, improving solubility profile and absorption of the drug in nanosystem with consequent improvement in bioavailability, with the possibility of controlled release, safety and efficacy. They find application in for simultaneous diagnosis and therapeutics for better treatment procedures. The current communication is focused on the application of CDs to overcome troubles in nanoparticulate formulation and enhancement of their performance. It also envisages the theranostic aspects of CDs.

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“…At the implant site, an infection develops, which spreads to the whole body and may cause life-threatening complications [ 6 , 7 ]. To reduce the likelihood of infection, many different antibiotics are administered to patients at high doses, which may cause bacterial mutations and increase their drug resistance [ 8 , 9 ]. Many compounds and materials with antibacterial properties have been developed to prevent bacterial infections, including quaternary ammonium compounds [ 10 ], carbon nanotubes [ 11 ], metal ions [ 12 ], metal oxide molecules [ 13 ], and precious metal-based materials [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrothermally Assisted Fabrication of TiO2-Fe3O4 Composite Materials and Their Antibacterial Activity

et al. 2020

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The TiO2-Fe3O4 composite materials were fabricated via the hydrothermal-assisted technique. It was determined how the molar ratio of TiO2 to Fe3O4 influences the crystalline structure and morphology of the synthesized composite materials. The effect of the molar ratio of components on the antibacterial activity was also analyzed. On the basis of XRD patterns for the obtained titanium(IV) oxide-iron(II, III) oxide composites, the two separate crystalline forms—anatase and magnetite —were observed. Transmission electron microscopy revealed particles of cubic and tetragonal shape for TiO2 and spherical for Fe3O4. The results of low-temperature nitrogen sorption analysis indicated that an increase in the iron(II, III) oxide content leads to a decrease in the BET surface area. Moreover, the superparamagnetic properties of titanium(IV) oxide-iron(II, III) oxide composites should be noted. An important aim of the work was to determine the antibacterial activity of selected TiO2-Fe3O4 materials. For this purpose, two representative strains of bacteria, the Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus, were used. The titanium(IV) oxide-iron(II, III) oxide composites demonstrated a large zone of growth inhibition for both Gram-positive and Gram-negative bacteria. Moreover, it was found that the analyzed materials can be reused as antibacterial agents in three consecutive cycles with good results.

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Cyclodextrin-Based Magnetic Nanoparticles for Cancer Therapy

Cited by 68 publications

References 56 publications

Iron Oxide Nanoparticles in Photothermal Therapy

Iron Oxide Nanoparticles in Photothermal Therapy

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

Hydrothermally Assisted Fabrication of TiO2-Fe3O4 Composite Materials and Their Antibacterial Activity

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