Cyclodextrin-based metal-organic frameworks particles as efficient carriers for lansoprazole: Study of morphology and chemical composition of individual particles

Li, Xue; Guo, Tao; Lachmanski, Laurent; Manoli, Francesco; Menéndez-Miranda, Mario; Manet, Ilse; Guo, Zhen; Wu, Li; Zhang, Jiwen; Gref, Ruxandra

doi:10.1016/j.ijpharm.2017.05.056

Cited by 77 publications

(39 citation statements)

References 22 publications

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“…Raman spectra exhibit the peak which confirms the uniform distribution of lansoprazole in an individual particle and inclusion complexation of lansoprazole with γCyD-MOF. [77] The current studies provide evidence that CyD-MOF is a promising carrier system for drug delivery.…”

Section: Cyclodextrin-metal-organic Framework (Cyd-mofs) Materialsmentioning

confidence: 74%

Recent Advances in Host–Guest Self‐Assembled Cyclodextrin Carriers: Implications for Responsive Drug Delivery and Biomedical Engineering

Wankar

Kotla

Gera

et al. 2020

Adv Funct Materials

371

220

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This Review is an overview of the unique characteristics of cyclodextrin in forming an inclusion complex via host-guest noncovalent interactions. The modification of cyclodextrin advances its application as a pharmaceutical solubilizer, fabrication of functional molecular machines such as polyrotaxane, polypseudorotaxane, and polycatenanes and grafting of cyclodextrin with different linear, branched chain polymers. The different stimuli-based supramolecular assemblies involving cyclodextrin as a key mediator with linked triggering responses on payload release is highlighted. In addition, the applications of cyclodextrin in diagnostic imaging and medical devices is briefly demonstrated. Cyclodextrin is a relatively low cost, biocompatible, biodegradable, and highly explored material with low toxicity for drug formulation, drug delivery, and wide varieties of other biomedical applications such as those in medical devices fabrication, biosensor, tissue engineering, and bio-imaging. The toxicological profile of cyclodextrin is well established and safe for human consumption in food and medicine.

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Section: Cyclodextrin-metal-organic Framework (Cyd-mofs) Materialsmentioning

confidence: 74%

Recent Advances in Host–Guest Self‐Assembled Cyclodextrin Carriers: Implications for Responsive Drug Delivery and Biomedical Engineering

Wankar

Kotla

Gera

et al. 2020

Adv Funct Materials

371

220

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“…The interaction of the drug captopril and γ ‐CD‐MOFs also relies mainly on van der Waals forces, as the COOH, SH and O groups of captopril formed hydrogen bonds with the OH group of γ ‐CD‐MOFs 33 . A study of CD‐based MOF particles as efficient carriers for lansoprazole also showed van der Waals interactions and Coulomb potentials for electrostatic interactions between the host and guest molecules 18 . Therefore, the absorption characteristics (frequency and shape) of infrared spectrum of corresponding functional groups remained unchanged before and after inclusion.…”

Section: Resultsmentioning

confidence: 99%

“…To solve these problems, metal–organic frameworks (MOFs) have been developed, that is network‐structure crystal materials based on CDs with metal ions or metal clusters 14–17 . In particular, β ‐CD could be used as a ligand to synthesize environment‐friendly and biocompatible MOFs 18,19 . β ‐CD‐MOFs exhibit biocompatibility and reproducibility, and their high specific surface area, large pore size, strong biodegradability and strong encapsulation capacity give them potential applications as new microcapsule embedding materials in the pharmaceutical and food industries 20 …”

Section: Introductionmentioning

confidence: 99%

Improvement of the stabilities and antioxidant activities of polyphenols from the leaves of Chinese star anise (Illicium verum Hook. f.) using β‐cyclodextrin‐based metal–organic frameworks

Wang

et al. 2020

J Sci Food Agric

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BACKGROUND Polyphenols extracted from plants are usually highly unstable and rapidly transformed into various reaction products during food and drug processing, thus limiting their applications. To improve the stability and solubility of polyphenols from the leaves of Chinese star anise (Illicium verum Hook. f.), and hence to expand their application to food and medicine, the extracted anise leaf polyphenols (ALPs) were microencapsulated using β‐cyclodextrin (β‐CD) and cyclodextrin‐based metal–organic frameworks (β‐CD‐MOFs). RESULTS The optimum inclusion rate of ALP/β‐CD‐MOFs was 97.80% at a core–wall ratio of 1:10. Meanwhile, the stabilities, solubilities and antioxidant activities of the polyphenols before and after inclusion were compared. The results showed both the stabilities and solubilities of ALP/β‐CD‐MOFs were significantly improved compared with those of ALPs and ALP/β‐CD, suggesting the potential of β‐CD‐MOFs as newer and better carriers than β‐CD for polyphenols in food industry applications. The free radical (including superoxide, hydroxyl and DPPH radicals) scavenging activities were also improved by microencapsulation. Superoxide radical scavenging reaction also showed slow‐release property of ALP/β‐CD‐MOFs. The formation of the inclusion complex was further confirmed using Fourier transform infrared spectral characterization. CONCLUSIONS Microencapsulation with β‐CD‐MOFs could expand the application scope of ALPs, and it is more effective than encapsulation with β‐CD. This is important for a better understanding and application of this useful traditional Chinese plant. As a new material with high efficiency and edibility, β‐CD‐MOFs are not limited to the chemical field, but also have potential in new areas of food, medicine and healthcare products. © 2020 Society of Chemical Industry

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“…e main features of CD-MOFs are large surface area, biocompatibility and amphiphilicity. erefore, various molecules and drugs can be introduced into the nanopores of CD-MOF by adsorption (Liu et al, 2016(Liu et al, , 2017Moussa et al, 2016;Abucafy et al, 2018;Nagai et al, 2018b) and the cocrystallization technique (Smaldone et al, 2010;Michida et al, 2015Michida et al, , 2018aLi et al, 2017;Nagai et al, 2018a). In either technique, it is di cult to encapsulate water insoluble molecules into CD-MOF.…”

Section: Introductionmentioning

confidence: 99%

Co-Oligomerization of Electroconductive Monomers in a Cyclodextrin-Based Metal–Organic Framework

Kusakabe

Nagai

Nagao

et al. 2020

J. Chem. Eng. Japan / JCEJ

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Encapsulation of both 3,4-ethylenedioxythiophene (EDOT) and terthiophene (TTh) into a cyclodextrin-based metalorganic framework (CD-MOF) was successfully achieved upon use of an adsorption technique. The average amount of EDOT introduced into the CD-MOF was calculated to be 4.3 molecules per hydrophilic nanopore. On the other hand, from the relationship between the molecular size of TTh and the nanopore volume, TTh was evaluated and found to be mostly isolated in each hydrophobic nanopore of the CD-MOF. Co-oligomerization of EDOT and TTh in a CD-MOF was initiated by exposure to I 2 vapor and subsequent heating at 80°C for 6 h. A trace amount of the co-oligomers consisting of two TTh molecules and four or ve EDOT molecules was detected by using matrix-assisted laser desorption ionization time-ofight mass spectrometry (MALDI-TOF MS). The chemical structure of the co-oligomer was considered to be TTh bound at both ends of the EDOT tetramer or pentamer.

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Cyclodextrin-based metal-organic frameworks particles as efficient carriers for lansoprazole: Study of morphology and chemical composition of individual particles

Cited by 77 publications

References 22 publications

Recent Advances in Host–Guest Self‐Assembled Cyclodextrin Carriers: Implications for Responsive Drug Delivery and Biomedical Engineering

Recent Advances in Host–Guest Self‐Assembled Cyclodextrin Carriers: Implications for Responsive Drug Delivery and Biomedical Engineering

Improvement of the stabilities and antioxidant activities of polyphenols from the leaves of Chinese star anise (Illicium verum Hook. f.) using β‐cyclodextrin‐based metal–organic frameworks

Co-Oligomerization of Electroconductive Monomers in a Cyclodextrin-Based Metal–Organic Framework

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